The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity

Kirsty Loudon; Merrick Zwarenstein; Frank Sullivan; Peter Donnan; Ildikó  Gágyor; Hans  Hobbelen; Fernando  Althabe; Jerry A Krishnan; Shaun Treweek

doi:10.1016/j.jclinepi.2017.06.001

The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity

Kirsty Loudon (Corresponding Author), Merrick Zwarenstein, Frank Sullivan, Peter Donnan, Ildikó Gágyor, Hans Hobbelen, Fernando Althabe, Jerry A Krishnan, Shaun Treweek

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

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Abstract

• The original PRECIS tool did not have its validity and reliability formally measured.
• The inter-rater reliability of PRECIS-2 was measured using 19 raters (trialists from seven countries) to score a varied sample of 15 RCT protocols.
• Inter-rater reliability was generally good, with seven of nine domains having an Intraclass Correlation Coefficient over 0.65.
• Each of the nine PRECIS-2 domains could be used to differentiate between trials taking more pragmatic or more explanatory approaches with better than chance discrimination for all domains.
• The validity and reliability of PRECIS-2 has been assessed.

Original language	English
Pages (from-to)	113-121
Number of pages	9
Journal	Journal of Clinical Epidemiology
Volume	88
Early online date	8 Jun 2017
DOIs	https://doi.org/10.1016/j.jclinepi.2017.06.001
Publication status	Published - Aug 2017

Keywords

randomized controlled trials
clinical trial methodology
validity and reliability
Face validity
trial design
Pragmatic clinical trial

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© 2017. This manuscript version is made available under the CC-BY-NC-ND 4.0 license http://creativecommons.org/licenses/by-nc-nd/4.0/
Accepted author manuscript, 289 KBLicence: CC BY-NC-ND

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The PRECIS-2 tool has good inter-rater reliability and modest discriminant validity. / Loudon, Kirsty (Corresponding Author); Zwarenstein, Merrick; Sullivan, Frank; Donnan, Peter; Gágyor, Ildikó ; Hobbelen, Hans ; Althabe, Fernando ; Krishnan, Jerry A; Treweek, Shaun.

In: Journal of Clinical Epidemiology, Vol. 88, 08.2017, p. 113-121.

Research output: Contribution to journal › Article › peer-review

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abstract = "• The original PRECIS tool did not have its validity and reliability formally measured.• The inter-rater reliability of PRECIS-2 was measured using 19 raters (trialists from seven countries) to score a varied sample of 15 RCT protocols. • Inter-rater reliability was generally good, with seven of nine domains having an Intraclass Correlation Coefficient over 0.65. • Each of the nine PRECIS-2 domains could be used to differentiate between trials taking more pragmatic or more explanatory approaches with better than chance discrimination for all domains. • The validity and reliability of PRECIS-2 has been assessed.",

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