The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk

E. Troost, Georgina Louise Hold, Malcolm Gavin Smith, W. H. Chow, C. S. Rabkin, K. E. McColl, Emad Munir El-Omar

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Helicobacter pylori infects half of the world's population, and is associated with asymptomatic gastritis and also with more serious conditions such as peptic ulcer disease and gastric carcinoma. The clinical outcome is largely dependent on the severity and distribution of the H pylori-induced gastritis, but the pathogenesis remains poorly understood. Bacterial virulence factors and environmental influences contribute to the pathogenesis, but do not explain the divergent outcomes. There is emerging evidence that host genetic factors play a key role in determining the clinical outcome of H pylori infection. In particular, proinflammatory genotypes of the interleukin-1 beta (IL-1b) gene are associated with an increased risk of gastric cancer and its precursors. The effects are most likely mediated through the induction of hypochlorhydria and severe corpus gastritis with the subsequent development of gastric atrophy. The roles of IL-1b and other host genetic factors in the pathogenesis of H pylori related cancer are discussed in this article.
Original languageEnglish
Pages (from-to)8B-12B
Number of pages5
JournalCanadian Journal of Gastroenterology
Volume17
Issue numberSuppl B
Publication statusPublished - 2003

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Pylorus
Gastritis
Interleukin-1beta
Genetic Markers
Stomach Neoplasms
Achlorhydria
Stomach Diseases
Virulence Factors
Peptic Ulcer
Helicobacter pylori
Atrophy
Stomach
Genotype
Carcinoma
Infection
Population
Genes
Neoplasms

Cite this

Troost, E., Hold, G. L., Smith, M. G., Chow, W. H., Rabkin, C. S., McColl, K. E., & El-Omar, E. M. (2003). The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk. Canadian Journal of Gastroenterology, 17 (Suppl B), 8B-12B.

The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk. / Troost, E.; Hold, Georgina Louise; Smith, Malcolm Gavin; Chow, W. H.; Rabkin, C. S.; McColl, K. E.; El-Omar, Emad Munir.

In: Canadian Journal of Gastroenterology, Vol. 17 , No. Suppl B, 2003, p. 8B-12B.

Research output: Contribution to journalArticle

Troost, E, Hold, GL, Smith, MG, Chow, WH, Rabkin, CS, McColl, KE & El-Omar, EM 2003, 'The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk', Canadian Journal of Gastroenterology, vol. 17 , no. Suppl B, pp. 8B-12B.
Troost E, Hold GL, Smith MG, Chow WH, Rabkin CS, McColl KE et al. The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk. Canadian Journal of Gastroenterology. 2003;17 (Suppl B):8B-12B.
Troost, E. ; Hold, Georgina Louise ; Smith, Malcolm Gavin ; Chow, W. H. ; Rabkin, C. S. ; McColl, K. E. ; El-Omar, Emad Munir. / The role of interleukin-1beta and other potential genetic markers as indicators of gastric cancer risk. In: Canadian Journal of Gastroenterology. 2003 ; Vol. 17 , No. Suppl B. pp. 8B-12B.
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