The pathophysiology of diastolic heart failure

Thanh Trung Phan, Michael Frenneaux

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Whilst resting disturbances of both diastolic and long-axis systolic function are observed in patients with heart failure who have normal left ventricular ejection fraction, recent evidence suggests that dynamic disturbances in cardiac function occur during exercise. A paradoxical slowing of left ventricular active relaxation during exercise limits cardiac filling and therefore stroke volume and appears to be due to the combination of cardiac energetic impairment and disturbed ventricular-vascular coupling.
Original languageEnglish
Article number16
Number of pages4
JournalF1000 Biology Reports
Volume2
DOIs
Publication statusPublished - 24 Feb 2010

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Diastolic Heart Failure
Stroke Volume
Exercise
Blood Vessels
Heart Failure

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The pathophysiology of diastolic heart failure. / Phan, Thanh Trung; Frenneaux, Michael.

In: F1000 Biology Reports, Vol. 2, 16, 24.02.2010.

Research output: Contribution to journalArticle

Phan, Thanh Trung ; Frenneaux, Michael. / The pathophysiology of diastolic heart failure. In: F1000 Biology Reports. 2010 ; Vol. 2.
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