The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort

Maryam Alidoust, Asma Khorshid Shamshiri, Amir Tajbakhsh, Seyed Mohammad Gheibihayat, Seyed Mostafa Mazloom, Farzaneh Alizadeh, Alireza Pasdar*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.

Original languageEnglish
Pages (from-to)4895-4905
Number of pages11
JournalFuture Oncology
Volume17
Issue number35
Early online date3 Nov 2021
DOIs
Publication statusPublished - Dec 2021

Keywords

  • association study
  • breast carcinoma
  • NF-κB
  • risk factor
  • rs28362491
  • variation

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