The Peculiar Characteristics of Fish Type I Interferons

Pierre Boudinot, Christelle Langevin, Christopher J Secombes, Jean-Pierre Levraud

Research output: Contribution to journalArticle

16 Citations (Scopus)
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Abstract

Antiviral type I interferons (IFNs) have been discovered in fish. Genomic studies revealed their considerable number in many species; some genes encode secreted and non-secreted isoforms. Based on cysteine motifs, fish type I IFNs fall in two subgroups, which use two different receptors. Mammalian type I IFN genes are intronless while type III have introns; in fish, all have introns, but structurally, both subgroups belong to type I. Type I IFNs likely appeared early in vertebrates as intron containing genes, and evolved in parallel in tetrapods and fishes. The diversity of their repertoires in fish and mammals is likely a convergent feature, selected as a response to the variety of viral strategies. Several alternative nomenclatures have been established for different taxonomic fish groups, calling for a unified system. The specific functions of each type I gene remains poorly understood, as well as their interactions in antiviral responses. However, distinct induction pathways, kinetics of response, and tissue specificity indicate that fish type I likely are highly specialized, especially in groups where they are numerous such as salmonids or cyprinids. Unravelling their functional integration constitutes the next challenge to understand how these cytokines evolved to orchestrate antiviral innate immunity in vertebrates.

Original languageEnglish
Article number298
JournalViruses
Volume8
Issue number11
DOIs
Publication statusPublished - 2 Nov 2016

Fingerprint

Interferon Type I
Fishes
Introns
Antiviral Agents
Genes
Vertebrates
Salmonidae
Organ Specificity
Innate Immunity
Cysteine
Mammals
Protein Isoforms
Cytokines

Keywords

  • type I IFN
  • fish innate immunity
  • evolution

Cite this

The Peculiar Characteristics of Fish Type I Interferons. / Boudinot, Pierre; Langevin, Christelle; Secombes, Christopher J; Levraud, Jean-Pierre.

In: Viruses, Vol. 8, No. 11, 298, 02.11.2016.

Research output: Contribution to journalArticle

Boudinot, P, Langevin, C, Secombes, CJ & Levraud, J-P 2016, 'The Peculiar Characteristics of Fish Type I Interferons' Viruses, vol. 8, no. 11, 298. https://doi.org/10.3390/v8110298
Boudinot, Pierre ; Langevin, Christelle ; Secombes, Christopher J ; Levraud, Jean-Pierre. / The Peculiar Characteristics of Fish Type I Interferons. In: Viruses. 2016 ; Vol. 8, No. 11.
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