Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project

Amanda E.  Nelson; Yvonne M.  Golightly; Jordan B.  Renner; Todd A. Schwartz; Felix Liu; John A. Lynch; Jenny S. Gregory; Richard M. Aspden; Nancy E. Lane; Joanne M.  Jordan

doi:10.3899/jrheum.150559

Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project

Amanda E. Nelson, Yvonne M. Golightly, Jordan B. Renner, Todd A. Schwartz, Felix Liu, John A. Lynch, Jenny S. Gregory, Richard M. Aspden, Nancy E. Lane, Joanne M. Jordan

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Abstract

Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints.

Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ≥ 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ≥ 2), and progressive knee rOA (KL increase of ≥ 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations.

Results. We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA.

Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA.

Original language	English
Pages (from-to)	405-410
Number of pages	6
Journal	Journal of Rheumatology
Volume	43
Issue number	2
Early online date	15 Dec 2015
DOIs	https://doi.org/10.3899/jrheum.150559
Publication status	Published - 1 Feb 2016

Bibliographical note

Acknowledgment

We thank our funding sources, as well as the staff and participants in the Johnston County Osteoarthritis Project, without whom this work would not be possible.

Funding was provided in part by the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K23 AR061406 (Nelson); US National Institutes of Health (NIH)/NIAMS P60AR30701 (Jordan/Renner/Schwartz); US Centers for Disease Control/Association of Schools of Public Health S043 and S3486 (Jordan/Renner); K24-AR04884, P50-AR063043, and P50-AR060752 (Lane); and NIH/National Center for Advancing Translational Sciences KL2TR001109 (Golightly).

Keywords

hip joint
knee osteoarthritis
radiography

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Accepted Manuscript
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in The Journal of Rheumatology following peer review. The definitive publisher-authenticated version Nelson, AE, Golightly, YM, Renner, JB, Schwartz, TA, Liu, F, Lynch, JA, Gregory, JS, Aspden, RM, Lane, NE & Jordan, JM 2016, 'Variations in hip shape are associated with radiographic knee osteoarthritis: cross-sectional and longitudinal analyses of the Johnston County Osteoarthritis Project' Journal of Rheumatology, vol 43, no. 2, pp. 405-410., 10.3899/jrheum.150559is available online at: http://www.jrheum.org/content/43/2/405
Accepted author manuscript, 162 KBLicence: Unspecified

Jenny Gregory
Person: Academic Related - Scholarship

Cite this

Nelson, A. E., Golightly, Y. M., Renner, J. B., Schwartz, T. A., Liu, F., Lynch, J. A., Gregory, J. S., Aspden, R. M., Lane, N. E., & Jordan, J. M. (2016). Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project. Journal of Rheumatology, 43(2), 405-410. https://doi.org/10.3899/jrheum.150559

Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project. / Nelson, Amanda E. ; Golightly, Yvonne M. ; Renner, Jordan B. et al.
In: Journal of Rheumatology, Vol. 43, No. 2, 01.02.2016, p. 405-410.

Research output: Contribution to journal › Article › peer-review

Nelson, AE, Golightly, YM, Renner, JB, Schwartz, TA, Liu, F, Lynch, JA, Gregory, JS , Aspden, RM, Lane, NE & Jordan, JM 2016, 'Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project', Journal of Rheumatology, vol. 43, no. 2, pp. 405-410. https://doi.org/10.3899/jrheum.150559

