Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.
- breast cancer
- neutrophil-to-lymphocyte ratio
Faria, S. S., Fernandes, P. C., Silva, M. J. B., Lima, V. C., Fontes, W., Freitas, R., Eterovic, A. K., & Forget, P. (2016). The neutrophil-to-lymphocyte ratio: A narrative review. ecancermedicalscience, 10, . https://doi.org/10.3332/ecancer.2016.702