Utilisation of prophylactic mastectomy in 10 European centers

D G R Evans, E Anderson, F Lalloo, H Vasen, M Beckmann, D Eccles, S Hodgson, P Moller, J Chang-Claude, P Morrison, D Stoppa-Lyonnet, M Steel, N Haites

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol including at least two risk counselling sessions and a psychological assessment. Thus far the combined centres have data on 174 women who have undergone prophylactic mastectomy with in excess of 400 women years of follow up. Operations were carried out on women with lifetime risks of 25-80%, with an average annual expected incidence rate of 1% per women. No breast cancers have occurred in this cohort. Long term follow up on an extended group of women will be necessary to truly address the risk of subsequent breast cancer and the psychological sequelae.

Original languageEnglish
Pages (from-to)148-151
Number of pages4
JournalDisease Markers
Volume15
Publication statusPublished - 1999

Keywords

  • BREAST-CANCER
  • BRCA1
  • CARRIERS
  • GENE

Cite this

Evans, D. G. R., Anderson, E., Lalloo, F., Vasen, H., Beckmann, M., Eccles, D., ... Haites, N. (1999). Utilisation of prophylactic mastectomy in 10 European centers. Disease Markers, 15, 148-151.

Utilisation of prophylactic mastectomy in 10 European centers. / Evans, D G R ; Anderson, E ; Lalloo, F ; Vasen, H ; Beckmann, M ; Eccles, D ; Hodgson, S ; Moller, P ; Chang-Claude, J ; Morrison, P ; Stoppa-Lyonnet, D ; Steel, M ; Haites, N .

In: Disease Markers, Vol. 15, 1999, p. 148-151.

Research output: Contribution to journalArticle

Evans, DGR, Anderson, E, Lalloo, F, Vasen, H, Beckmann, M, Eccles, D, Hodgson, S, Moller, P, Chang-Claude, J, Morrison, P, Stoppa-Lyonnet, D, Steel, M & Haites, N 1999, 'Utilisation of prophylactic mastectomy in 10 European centers', Disease Markers, vol. 15, pp. 148-151.
Evans DGR, Anderson E, Lalloo F, Vasen H, Beckmann M, Eccles D et al. Utilisation of prophylactic mastectomy in 10 European centers. Disease Markers. 1999;15:148-151.
Evans, D G R ; Anderson, E ; Lalloo, F ; Vasen, H ; Beckmann, M ; Eccles, D ; Hodgson, S ; Moller, P ; Chang-Claude, J ; Morrison, P ; Stoppa-Lyonnet, D ; Steel, M ; Haites, N . / Utilisation of prophylactic mastectomy in 10 European centers. In: Disease Markers. 1999 ; Vol. 15. pp. 148-151.
@article{c3c1042bc8fb4cc6959b6aa48333cff7,
title = "Utilisation of prophylactic mastectomy in 10 European centers",
abstract = "Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol including at least two risk counselling sessions and a psychological assessment. Thus far the combined centres have data on 174 women who have undergone prophylactic mastectomy with in excess of 400 women years of follow up. Operations were carried out on women with lifetime risks of 25-80{\%}, with an average annual expected incidence rate of 1{\%} per women. No breast cancers have occurred in this cohort. Long term follow up on an extended group of women will be necessary to truly address the risk of subsequent breast cancer and the psychological sequelae.",
keywords = "BREAST-CANCER, BRCA1, CARRIERS, GENE",
author = "Evans, {D G R} and E Anderson and F Lalloo and H Vasen and M Beckmann and D Eccles and S Hodgson and P Moller and J Chang-Claude and P Morrison and D Stoppa-Lyonnet and M Steel and N Haites",
year = "1999",
language = "English",
volume = "15",
pages = "148--151",
journal = "Disease Markers",
issn = "0278-0240",
publisher = "IOS Press",

}

TY - JOUR

T1 - Utilisation of prophylactic mastectomy in 10 European centers

AU - Evans, D G R

AU - Anderson, E

AU - Lalloo, F

AU - Vasen, H

AU - Beckmann, M

AU - Eccles, D

AU - Hodgson, S

AU - Moller, P

AU - Chang-Claude, J

AU - Morrison, P

AU - Stoppa-Lyonnet, D

AU - Steel, M

AU - Haites, N

PY - 1999

Y1 - 1999

N2 - Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol including at least two risk counselling sessions and a psychological assessment. Thus far the combined centres have data on 174 women who have undergone prophylactic mastectomy with in excess of 400 women years of follow up. Operations were carried out on women with lifetime risks of 25-80%, with an average annual expected incidence rate of 1% per women. No breast cancers have occurred in this cohort. Long term follow up on an extended group of women will be necessary to truly address the risk of subsequent breast cancer and the psychological sequelae.

AB - Increasingly women at high risk of breast cancer are opting for prophylactic surgery to reduce their risks. Data from 10 European centres that offer a risk counselling and screening service to women at risk show different approaches to the option of preventive surgery, although most centres adhere to a protocol including at least two risk counselling sessions and a psychological assessment. Thus far the combined centres have data on 174 women who have undergone prophylactic mastectomy with in excess of 400 women years of follow up. Operations were carried out on women with lifetime risks of 25-80%, with an average annual expected incidence rate of 1% per women. No breast cancers have occurred in this cohort. Long term follow up on an extended group of women will be necessary to truly address the risk of subsequent breast cancer and the psychological sequelae.

KW - BREAST-CANCER

KW - BRCA1

KW - CARRIERS

KW - GENE

M3 - Article

VL - 15

SP - 148

EP - 151

JO - Disease Markers

JF - Disease Markers

SN - 0278-0240

ER -