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title = "Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project",

abstract = "Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints.Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ≥ 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ≥ 2), and progressive knee rOA (KL increase of ≥ 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations.Results. We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA.Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA.",

keywords = "hip joint, knee osteoarthritis, radiography",

author = "Nelson, {Amanda E.} and Golightly, {Yvonne M.} and Renner, {Jordan B.} and Schwartz, {Todd A.} and Felix Liu and Lynch, {John A.} and Gregory, {Jenny S.} and Aspden, {Richard M.} and Lane, {Nancy E.} and Jordan, {Joanne M.}",

note = "Acknowledgment We thank our funding sources, as well as the staff and participants in the Johnston County Osteoarthritis Project, without whom this work would not be possible. Funding was provided in part by the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K23 AR061406 (Nelson); US National Institutes of Health (NIH)/NIAMS P60AR30701 (Jordan/Renner/Schwartz); US Centers for Disease Control/Association of Schools of Public Health S043 and S3486 (Jordan/Renner); K24-AR04884, P50-AR063043, and P50-AR060752 (Lane); and NIH/National Center for Advancing Translational Sciences KL2TR001109 (Golightly).",

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T1 - Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis

T2 - Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project

AU - Nelson, Amanda E.

AU - Golightly, Yvonne M.

AU - Renner, Jordan B.

AU - Schwartz, Todd A.

AU - Liu, Felix

AU - Lynch, John A.

AU - Gregory, Jenny S.

AU - Aspden, Richard M.

AU - Lane, Nancy E.

AU - Jordan, Joanne M.

N1 - Acknowledgment We thank our funding sources, as well as the staff and participants in the Johnston County Osteoarthritis Project, without whom this work would not be possible. Funding was provided in part by the US National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) K23 AR061406 (Nelson); US National Institutes of Health (NIH)/NIAMS P60AR30701 (Jordan/Renner/Schwartz); US Centers for Disease Control/Association of Schools of Public Health S043 and S3486 (Jordan/Renner); K24-AR04884, P50-AR063043, and P50-AR060752 (Lane); and NIH/National Center for Advancing Translational Sciences KL2TR001109 (Golightly).

PY - 2016/2/1

Y1 - 2016/2/1

N2 - Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints.Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ≥ 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ≥ 2), and progressive knee rOA (KL increase of ≥ 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations.Results. We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA.Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA.

AB - Objective. Hip shape by statistical shape modeling (SSM) is associated with hip radiographic osteoarthritis (rOA). We examined associations between hip shape and knee rOA given the biomechanical interrelationships between these joints.Methods. Bilateral baseline hip shape assessments [for those with at least 1 hip with a Kellgren-Lawrence arthritis grading scale (KL) 0 or 1] from the Johnston County Osteoarthritis Project were available. Proximal femur shape was defined on baseline pelvis radiographs and evaluated by SSM, producing mean shape and continuous variables representing independent modes of variation (14 modes = 95% of shape variance). Outcomes included prevalent [baseline KL ≥ 2 or total knee replacement (TKR)], incident (baseline KL 0/1 with followup ≥ 2), and progressive knee rOA (KL increase of ≥ 1 or TKR). Limb-based logistic regression models for ipsilateral and contralateral comparisons were adjusted for age, sex, race, body mass index (BMI), and hip rOA, accounting for intraperson correlations.Results. We evaluated 681 hips and 682 knees from 342 individuals (61% women, 83% white, mean age 62 yrs, BMI 29 kg/m2). Ninety-nine knees (15%) had prevalent rOA (4 knees with TKR). Lower modes 2 and 3 scores were associated with ipsilateral prevalent knee rOA, and only lower mode 3 scores were associated with contralateral prevalent knee rOA. No statistically significant associations were seen for incident or progressive knee rOA.Conclusion. Variations in hip shape were associated with prevalent, but not incident or progressive, knee rOA in this cohort, and may reflect biomechanical differences between limbs, genetic influences, or common factors related to both hip shape and knee rOA.

KW - hip joint

KW - knee osteoarthritis

KW - radiography

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DO - 10.3899/jrheum.150559

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SN - 0315-162X

VL - 43

SP - 405

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JO - Journal of Rheumatology

JF - Journal of Rheumatology

IS - 2

ER -

Variations in Hip Shape Are Associated with Radiographic Knee Osteoarthritis: Cross-sectional and Longitudinal Analyses of the Johnston County Osteoarthritis Project

Abstract

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