Abstract
This review will discuss some of the recent advances in discovering immune genes in fish, in terms of their relevance to vaccine design and development. Particular emphasis will. be placed on the many cytokine and costimulatory molecules now known, with examples drawn from the mammalian literature as to their potential value for fish vaccinology. A new area of vaccine research will also be touched upon, where efficacious responses are elicited by inhibiting the natural negative regulators of immune responses, such as Treg cell products and SOCS proteins. (c) 2008 Elsevier Ltd. All rights reserved.
| Original language | English |
|---|---|
| Pages (from-to) | 409-416 |
| Number of pages | 8 |
| Journal | Fish & Shellfish Immunology |
| Volume | 25 |
| Issue number | 4 |
| Early online date | 16 May 2008 |
| DOIs | |
| Publication status | Published - Oct 2008 |
Keywords
- vaccination
- cytokines
- costimulatory molecules
- molecular adjuvants
- trout oncorhynchus-mykiss
- NF-Kappa-B
- grwoth-factor-beta
- flounder paralichthys-olivaceus
- colony-stimulating factor
- expression analysis
- teleost fish
- Japanese flounder
- functional-characterization
- antigen presentation
