The suitability of gamma camera coincidence systems for nitrogen 13-labeled ammonia myocardial perfusion imaging: a quantitative comparison with full-ring PET

F. I. McKiddie, Howard .g. Gemmell, Andrew Welch, E. J. Davidson, M. Egred

Research output: Contribution to journalArticle

Abstract

Background. The aim of this study was to examine the quality of nitrogen 13-labeled ammonia (NH3) perfusion data from coincidence-capable gamma camera positron emission tomography (GC-PET) systems compared with that from full-ring positron emission tomography (FR-PET). Methods and Results. The performance parameters of the GC-PET system were examined and found adequate for imaging at the activity levels used clinically. We studied 15 patients who underwent stress and rest N-13-labeled NH3 perfusion imaging on FR-PET and GC-PET systems. Quantitative analysis of perfusion values showed that GC-PET uptake was significantly lower than FR-PET uptake in 67.6% of segments. Bland-Altman analysis showed that the mean difference between FR-PET and GC-PET values was from 5.3% to 5.9%. Stress FR-PET identified 49 segments as having impaired perfusion, 46 (93.9%) of which were also identified by GC-PET. Fifty-six additional segments were identified as abnormal by GC-PET. These findings indicated a general overestimation of defect size on GC-PET. Analysis of the degree of perfusion reduction also found that GC-PET tended to overestimate defect contrast. These findings are similar to those previously found by workers examining fluorine 18-fluorodeoxyglucose uptake by both techniques. Conclusions. Good concordance was shown between GC-PET and FR-PET systems for N-13-labeled NH3 perfusion imaging, although further work is required to optimize the technique.

Original languageEnglish
Pages (from-to)633-643
Number of pages10
JournalJournal of Nuclear Cardiology
Volume10
Issue number6
DOIs
Publication statusPublished - 2003

Keywords

  • gamma camera coincidence imaging
  • positron emission tomography
  • nitrogen 13-labeled ammonia
  • myocardial perfusion
  • myocardial viability
  • POSITRON-EMISSION-TOMOGRAPHY
  • CORONARY-ARTERY DISEASE
  • LEFT-VENTRICULAR DYSFUNCTION
  • ATTENUATION CORRECTION
  • N-13 AMMONIA
  • SPECT
  • VIABILITY
  • FLUORODEOXYGLUCOSE
  • FLUORINE-18-FDG
  • PERFORMANCE

Cite this

@article{6122aa7a3fbf452b907358ca7a6e0a91,
title = "The suitability of gamma camera coincidence systems for nitrogen 13-labeled ammonia myocardial perfusion imaging: a quantitative comparison with full-ring PET",
abstract = "Background. The aim of this study was to examine the quality of nitrogen 13-labeled ammonia (NH3) perfusion data from coincidence-capable gamma camera positron emission tomography (GC-PET) systems compared with that from full-ring positron emission tomography (FR-PET). Methods and Results. The performance parameters of the GC-PET system were examined and found adequate for imaging at the activity levels used clinically. We studied 15 patients who underwent stress and rest N-13-labeled NH3 perfusion imaging on FR-PET and GC-PET systems. Quantitative analysis of perfusion values showed that GC-PET uptake was significantly lower than FR-PET uptake in 67.6{\%} of segments. Bland-Altman analysis showed that the mean difference between FR-PET and GC-PET values was from 5.3{\%} to 5.9{\%}. Stress FR-PET identified 49 segments as having impaired perfusion, 46 (93.9{\%}) of which were also identified by GC-PET. Fifty-six additional segments were identified as abnormal by GC-PET. These findings indicated a general overestimation of defect size on GC-PET. Analysis of the degree of perfusion reduction also found that GC-PET tended to overestimate defect contrast. These findings are similar to those previously found by workers examining fluorine 18-fluorodeoxyglucose uptake by both techniques. Conclusions. Good concordance was shown between GC-PET and FR-PET systems for N-13-labeled NH3 perfusion imaging, although further work is required to optimize the technique.",
keywords = "gamma camera coincidence imaging, positron emission tomography, nitrogen 13-labeled ammonia, myocardial perfusion, myocardial viability, POSITRON-EMISSION-TOMOGRAPHY, CORONARY-ARTERY DISEASE, LEFT-VENTRICULAR DYSFUNCTION, ATTENUATION CORRECTION, N-13 AMMONIA, SPECT, VIABILITY, FLUORODEOXYGLUCOSE, FLUORINE-18-FDG, PERFORMANCE",
author = "McKiddie, {F. I.} and Gemmell, {Howard .g.} and Andrew Welch and Davidson, {E. J.} and M. Egred",
year = "2003",
doi = "10.1016/S1071-3581(03)00658-5",
language = "English",
volume = "10",
pages = "633--643",
journal = "Journal of Nuclear Cardiology",
issn = "1071-3581",
publisher = "Springer New York",
number = "6",

