Abstract
• The inter-rater reliability of PRECIS-2 was measured using 19 raters (trialists from seven countries) to score a varied sample of 15 RCT protocols.
• Inter-rater reliability was generally good, with seven of nine domains having an Intraclass Correlation Coefficient over 0.65.
• Each of the nine PRECIS-2 domains could be used to differentiate between trials taking more pragmatic or more explanatory approaches with better than chance discrimination for all domains.
• The validity and reliability of PRECIS-2 has been assessed.
| Original language | English |
|---|---|
| Pages (from-to) | 113-121 |
| Number of pages | 9 |
| Journal | Journal of Clinical Epidemiology |
| Volume | 88 |
| Early online date | 8 Jun 2017 |
| DOIs | |
| Publication status | Published - Aug 2017 |
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Keywords
- randomized controlled trials
- clinical trial methodology
- validity and reliability
- Face validity
- trial design
- Pragmatic clinical trial
Cite this
The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity. / Loudon, Kirsty (Corresponding Author); Zwarenstein, Merrick; Sullivan, Frank; Donnan, Peter; Gágyor, Ildikó ; Hobbelen, Hans ; Althabe, Fernando ; Krishnan, Jerry A; Treweek, Shaun.
In: Journal of Clinical Epidemiology, Vol. 88, 08.2017, p. 113-121.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity
AU - Loudon, Kirsty
AU - Zwarenstein, Merrick
AU - Sullivan, Frank
AU - Donnan, Peter
AU - Gágyor, Ildikó
AU - Hobbelen, Hans
AU - Althabe, Fernando
AU - Krishnan, Jerry A
AU - Treweek, Shaun
N1 - This work was supported by the Chief Scientist Office (CSO) of Scotland grant CZH/4/773, the UK Medical Research Council and the University of Dundee work through the provision of a stipend for KL and from the Health Services Research Unit at the University of Aberdeen, which is core funded by the CSO of the Scottish Government Health Directories. We are grateful to all the participants who assisted in this study: F Althabe, A-W Chan, D Altman, D Bratton, E Brass, M Campbell, G Forbes, B Gaglio, R Glasgow, H Hobbelen, S Hopewell, J Krishnan, D Riddle, J Segal, D Steinfort, P Tugwell, SN Van der Veer, VA. Welch, C Witt.
PY - 2017/8
Y1 - 2017/8
N2 - • The original PRECIS tool did not have its validity and reliability formally measured.• The inter-rater reliability of PRECIS-2 was measured using 19 raters (trialists from seven countries) to score a varied sample of 15 RCT protocols. • Inter-rater reliability was generally good, with seven of nine domains having an Intraclass Correlation Coefficient over 0.65. • Each of the nine PRECIS-2 domains could be used to differentiate between trials taking more pragmatic or more explanatory approaches with better than chance discrimination for all domains. • The validity and reliability of PRECIS-2 has been assessed.
AB - • The original PRECIS tool did not have its validity and reliability formally measured.• The inter-rater reliability of PRECIS-2 was measured using 19 raters (trialists from seven countries) to score a varied sample of 15 RCT protocols. • Inter-rater reliability was generally good, with seven of nine domains having an Intraclass Correlation Coefficient over 0.65. • Each of the nine PRECIS-2 domains could be used to differentiate between trials taking more pragmatic or more explanatory approaches with better than chance discrimination for all domains. • The validity and reliability of PRECIS-2 has been assessed.
KW - randomized controlled trials
KW - clinical trial methodology
KW - validity and reliability
KW - Face validity
KW - trial design
KW - Pragmatic clinical trial
U2 - 10.1016/j.jclinepi.2017.06.001
DO - 10.1016/j.jclinepi.2017.06.001
M3 - Article
VL - 88
SP - 113
EP - 121
JO - Journal of Clinical Epidemiology
JF - Journal of Clinical Epidemiology
SN - 0895-4356
ER -