The metabolic fate of [3H]estradiol in relation to dietary intake of boron in ovariectomized rats

J H  Beattie

doi:10.1016/0960-0760(93)90171-R

The metabolic fate of [³H]estradiol in relation to dietary intake of boron in ovariectomized rats

J H Beattie

The Rowett Institute of Nutrition and Health

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Abstract

It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.

Original language	English
Pages (from-to)	549-554
Number of pages	6
Journal	The Journal of Steroid Biochemistry and Molecular Biology
Volume	45
Issue number	6
DOIs	https://doi.org/10.1016/0960-0760(93)90171-R
Publication status	Published - Jun 1993

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ESTROGENS

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10.1016/0960-0760(93)90171-R

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title = "The metabolic fate of [3H]estradiol in relation to dietary intake of boron in ovariectomized rats",

abstract = "It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.",

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T1 - The metabolic fate of [3H]estradiol in relation to dietary intake of boron in ovariectomized rats

AU - Beattie, J H

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N2 - It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.

AB - It has been reported that boron (B) deprivation reversibly lowers plasma estradiol levels in postmenopausal women. In order to establish whether this reflects disturbances in the estrogen catabolic pathway and in particular in catechol estrogen metabolism, the influence of dietary B on the catabolism of [H-3]estradiol-17beta has been studied in ovariectomized rats. Rats were given diets containing < 0.1 or 40 mg B. kg-1, ovariectomized and then infused with [H-3]estradiol-17beta using osmotic pumps. Analysis of urine samples for conjugated, catechol and non-catechol estrogens did not reveal any effects of B on the recovery or the metabolic fate of tritium from the infused estradiol. These results do not therefore support the proposal that B influences estrogen catabolism by interacting with catechol estrogens.

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DO - 10.1016/0960-0760(93)90171-R

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