What is the risk of having offspring with cleft lip/palate in pre-maternal obese/overweight women when compared to pre-maternal normal weight women?: A systematic review and meta-analysis

Omoroghogho Maria Izedonmwen; Claudia Cunningham; Tatiana MacFarlane

doi:10.5037/jomr.2015.6101

What is the risk of having offspring with cleft lip/palate in pre-maternal obese/overweight women when compared to pre-maternal normal weight women? A systematic review and meta-analysis

Omoroghogho Maria Izedonmwen , Claudia Cunningham, Tatiana MacFarlane

Research output: Contribution to journal › Article › peer-review

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Abstract

Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women.

Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).

Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.

Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.

Original language	English
Article number	e1
Number of pages	22
Journal	Journal of Oral & Maxillofacial Research
Volume	6
Issue number	1
Early online date	30 Mar 2015
DOIs	https://doi.org/10.5037/jomr.2015.6101
Publication status	Published - 30 Mar 2015

Keywords

cleft palate
nonsyndromic cleft lip/palate
orofacial cleft 1

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What is the Risk of Having Offspring with Cleft Lip/Palate in Pre-Maternal Obese/Overweight Women When Compared to Pre-Maternal Normal Weight Women? A Systematic Review and Meta-Analysis
Copyright © Izedonmwen OM, Cunningham C, Macfarlane TV. Published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH (http://www.ejomr.org), 30 March 2015. This is an open-access article, first published in the JOURNAL OF ORAL & MAXILLOFACIAL RESEARCH, distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work and is properly cited. The copyright, license information and link to the original publication on (http://www.ejomr.org) must be included. https://creativecommons.org/licenses/by-nc-nd/3.0/
Final published version, 988 KBLicence: CC BY-ND

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What is the risk of having offspring with cleft lip/palate in pre-maternal obese/overweight women when compared to pre-maternal normal weight women? A systematic review and meta-analysis. / Izedonmwen , Omoroghogho Maria; Cunningham, Claudia ; MacFarlane, Tatiana.

In: Journal of Oral & Maxillofacial Research, Vol. 6, No. 1, e1, 30.03.2015.

Research output: Contribution to journal › Article › peer-review

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title = "What is the risk of having offspring with cleft lip/palate in pre-maternal obese/overweight women when compared to pre-maternal normal weight women?: A systematic review and meta-analysis",

abstract = "Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women.Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.",

keywords = "cleft palate, nonsyndromic cleft lip/palate , orofacial cleft 1",

author = "Izedonmwen, {Omoroghogho Maria} and Claudia Cunningham and Tatiana MacFarlane",

note = "ACKNOWLEDGMENTS AND DISCLOSURE STATEMENTS The authors declare no conflict of interest. This manuscript is based on the thesis presented for the degree of Masters in Science, Global Health and Management, Division of Applied Health Sciences, University of Aberdeen.",

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AU - Cunningham, Claudia

AU - MacFarlane, Tatiana

N1 - ACKNOWLEDGMENTS AND DISCLOSURE STATEMENTS The authors declare no conflict of interest. This manuscript is based on the thesis presented for the degree of Masters in Science, Global Health and Management, Division of Applied Health Sciences, University of Aberdeen.

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N2 - Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women.Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.

AB - Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women.Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.

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