Abstract
Twenty male smokers and 20 non-smokers took either vitamin E capsules (1000 IU/day) or placebo for 14 days. Erythrocytes from smokers showed a marked tendency to peroxidise in vitro compared with non-smokers, an effect which was abolished by vitamin E supplementation. The increased erythrocyte peroxidation may reflect a lipid hydroperoxide-induced decrease in glucose-6-phosphate dehydrogenase activity. Evidence that smokers incurred a sustained oxidant stress also included increased plasma conjugated dienes, decreased plasma vitamin C and an increase in erythrocyte glutathione. Plasma cholesterol, vitamin E and conjugated dienes increased with age in all groups. Results suggest that smokers are under a sustained oxidant stress, some indices of which can be partially ameliored by vitamin E supplementation.
Original language | English |
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Pages (from-to) | 456-458 |
Number of pages | 3 |
Journal | Lipid / Fett |
Volume | 92 |
Issue number | 11 |
DOIs | |
Publication status | Published - Nov 1990 |
Keywords
- lipid-peroxidation
- erythrocytes
- acid
- exercise