Abstract
Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.
Original language | English |
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Pages (from-to) | 4895-4905 |
Number of pages | 11 |
Journal | Future Oncology |
Volume | 17 |
Issue number | 35 |
Early online date | 3 Nov 2021 |
DOIs | |
Publication status | Published - Dec 2021 |
Keywords
- association study
- breast carcinoma
- NF-κB
- risk factor
- rs28362491
- variation