The role of intrauterine insemination in male infertility

Hammed Akanji Tijani, Siladitya Bhattacharya

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Male infertility is a common condition and intrauterine insemination (IUI) is used to treat the mild to moderate forms. Male subfertility determination is usually based on routine semen analysis but recent publications have questioned its diagnostic and prognostic accuracy as well as the effectiveness of IUI itself, as a treatment modality. We carried out a structured review of the literature to assess the current evidence regarding the diagnosis of male infertility, the effectiveness and cost effectiveness of IUI in male infertility and factors that affect the outcome of IUI. There is still uncertainty regarding the criteria for diagnosing male infertility and predicting treatment outcome based on standard semen parameters. The presence of seminal defects compromises the outcome of IUI in comparison with unexplained infertility. The total motile sperm count (TMSC) appears to have a consistent, direct relationship with treatment outcome, but there is no definite predictive threshold for success. However, it is reasonable to offer IUI as first-line treatment if TMSC is greater than 10 million when balancing the risk and cost of alternate treatments, such as in vitro fertilization (IVF). Sperm DNA studies and sperm preparation techniques warrant further studies in order to establish their clinical relevance. There are limited data on the clinical and cost-effectiveness of IUI in male infertility and large high-quality randomized controlled trials are warranted. However the difficulties in organizing such a study, at the present time, are a matter for discussion.
Original languageEnglish
Pages (from-to)226-232
Number of pages7
JournalHuman Fertility
Volume13
Issue number4
DOIs
Publication statusPublished - 1 Dec 2010

Fingerprint

Insemination
Male Infertility
Sperm Count
Cost-Benefit Analysis
Spermatozoa
Semen Analysis
Fertilization in Vitro
Semen
Health Care Costs
Infertility
Uncertainty
Randomized Controlled Trials
DNA
Therapeutics

Keywords

  • intrauterine insemination
  • male factor infertility
  • ovarian stimulation

Cite this

The role of intrauterine insemination in male infertility. / Akanji Tijani, Hammed; Bhattacharya, Siladitya.

In: Human Fertility, Vol. 13, No. 4, 01.12.2010, p. 226-232.

Research output: Contribution to journalArticle

Akanji Tijani, Hammed ; Bhattacharya, Siladitya. / The role of intrauterine insemination in male infertility. In: Human Fertility. 2010 ; Vol. 13, No. 4. pp. 226-232.
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