Research Output 1970 2019

2019

ABC Transporter Genes Show Upregulated Expression in Drug Resistant Clinical Isolates of Candida auris: a Genome-Wide Characterization of ATP-Binding Cassette (ABC) Transporter Genes

Wasi, M., Khandelwal, N. K., Moorhouse, A. J., Nair, R., Vishwakarma, P., Bravo Ruiz, G., Ross, Z. K., Lorenz, A., Rudramurthy, S. M., Chakrabarti, A., Lynn, A. M., Gow, N. A. R., Mondal, A. K. & Prasad, R., 7 Jun 2019, (Accepted/In press) In : Frontiers in Microbiology.

Research output: Contribution to journalArticle

A Bioluminescence Reporter Assay for Retinoic Acid Control of Translation of the GluR1 Subunit of the AMPA Glutamate Receptor

Khatib, T., Whiting, A., Chisholm, D. R., Redfern, C., Muller, B. & McCaffery, P., 10 Apr 2019, In : Molecular Neurobiology.

Research output: Contribution to journalArticle

Open Access
Retinoic Acid Receptors
AMPA Receptors
Glutamate Receptors
Tretinoin
Ligands
5 Downloads (Pure)

A Bright Future for Fluorescence Imaging of Fungi in Living Hosts

Chapuis, A. F., Ballou, E. R. & MacCallum, D. M., 1 Jun 2019, In : Journal of Fungi. 5, 2, 9 p., 29.

Research output: Contribution to journalArticle

Open Access
File
Luminescent Proteins
Optical Imaging
Fungi
Fungal Proteins
Mycoses
1 Citation (Scopus)
6 Downloads (Pure)

Age at Onset of Walking in Infancy Is Associated With Hip Shape in Early Old Age

Ireland, A., Saunders, F. R., Muthuri, S. G., Pavlova, A., Hardy, R., Martin, K., Barr, R., Kuh, D., Aspden, R. M., Gregory, J. & Cooper, R., Mar 2019, In : Journal of Bone and Mineral Research. 34, 3, p. 455-463 9 p.

Research output: Contribution to journalArticle

Open Access
File
Age of Onset
Walking
Hip
Walkers
Femur Neck
4 Downloads (Pure)

A high-throughput screen for the identification of compounds that inhibit nematode gene expression by targeting spliced leader trans-splicing

Pandarakalam, G. C., Speake, M., McElroy, S., Alturkistani, A., Philippe, L., Pettitt, J., Muller, B. & Connolly, B., 5 Apr 2019, In : International Journal for Parasitology: Drugs and Drug Resistance. 10, p. 28-37 10 p.

Research output: Contribution to journalArticle

Open Access
File
Spliced Leader RNA
Trans-Splicing
Gene Targeting
Anthelmintics
Gene Expression
1 Citation (Scopus)
6 Downloads (Pure)

Alternative (backdoor) androgen production and masculinization in the human fetus

O'Shaughnessy, P. J., Antignac, J-P., Le Bizec, B., Morvan, M-L., Svechnikov, K., Söder, O., Savchuk, I., Monteiro, A., Soffientini, U., Johnston, Z. C., Bellingham, M., Hough, D., Walker, N., Filis, P. & Fowler, P., 14 Feb 2019, In : PLoS Biology. 17, 2, e3000002.

Research output: Contribution to journalArticle

Open Access
File
androsterone
Androsterone
masculinization
androgens
Androgens
4 Downloads (Pure)
Open Access
File
Antigen Receptors
Transgenic Mice
Autoimmune Diseases
Arthritis
Tumor Necrosis Factor-alpha

A New Generation of Selective Androgen Receptor Degraders: Our Initial Design, Synthesis, and Biological Evaluation of New Compounds with Enzalutamide-Resistant Prostate Cancer Activity

Hwang, D-J., He, Y., Ponnusamy, S., Mohler, M. L., Thiyagarajan, T., McEwan, I. J., Narayanan, R. & Miller, D. D., 2019, In : Journal of Medicinal Chemistry. 62, 2, p. 491-511 20 p.

Research output: Contribution to journalArticle

Androgen Receptors
Prostatic Neoplasms
Androgen Receptor Antagonists
Castration
Cyclization

An ex-vivo human skin model to study superficial fungal infections

Corzo-Leon, D. E., Munro, C. A. & MacCallum, D. M., Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1172.

