The Oral Tolerance as a Complex Network Phenomenon

Pedro Jeferson Miranda, Murilo Delgobo, Giovani Favero Marino, Katia Sabrina Paludo, Murilo Da Silva Baptista, Sandro Ely De Soula Pinto

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Abstract

The phenomenon of oral tolerance refers to a local and systemic state of tolerance induced in the gut after its exposure to innocuous antigens. Recent findings have shown the interrelationship between cellular and molecular components of oral tolerance, but its representation through a network of interactions has not been investigated. Our work aims at identifying the causal relationship of each element in an oral tolerance network, and also to propose a phenomenological model that’s capable of predicting the stochastic behavior of
this network when under manipulation. We compared the changes of a “healthy” network caused by “knock-outs” (KOs) in two approaches: an analytical approach by the Perron Frobenius theory; and a computational approach, which we describe within this work in order to find numerical results for the model. Both approaches have shown the most relevant immunological components for this phenomena, that happens to corroborate the empirical results from animal models. Besides explain in a intelligible fashion how the components interacts
in a complex manner, we also managed to describe and quantify the importance of KOs that hasn’t been empirically tested.
Original languageEnglish
Article number e0130762
Number of pages17
JournalPloS ONE
Volume10
Issue number6
Early online date26 Jun 2015
DOIs
Publication statusPublished - 26 Jun 2015

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Miranda, P. J., Delgobo, M., Marino, G. F., Paludo, K. S., Baptista, M. D. S., & Pinto, S. E. D. S. (2015). The Oral Tolerance as a Complex Network Phenomenon. PloS ONE, 10(6), [ e0130762]. https://doi.org/10.1371/journal.pone.0130762