Abstract
| Original language | English |
|---|---|
| Article number | 702 |
| Journal | ecancermedicalscience |
| Volume | 10 |
| DOIs | |
| Publication status | Published - 12 Dec 2016 |
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Keywords
- breast cancer
- inflammation
- neutrophil-to-lymphocyte ratio
- prognosis
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The neutrophil-to-lymphocyte ratio : A narrative review. / Faria, S.S.; Fernandes, P.C.; Silva, M.J.B.; Lima, V.C.; Fontes, W.; Freitas, R.; Eterovic, A.K.; Forget, P. (Corresponding Author).
In: ecancermedicalscience, Vol. 10, 702, 12.12.2016.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The neutrophil-to-lymphocyte ratio
T2 - A narrative review
AU - Faria, S.S.
AU - Fernandes, P.C.
AU - Silva, M.J.B.
AU - Lima, V.C.
AU - Fontes, W.
AU - Freitas, R.
AU - Eterovic, A.K.
AU - Forget, P.
PY - 2016/12/12
Y1 - 2016/12/12
N2 - Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.
AB - Cellular-mediated inflammatory response, lymphocytes, neutrophils, and monocytes are increasingly being recognised as having an important role in tumorigenesis and carcinogenesis. In this context, studies have suggested that the neutrophil-to-lymphocyte ratio (NLR) can be used as an independent prognostic factor in a variety of cancers. Particularly in breast cancer, several studies have shown that a high NLR is associated with shorter survival. Because the NLR can be easily determined from the full blood count, it could potentially provide a simple and inexpensive test cancer prognosis. This review addresses the possibilities and limitations of using the NLR as a clinical tool for risk stratification helpful for individual treatment of breast cancer patients. The potential underlying phenomena and some perspectives are discussed.
KW - breast cancer
KW - inflammation
KW - neutrophil-to-lymphocyte ratio
KW - prognosis
UR - http://www.scopus.com/inward/record.url?eid=2-s2.0-85009250645&partnerID=MN8TOARS
U2 - 10.3332/ecancer.2016.702
DO - 10.3332/ecancer.2016.702
M3 - Article
VL - 10
JO - ecancermedicalscience
JF - ecancermedicalscience
M1 - 702
ER -