The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors

Joriene C de Nooij, Christian M Simon, Anna Simon, Staceyann Doobar, Karen P Steel, Robert W Banks, George Z Mentis, Guy S Bewick, Thomas M Jessell

Research output: Contribution to journalArticle

12 Citations (Scopus)
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Abstract

Mechanoreception is an essential feature of many sensory modalities. Nevertheless, the mechanisms that govern the conversion of a mechanical force to distinct patterns of action potentials remain poorly understood. Proprioceptive mechanoreceptors reside in skeletal muscle and inform the nervous system of the position of body and limbs in space. We show here that Whirlin/Deafness autosomal recessive 31 (DFNB31), a PDZ-scaffold protein involved in vestibular and auditory hair cell transduction, is also expressed by proprioceptive sensory neurons (pSNs) in dorsal root ganglia in mice. Whirlin localizes to the peripheral sensory endings of pSNs and facilitates pSN afferent firing in response to muscle stretch. The requirement of Whirlin in both proprioceptors and hair cells suggests that accessory mechanosensory signaling molecules define common features of mechanoreceptive processing across sensory systems.

Original languageEnglish
Pages (from-to)3073-3084
Number of pages12
JournalJournal of Neuroscience
Volume35
Issue number7
Early online date18 Feb 2015
DOIs
Publication statusPublished - 18 Feb 2015

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PDZ Domains
Sensory Receptor Cells
Auditory Hair Cells
Vestibular Hair Cells
Mechanoreceptors
Spinal Ganglia
Nervous System
Action Potentials
Skeletal Muscle
Proteins
Extremities
Muscles
Autosomal Recessive 31 Deafness

Keywords

  • mechanoreception
  • muscle spindle
  • PDZ proteins
  • proprioceptors
  • sensory-motor control

Cite this

de Nooij, J. C., Simon, C. M., Simon, A., Doobar, S., Steel, K. P., Banks, R. W., ... Jessell, T. M. (2015). The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors. Journal of Neuroscience, 35(7), 3073-3084. https://doi.org/10.1523/JNEUROSCI.3699-14.2015

The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors. / de Nooij, Joriene C; Simon, Christian M; Simon, Anna; Doobar, Staceyann; Steel, Karen P; Banks, Robert W; Mentis, George Z; Bewick, Guy S; Jessell, Thomas M.

In: Journal of Neuroscience, Vol. 35, No. 7, 18.02.2015, p. 3073-3084.

Research output: Contribution to journalArticle

de Nooij, JC, Simon, CM, Simon, A, Doobar, S, Steel, KP, Banks, RW, Mentis, GZ, Bewick, GS & Jessell, TM 2015, 'The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors', Journal of Neuroscience, vol. 35, no. 7, pp. 3073-3084. https://doi.org/10.1523/JNEUROSCI.3699-14.2015
de Nooij, Joriene C ; Simon, Christian M ; Simon, Anna ; Doobar, Staceyann ; Steel, Karen P ; Banks, Robert W ; Mentis, George Z ; Bewick, Guy S ; Jessell, Thomas M. / The PDZ-Domain Protein Whirlin Facilitates Mechanosensory Signaling in Mammalian Proprioceptors. In: Journal of Neuroscience. 2015 ; Vol. 35, No. 7. pp. 3073-3084.
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