The Role of Vitamin D in Disease Progression in Early Parkinson's Disease

Isobel Sleeman* (Corresponding Author), Terry Aspray, Rachael Lawson, Shirley Coleman, Gordon Duncan, Tien K Khoo, Inez Schoenmakers, Lynn Rochester, David Burn, Alison Yarnall

*Corresponding author for this work

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Previous cross-sectional studies have shown that Parkinson's disease (PD) patients have lower serum 25-hydroxy vitamin D (25(OH)D) concentrations than controls. Vitamin D deficiency was associated with increased disease severity and cognitive impairment in prevalent PD patients.

OBJECTIVE: The aim of the study was to determine 25(OH)D in newly diagnosed PD and age-matched controls and to assess if there was an association with clinical outcomes (disease severity, cognition and falls) over the 36-month follow up period.

METHODS: A prospective observational study of newly diagnosed PD patients in the North East of England with age-matched controls (PD, n = 145; control, n = 94). Serum 25(OH)D was assessed at baseline and 18 months. Participants underwent clinical assessment at baseline, 18 and 36 months. One hundred and ten participants with PD also took part in a prospective falls study.

RESULTS: Mean serum 25(OH)D concentrations were lower in PD than control participants at baseline (44.1±21.7 vs. 52.2±22.1 nmol/L, p < 0.05) and 18 months (44.2±23.6 vs. 55.7±28.8 nmol/L, p < 0.05). Baseline serum 25(OH)D concentration, age, motor score and dosage of dopaminergic medication were significant predictors of variance of motor severity at 36 months ((ΔR2 = 0.039, F = 6.6, p < 0.01). Serum 25(OH)D was not associated with cognition or falls during the follow up period.

CONCLUSIONS: Patients with incident PD had significantly lower serum 25(OH)D concentrations than age-matched controls, which may have implications in terms of bone health and fracture risk. There was a small but significant association between vitamin D status at baseline and disease motor severity at 36 months.

Original languageEnglish
Pages (from-to)669-675
Number of pages7
Journal Journal of Parkinson's Disease
Volume7
Issue number4
DOIs
Publication statusPublished - 1 Nov 2017

Keywords

  • balance
  • cognition
  • disease progression
  • fall
  • 25-hydroxy vitamin D
  • Parkinson's disease
  • vitamin D

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  • Cite this

    Sleeman, I., Aspray, T., Lawson, R., Coleman, S., Duncan, G., Khoo, T. K., Schoenmakers, I., Rochester, L., Burn, D., & Yarnall, A. (2017). The Role of Vitamin D in Disease Progression in Early Parkinson's Disease. Journal of Parkinson's Disease, 7(4), 669-675. https://doi.org/10.3233/JPD-171122