}

TY - JOUR

T1 - The suitability of gamma camera coincidence systems for nitrogen 13-labeled ammonia myocardial perfusion imaging: a quantitative comparison with full-ring PET

AU - McKiddie, F. I.

AU - Gemmell, Howard .g.

AU - Welch, Andrew

AU - Davidson, E. J.

AU - Egred, M.

PY - 2003

Y1 - 2003

N2 - Background. The aim of this study was to examine the quality of nitrogen 13-labeled ammonia (NH3) perfusion data from coincidence-capable gamma camera positron emission tomography (GC-PET) systems compared with that from full-ring positron emission tomography (FR-PET). Methods and Results. The performance parameters of the GC-PET system were examined and found adequate for imaging at the activity levels used clinically. We studied 15 patients who underwent stress and rest N-13-labeled NH3 perfusion imaging on FR-PET and GC-PET systems. Quantitative analysis of perfusion values showed that GC-PET uptake was significantly lower than FR-PET uptake in 67.6% of segments. Bland-Altman analysis showed that the mean difference between FR-PET and GC-PET values was from 5.3% to 5.9%. Stress FR-PET identified 49 segments as having impaired perfusion, 46 (93.9%) of which were also identified by GC-PET. Fifty-six additional segments were identified as abnormal by GC-PET. These findings indicated a general overestimation of defect size on GC-PET. Analysis of the degree of perfusion reduction also found that GC-PET tended to overestimate defect contrast. These findings are similar to those previously found by workers examining fluorine 18-fluorodeoxyglucose uptake by both techniques. Conclusions. Good concordance was shown between GC-PET and FR-PET systems for N-13-labeled NH3 perfusion imaging, although further work is required to optimize the technique.

AB - Background. The aim of this study was to examine the quality of nitrogen 13-labeled ammonia (NH3) perfusion data from coincidence-capable gamma camera positron emission tomography (GC-PET) systems compared with that from full-ring positron emission tomography (FR-PET). Methods and Results. The performance parameters of the GC-PET system were examined and found adequate for imaging at the activity levels used clinically. We studied 15 patients who underwent stress and rest N-13-labeled NH3 perfusion imaging on FR-PET and GC-PET systems. Quantitative analysis of perfusion values showed that GC-PET uptake was significantly lower than FR-PET uptake in 67.6% of segments. Bland-Altman analysis showed that the mean difference between FR-PET and GC-PET values was from 5.3% to 5.9%. Stress FR-PET identified 49 segments as having impaired perfusion, 46 (93.9%) of which were also identified by GC-PET. Fifty-six additional segments were identified as abnormal by GC-PET. These findings indicated a general overestimation of defect size on GC-PET. Analysis of the degree of perfusion reduction also found that GC-PET tended to overestimate defect contrast. These findings are similar to those previously found by workers examining fluorine 18-fluorodeoxyglucose uptake by both techniques. Conclusions. Good concordance was shown between GC-PET and FR-PET systems for N-13-labeled NH3 perfusion imaging, although further work is required to optimize the technique.

KW - gamma camera coincidence imaging

KW - positron emission tomography

KW - nitrogen 13-labeled ammonia

KW - myocardial perfusion

KW - myocardial viability

KW - POSITRON-EMISSION-TOMOGRAPHY

KW - CORONARY-ARTERY DISEASE

KW - LEFT-VENTRICULAR DYSFUNCTION

KW - ATTENUATION CORRECTION

KW - N-13 AMMONIA

KW - SPECT

KW - VIABILITY

KW - FLUORODEOXYGLUCOSE

KW - FLUORINE-18-FDG

KW - PERFORMANCE

U2 - 10.1016/S1071-3581(03)00658-5

DO - 10.1016/S1071-3581(03)00658-5

M3 - Article

VL - 10

SP - 633

EP - 643

JO - Journal of Nuclear Cardiology

JF - Journal of Nuclear Cardiology

SN - 1071-3581

IS - 6

ER -