What is the normal value of the neutrophil-to-lymphocyte ratio?

Patrice Forget* (Corresponding Author), Céline Khalifa, Jean-Philippe Defour, Dominique Latinne, Marie-Cécile Van Pel, Marc De Kock

*Corresponding author for this work

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

Background: Neutrophil-to-lymphocyte ratio (NLR) has proven its prognostic value in cardiovascular diseases, infections, inflammatory diseases and in several types of cancers. However, no cut-off has been proposed on the basis of reference values coming from healthy population.


Methods: Routine blood samples were obtained (n = 413) from workers (age: median 38, range: 21–66 years) involved in a health care prevention program, to determine means, standard deviations (SDs), 95% confidence intervals (95% CI), percentiles P2.5 and P97.5. A second independent sample of healthy volunteers is compared (n = 29).


Results: The mean NLR is 1.65 [±1.96 SD: 0.78–3.53] (95% CI [0.75–0.81] and [3.40–3.66]). In the second cohort (healthy control), the NLR values are in the same range, whichever the used analyzer. No NLR assessed in the validation series is out of the proposed limits.


Conclusions: We have identified that the normal NLR values in an adult, non-geriatric, population in good health are between 0.78 and 3.53. These data will help to define the normal values of the NLR.
Original languageEnglish
Article number12
Number of pages4
JournalBMC Research Notes
Volume10
Early online date3 Jan 2017
DOIs
Publication statusPublished - 2017

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Lymphocytes
Reference Values
Neutrophils
Cardiovascular Infections
Confidence Intervals
Health care
Population
Healthy Volunteers
Blood
Cardiovascular Diseases
Health
Delivery of Health Care
Neoplasms

Keywords

  • Neutrophil-to-lymphocyte ratio
  • Cells count
  • Laboratory testing
  • Reference values

Cite this

Forget, P., Khalifa, C., Defour, J-P., Latinne, D., Van Pel, M-C., & De Kock, M. (2017). What is the normal value of the neutrophil-to-lymphocyte ratio? BMC Research Notes, 10, [12]. https://doi.org/10.1186/s13104-016-2335-5

What is the normal value of the neutrophil-to-lymphocyte ratio? / Forget, Patrice (Corresponding Author); Khalifa, Céline; Defour, Jean-Philippe; Latinne, Dominique; Van Pel, Marie-Cécile; De Kock, Marc.

In: BMC Research Notes, Vol. 10, 12, 2017.

Research output: Contribution to journalArticle

Forget, P, Khalifa, C, Defour, J-P, Latinne, D, Van Pel, M-C & De Kock, M 2017, 'What is the normal value of the neutrophil-to-lymphocyte ratio?', BMC Research Notes, vol. 10, 12. https://doi.org/10.1186/s13104-016-2335-5
Forget, Patrice ; Khalifa, Céline ; Defour, Jean-Philippe ; Latinne, Dominique ; Van Pel, Marie-Cécile ; De Kock, Marc. / What is the normal value of the neutrophil-to-lymphocyte ratio?. In: BMC Research Notes. 2017 ; Vol. 10.
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