Wainunuamide, a histidine-containing proline-rich cyclic heptapeptide isolated from the Fijian marine sponge Stylotella aurantium

Jioji Natadra Tabudravu, L. A. Morris, J. J. Kettenes-van den Bosch, Marcel Jaspars

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Abstract

The isolation and Structure determination of an unusual cyclic heptapeptide. wainunuamide, from a Fijian marine sponge, Stylotella aurantium, is reported. The peptide contains three proline residues and a histidine residue, which is rare in cyclic peptides and has only Previously been reported in a cyclic peptide isolated from the cyanobacterium Oscillatoria agardhii, suggesting a possible source of the peptide. Wainunuamide is found to have weak cytotoxic activity. (C) 2001 Elsevier Science Ltd. All rights reserved.

Original languageEnglish
Pages (from-to)9273-9276
Number of pages3
JournalTetrahedron Letters
Volume42
DOIs
Publication statusPublished - 2001

Keywords

  • sponges
  • cyclic peptides
  • NMR
  • MS
  • cytotoxicity
  • ANTINEOPLASTIC AGENTS
  • HYMENIACIDON-SP
  • CARTERI
  • AXINASTATIN-4
  • CYCLOPEPTIDES
  • RESIDUES

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