The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity

Kirsty Loudon (Corresponding Author), Merrick Zwarenstein, Frank Sullivan, Peter Donnan, Ildikó Gágyor, Hans Hobbelen, Fernando Althabe, Jerry A Krishnan, Shaun Treweek

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)
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Abstract

• The original PRECIS tool did not have its validity and reliability formally measured.
• The inter-rater reliability of PRECIS-2 was measured using 19 raters (trialists from seven countries) to score a varied sample of 15 RCT protocols.
• Inter-rater reliability was generally good, with seven of nine domains having an Intraclass Correlation Coefficient over 0.65.
• Each of the nine PRECIS-2 domains could be used to differentiate between trials taking more pragmatic or more explanatory approaches with better than chance discrimination for all domains.
• The validity and reliability of PRECIS-2 has been assessed.
Original languageEnglish
Pages (from-to)113-121
Number of pages9
JournalJournal of Clinical Epidemiology
Volume88
Early online date8 Jun 2017
DOIs
Publication statusPublished - Aug 2017

Keywords

  • randomized controlled trials
  • clinical trial methodology
  • validity and reliability
  • Face validity
  • trial design
  • Pragmatic clinical trial

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