Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans

Julia Bornhorst, Franziska Ebert, Sören Meyer, Vanessa Ziemann, Chan Xiong, Nikolaus Guttenberger, Andrea Raab, Jessica Baesler, Michael Aschner, Jörg Feldmann, Kevin Francesconi, Georg Raber, Tanja Schwerdtle* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

Although fish and seafood are well known for their nutritional benefits, they contain contaminants that might affect human health. Organic lipid-soluble arsenic species, so called arsenolipids, belong to the emerging contaminants in these food items; their toxicity has yet to be systematically studied. Here, we apply the in vivo model Caenorhabditis elegans to assess the effects of two arsenic-containing hydrocarbons (AsHC), a saturated arsenic-containing fatty acid (AsFA), and an arsenic-containing triacylglyceride (AsTAG) in a whole organism. Although all arsenolipids were highly bioavailable in Caenorhabditis elegans, only the AsHCs were substantially metabolized to thioxylated or shortened metabolic products and induced significant toxicity, affecting both survival and development. Furthermore, the AsHCs were several fold more potent as compared to the toxic reference arsenite. This study clearly indicates the need for a full hazard identification of subclasses of arsenolipids to assess whether they pose a risk to human health.

Original languageEnglish
Pages (from-to)794-798
Number of pages5
JournalMetallomics
Volume12
Issue number5
Early online date23 Mar 2020
DOIs
Publication statusPublished - 27 May 2020

Keywords

  • ARSENIC-CONTAINING HYDROCARBONS
  • VITRO TOXICOLOGICAL CHARACTERIZATION
  • CONTAINING FATTY-ACIDS
  • MODEL
  • FISH
  • METABOLISM
  • BRAIN
  • OIL

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    Bornhorst, J., Ebert, F., Meyer, S., Ziemann, V., Xiong, C., Guttenberger, N., Raab, A., Baesler, J., Aschner, M., Feldmann, J., Francesconi, K., Raber, G., & Schwerdtle, T. (2020). Toxicity of three types of arsenolipids: species-specific effects in Caenorhabditis elegans. Metallomics, 12(5), 794-798. https://doi.org/10.1039/d0mt00039f