The multiple roles of fatty acid handling proteins in brain

Valentine S F Moullé, Céline Cansell, Serge Luquet, Céline Cruciani-Guglielmacci

Research output: Contribution to journalLiterature review

29 Citations (Scopus)

Abstract

Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellular trafficking. Here we will focus on several FA handling proteins, among which the fatty acid translocase/CD36 (FAT/CD36), members of fatty acid transport proteins (FATPs), and lipid chaperones fatty acid-binding proteins (FABPs). A decade of extensive studies has helped decipher the mechanism of action of these proteins in peripheral tissue with high lipid metabolism. However, considerably less information is available regarding their role in the brain, despite the high lipid content of this tissue. This review will primarily focus on the recent studies that have highlighted the crucial role of lipid handling proteins in brain FA transport, neuronal differentiation and development, cognitive processes and brain diseases. Finally a special focus will be made on the recent studies that have revealed the role of FAT/CD36 in brain lipid sensing and nervous control of energy balance.

Original languageEnglish
Article number385
JournalFrontiers in Physiology
Volume3
Early online date28 Sep 2012
DOIs
Publication statusPublished - 2012

Fingerprint

Fatty Acids
Lipids
Brain
Proteins
Fatty Acid Transport Proteins
Fatty Acid-Binding Proteins
Lipid Bilayers
Brain Diseases
Protein Transport
Membrane Lipids
Lipid Metabolism

Keywords

  • fatty acids
  • brain
  • FATP
  • FABP
  • CD36
  • GPR40
  • neuronal differentiation
  • cognition

Cite this

Moullé, V. S. F., Cansell, C., Luquet, S., & Cruciani-Guglielmacci, C. (2012). The multiple roles of fatty acid handling proteins in brain. Frontiers in Physiology, 3, [385]. https://doi.org/10.3389/fphys.2012.00385

The multiple roles of fatty acid handling proteins in brain. / Moullé, Valentine S F; Cansell, Céline; Luquet, Serge; Cruciani-Guglielmacci, Céline.

In: Frontiers in Physiology, Vol. 3, 385, 2012.

Research output: Contribution to journalLiterature review

Moullé, VSF, Cansell, C, Luquet, S & Cruciani-Guglielmacci, C 2012, 'The multiple roles of fatty acid handling proteins in brain', Frontiers in Physiology, vol. 3, 385. https://doi.org/10.3389/fphys.2012.00385
Moullé, Valentine S F ; Cansell, Céline ; Luquet, Serge ; Cruciani-Guglielmacci, Céline. / The multiple roles of fatty acid handling proteins in brain. In: Frontiers in Physiology. 2012 ; Vol. 3.
@article{f0f4a58f24e74204a96a1c3ba3ad41c9,
title = "The multiple roles of fatty acid handling proteins in brain",
abstract = "Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellular trafficking. Here we will focus on several FA handling proteins, among which the fatty acid translocase/CD36 (FAT/CD36), members of fatty acid transport proteins (FATPs), and lipid chaperones fatty acid-binding proteins (FABPs). A decade of extensive studies has helped decipher the mechanism of action of these proteins in peripheral tissue with high lipid metabolism. However, considerably less information is available regarding their role in the brain, despite the high lipid content of this tissue. This review will primarily focus on the recent studies that have highlighted the crucial role of lipid handling proteins in brain FA transport, neuronal differentiation and development, cognitive processes and brain diseases. Finally a special focus will be made on the recent studies that have revealed the role of FAT/CD36 in brain lipid sensing and nervous control of energy balance.",
keywords = "fatty acids, brain, FATP, FABP, CD36, GPR40, neuronal differentiation, cognition",
author = "Moull{\'e}, {Valentine S F} and C{\'e}line Cansell and Serge Luquet and C{\'e}line Cruciani-Guglielmacci",
year = "2012",
doi = "10.3389/fphys.2012.00385",
language = "English",
volume = "3",
journal = "Frontiers in Physiology",
issn = "1664-042X",
publisher = "Frontiers Media S.A.",

}

TY - JOUR

T1 - The multiple roles of fatty acid handling proteins in brain

AU - Moullé, Valentine S F

AU - Cansell, Céline

AU - Luquet, Serge

AU - Cruciani-Guglielmacci, Céline

PY - 2012

Y1 - 2012

N2 - Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellular trafficking. Here we will focus on several FA handling proteins, among which the fatty acid translocase/CD36 (FAT/CD36), members of fatty acid transport proteins (FATPs), and lipid chaperones fatty acid-binding proteins (FABPs). A decade of extensive studies has helped decipher the mechanism of action of these proteins in peripheral tissue with high lipid metabolism. However, considerably less information is available regarding their role in the brain, despite the high lipid content of this tissue. This review will primarily focus on the recent studies that have highlighted the crucial role of lipid handling proteins in brain FA transport, neuronal differentiation and development, cognitive processes and brain diseases. Finally a special focus will be made on the recent studies that have revealed the role of FAT/CD36 in brain lipid sensing and nervous control of energy balance.

AB - Lipids are essential components of a living organism as energy source but also as constituent of the membrane lipid bilayer. In addition fatty acid (FA) derivatives interact with many signaling pathways. FAs have amphipathic properties and therefore require being associated to protein for both transport and intracellular trafficking. Here we will focus on several FA handling proteins, among which the fatty acid translocase/CD36 (FAT/CD36), members of fatty acid transport proteins (FATPs), and lipid chaperones fatty acid-binding proteins (FABPs). A decade of extensive studies has helped decipher the mechanism of action of these proteins in peripheral tissue with high lipid metabolism. However, considerably less information is available regarding their role in the brain, despite the high lipid content of this tissue. This review will primarily focus on the recent studies that have highlighted the crucial role of lipid handling proteins in brain FA transport, neuronal differentiation and development, cognitive processes and brain diseases. Finally a special focus will be made on the recent studies that have revealed the role of FAT/CD36 in brain lipid sensing and nervous control of energy balance.

KW - fatty acids

KW - brain

KW - FATP

KW - FABP

KW - CD36

KW - GPR40

KW - neuronal differentiation

KW - cognition

U2 - 10.3389/fphys.2012.00385

DO - 10.3389/fphys.2012.00385

M3 - Literature review

VL - 3

JO - Frontiers in Physiology

JF - Frontiers in Physiology

SN - 1664-042X

M1 - 385

ER -