The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort

Maryam Alidoust; Asma Khorshid Shamshiri; Amir Tajbakhsh; Seyed Mohammad Gheibihayat; Seyed Mostafa Mazloom; Farzaneh Alizadeh; Alireza Pasdar

doi:10.2217/fon-2021-0197

The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort

Maryam Alidoust, Asma Khorshid Shamshiri, Amir Tajbakhsh, Seyed Mohammad Gheibihayat, Seyed Mostafa Mazloom, Farzaneh Alizadeh, Alireza Pasdar^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.

Original language	English
Pages (from-to)	4895-4905
Number of pages	11
Journal	Future Oncology
Volume	17
Issue number	35
Early online date	3 Nov 2021
DOIs	https://doi.org/10.2217/fon-2021-0197
Publication status	Published - Dec 2021

Keywords

association study
breast carcinoma
NF-κB
risk factor
rs28362491
variation

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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@article{5d6e33de6447418f9555d46532118907,

title = "The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort",

abstract = "Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population. ",

keywords = "association study, breast carcinoma, NF-κB, risk factor, rs28362491, variation",

author = "Maryam Alidoust and Shamshiri, {Asma Khorshid} and Amir Tajbakhsh and Gheibihayat, {Seyed Mohammad} and Mazloom, {Seyed Mostafa} and Farzaneh Alizadeh and Alireza Pasdar",

note = "Funding Information: This research was supported by the Student Research Committee affiliated with Mashhad University of Medical Sciences, Iran (grant no: 961689). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript. ",

year = "2021",

month = dec,

doi = "10.2217/fon-2021-0197",

language = "English",

volume = "17",

pages = "4895--4905",

journal = "Future Oncology",

issn = "1479-6694",

publisher = "Future Medicine Ltd.",

number = "35",

}

TY - JOUR

T1 - The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer

T2 - evidence from an Iranian cohort

AU - Alidoust, Maryam

AU - Shamshiri, Asma Khorshid

AU - Tajbakhsh, Amir

AU - Gheibihayat, Seyed Mohammad

AU - Mazloom, Seyed Mostafa

AU - Alizadeh, Farzaneh

AU - Pasdar, Alireza

N1 - Funding Information: This research was supported by the Student Research Committee affiliated with Mashhad University of Medical Sciences, Iran (grant no: 961689). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. No writing assistance was utilized in the production of this manuscript.

PY - 2021/12

Y1 - 2021/12

N2 - Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.

AB - Aims: Breast cancer (BC) is one of the most common cancers among women. The influence of genetic variations on BC risk has been thus far assessed via genome-wide association studies. NF-κB has been recognized as a major player in BC progression. In this study, the association between rs28362491 and BC was evaluated in a population from northeastern Iran. Materials & methods: This study was conducted on 476 patients with BC and 524 healthy controls. The genotyping method used was an amplification-refractory mutation system. Results: The INS/DEL genotype conferred a statistically significant increased risk in patients in comparison with controls. Additionally, in the recessive model, INS/INS + INS/DEL versus DEL/DEL was statistically significant (OR = 0.34; 95% CI: 0.12-0.96; p = 0.042). Conclusion: This study found that rs28362491, as a susceptibility genetic factor, may affect BC risk in the Iranian population.

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KW - breast carcinoma

KW - NF-κB

KW - risk factor

KW - rs28362491

KW - variation

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The significant role of a functional polymorphism in the NF-κB1 gene in breast cancer: evidence from an Iranian cohort

Abstract

Keywords

UN SDGs

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