Abstract
Toxic epidermal necrolysis (TEN) is a severe life-threatening disorder which has many features in common with graft-versus-host disease. However, immunosuppression with steroids gives disappointing results and is possibly detrimental. We treated two patients who had TEN with a combination of cyclosporin and steroids which resulted in an apparent halt to the evolution of the disease, and a further relapse was aborted using cyclosporin in one of these patients. We feel that the use of this drug in the early treatment of TEN where it is used as a specific therapy aimed at the primary immunopathological events and is used in conjunction with the supportive care patients require, needs to be further evaluated.
Original language | English |
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Pages (from-to) | 264-265 |
Number of pages | 2 |
Journal | Clinical and Experimental Dermatology |
Volume | 17 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jul 1992 |
Keywords
- Adult
- Cyclosporine
- Drug Therapy, Combination
- Epidermal Necrolysis, Toxic
- Female
- Humans
- Liver
- Prednisolone