Research output: Contribution to journalArticle

Open Access
File
Mycoses
Skin
Infection
Microscopy
Animal Models
1 Citation (Scopus)
5 Downloads (Pure)

A reciprocal feedback between the PDZ binding kinase and androgen receptor drives prostate cancer

Warren, A. Y., Massie, C. E., Watt, K., Luko, K., Orafidiya, F., Selth, L. A., Mohammed, H., Chohan, B. S., Menon, S., Baridi, A., Zhao, W., Escriu, C., D'Santos, C., Taylor, C., Qureshi, A., Zecchini, V. R., Shaw, G. L., Dehm, S. M., Mills, I. G., Carroll, J. S. & 5 othersTilley, W. D., McEwan, I. J., Baniahmad, A., Neal, D. E. & Asim, M., 2019, In : Oncogene. 38, p. 1136-1150 15 p.

Research output: Contribution to journalArticle

Open Access
File
Androgen Receptors
Prostatic Neoplasms
PDZ-binding kinase
Systems Biology
Proteome
4 Downloads (Pure)

A retino-retinal projection guided by Unc5c emerged in species with retinal waves

Murcia-Belmonte, V., Coca, Y., Vegar, C., Negueruela, S., de Juan, C., Valiño, A. J., Sala, S., DaSilva, R., Kania, A., Borrell, V., Martinez, L. M., Erskine, L. & Herrera, E., Apr 2019, In : Current Biology. 29, 7, p. 1149-1160 12 p.

Research output: Contribution to journalArticle

Open Access
File
axons
Axons
retina
Retina
Retinal Ganglion Cells
4 Downloads (Pure)

Bacteroides thetaiotaomicron Ameliorates Colon Inflammation in Preclinical Models of Crohn's Disease

Delday, M., Mulder, I., Logan, E. T. & Grant, G., 1 Jan 2019, In : Inflammatory Bowel Diseases. 25, 1, p. 85-96 11 p.

Research output: Contribution to journalArticle

Open Access
File
Crohn Disease
Colon
Inflammatory Bowel Diseases
Dextran Sulfate
Inflammation
Molecular Pathology
National Cancer Institute (U.S.)
Clinical Trials
Pathology
Research

Batrachochytrium salamandrivorans

Farrer, R. A., 22 May 2019, In : Trends in Microbiology. 2 p.

Research output: Contribution to journalArticle

5 Downloads (Pure)

CAMKII as a therapeutic target for growth factor-induced retinal and choroidal neovascularisation

Ashraf, S., Bell, S., O'Leary, C., Canning, P., Micu, I., Fernandez, J. A., O'Hare, M., Barabas, P., McCauley, H., Brazil, D. P., Stitt, A. W., McGeown, J. G. & Curtis, T. M., 21 Mar 2019, In : JCI Insight. 4, 6, e122442.

Research output: Contribution to journalArticle

Open Access
File
Retinal Neovascularization
Choroidal Neovascularization
Calcium-Calmodulin-Dependent Protein Kinases
Pathologic Neovascularization
Intercellular Signaling Peptides and Proteins

Candida albicans: Microbe of the month

Wilson, D., Feb 2019, In : Trends in Microbiology. 27, 2, p. 188-189 2 p.

Research output: Contribution to journalArticle

1 Citation (Scopus)

CARD9+ microglia promote antifungal immunity via IL-1β- and CXCL1-mediated neutrophil recruitment

Drummond, R. A., Swamydas, M., Oikonomou, V., Zhai, B., Dambuza, I., Schaefer, B. C., Bohrer, A. C., Mayer-Barber, K. D., Lira, S. A., Iwakura, Y., Filler, S. G., Brown, G. D., Hube, B., Naglik, J. R., Hohl, T. M. & Lionakis, M. S., May 2019, In : Nature Immunology. 20, p. 559-570 12 p.

