Abstract
Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).
Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.
Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.
| Original language | English |
|---|---|
| Article number | e1 |
| Number of pages | 22 |
| Journal | Journal of Oral & Maxillofacial Research |
| Volume | 6 |
| Issue number | 1 |
| Early online date | 30 Mar 2015 |
| DOIs | |
| Publication status | Published - 30 Mar 2015 |
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Keywords
- cleft palate
- nonsyndromic cleft lip/palate
- orofacial cleft 1
Cite this
What is the risk of having offspring with cleft lip/palate in pre-maternal obese/overweight women when compared to pre-maternal normal weight women? A systematic review and meta-analysis. / Izedonmwen , Omoroghogho Maria; Cunningham, Claudia; MacFarlane, Tatiana.
In: Journal of Oral & Maxillofacial Research, Vol. 6, No. 1, e1, 30.03.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - What is the risk of having offspring with cleft lip/palate in pre-maternal obese/overweight women when compared to pre-maternal normal weight women?
T2 - A systematic review and meta-analysis
AU - Izedonmwen , Omoroghogho Maria
AU - Cunningham, Claudia
AU - MacFarlane, Tatiana
N1 - ACKNOWLEDGMENTS AND DISCLOSURE STATEMENTS The authors declare no conflict of interest. This manuscript is based on the thesis presented for the degree of Masters in Science, Global Health and Management, Division of Applied Health Sciences, University of Aberdeen.
PY - 2015/3/30
Y1 - 2015/3/30
N2 - Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women.Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.
AB - Objectives: The purpose of the study was to identify the risk of orofacial cleft in the offspring of women with pre-maternal obesity/overweight when compared with pre-maternal normal weight women.Material and Methods: MEDLINE and EMBASE were searched from 1980 to July 2014 for cohort, case control and cross sectional studies. BMI were categorized according to WHO recommendation: normal weight (BMI 18.5 - 24.9), overweight (BMI 25 - 29.9) and obese (BMI ≥ 30).Results: Six studies were identified; three case control studies which were used for the meta-analysis and two cross sectional studies and one cohort study. Compared with women of recommended BMI, obese women were at increased odds of pregnancy affected by CLP (OR = 1.16; 95% CI 1, 1.34) and CP (OR = 1.14; 95% CI 0.95, 1.37). Overweight women were also at increased odds of pregnancy affected by CLP (OR = 1.06; 95% CI 0.93, 1.21) but not CP (OR = 0.89; 95% CI 0.75, 1.06). The results of the risk ratios reported in the cross sectional and cohort studies were similar to the results of the meta-analysis.Conclusions: The results of this study reveal that there is an increased risk of having offspring with orofacial cleft in obese/overweight women. The reason for this association is not known. Although, the risk is small, it is important because of the increasing incidence of obesity.
KW - cleft palate
KW - nonsyndromic cleft lip/palate
KW - orofacial cleft 1
U2 - 10.5037/jomr.2015.6101
DO - 10.5037/jomr.2015.6101
M3 - Article
VL - 6
JO - Journal of Oral & Maxillofacial Research
JF - Journal of Oral & Maxillofacial Research
SN - 2029-283X
IS - 1
M1 - e1
ER -