Research output: Contribution to journalArticle

Neutrophil Infiltration
Microglia
Interleukin-1
Immunity
Central Nervous System
5 Downloads (Pure)

CDP-choline accumulation in breast and colorectal cancer cells treated with a GSK-3-targeting inhibitor

Phyu, S. M., Tseng, C-C. & Smith, T. A. D., Apr 2019, In : Magnetic Resonance Materials in Physics, Biology and Medicine. 32, 2, p. 227-235 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cytidine Diphosphate Choline
Glycogen Synthase Kinase 3
Colorectal Neoplasms
Breast Neoplasms
Lipids

Comparative genomics and genome biology of Campylobacter showae

Hsu, T., Gemmell, M. R., Franzosa, E. A., Berry, S. H., Mukhopadhya, I., Hansen, R., Michaud, M., Nielsen, H., Miller, W. G., Nielsen, H., Bajaj-Elliott, M., Huttenhower, C., Garrett, W. S. & Hold, G. L., 2019, In : Emerging Microbes and Infections. 8, 1, p. 827-840 14 p.

Research output: Contribution to journalArticle

Open Access
File
Campylobacter
Genomics
Genome
Genes
CRISPR-Associated Proteins
6 Downloads (Pure)
Open Access
File
Aging of materials
Brain
Neurodegenerative diseases
Complex networks
Magnetic resonance
5 Downloads (Pure)

DNA sequence differences and temperature are determinants of meiotic recombination outcome

Brown, S. D., Asogwa, M. N., Jézéquel, M., Audoynaud, C., Mpaulo, S. J., Whitby, M. C. & Lorenz, A., 5 Mar 2019, (Accepted/In press) In : bioRxiv.

Research output: Contribution to journalArticle

Open Access
File
Genetic Recombination
Temperature
Chromosomes
DNA Helicases
Chromosome Segregation

Effective mismatch repair depends on timely control of PCNA retention on DNA by the Elg1 complex

Paul Solomon Devakumar, L. J., Gaubitz, C., Lundblad, V., Kelch, B. A. & Kubota, T., 22 May 2019, In : Nucleic Acids Research.

Research output: Contribution to journalArticle

Open Access
DNA Mismatch Repair
Proliferating Cell Nuclear Antigen
DNA
Mutation Rate
Phenotype
3 Downloads (Pure)
Open Access
File
Isometric Contraction
Vibration
Lower Extremity
Muscles
Quadriceps Muscle

Effects of Liraglutide and Fenretinide treatments on the diabetic phenotype of neuronal human BACE1 knock-in mice

Dekeryte, R., Hull, C., Plucinska, K., Khan, S., Kamli-Salino, S., Mody, N., Morrice, N., McLaughlin, C., Gault, V., Platt, B. & Delibegovic, M., 16 May 2019, In : Biochemical Pharmacology. 166, p. 222-230 9 p.

Research output: Contribution to journalArticle

Fenretinide
Phenotype
Dipeptidyl Peptidase 4
Glucose
Retinol-Binding Proteins
Chemokine Receptors
Cell Division
Electric Stimulation
Up-Regulation
Endothelial Cells
Electrochemistry
Electric fields
Electrodes
Intercalation
Insulating materials

Enzymatic radiosynthesis of a 18F-Glu-Ureido-Lys ligand for the prostate-specific membrane antigen (PSMA)

Lowe, P. T., Dall'Angelo, S., Fleming, I. N., Piras, M., Zanda, M. & O'Hagan, D., 2019, In : Organic & Biomolecular Chemistry. 17, 6, p. 1480-1486 7 p.

Research output: Contribution to journalArticle

antigens
Ligands
membranes
ligands
cancer

Erratum to: Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis (Nature Communications, (2018), 9, 1, (5288), 10.1038/s41467-018-07738-1)

Rudkin, F. M., Raziunaite, I., Workman, H., Essono, S., Belmonte, R., MacCallum, D. M., Johnson, E. M., Silva, L., Palma, A. S., Feizi, T., Jensen, A., Erwig, L. P. & Gow, N. A. R., 18 Jan 2019, In : Nature Communications. 10, 394.

Research output: Contribution to journalComment/debate

Open Access
Candida
Candidiasis
antibodies
Phagocytosis
Anti-Idiotypic Antibodies

Evaluation of high resolution melting for rapid differentiation of Phytophthora hybrids and their parental species

Ratti, M. F., Farrer, R. A., Cano, L. M., Faedda, R. & Goss, E., 5 Apr 2019, In : Plant Disease.

Research output: Contribution to journalArticle

Phytophthora
melting
pathogens
wild plants
Solanaceae
4 Downloads (Pure)

Exophiala angulospora infection in hatchery reared lumpfish (Cyclopterus lumpus) broodstock

Saraiva, M., Beckmann, M. J., Pflaum, S., Pearson, M., Carcajona, D., Treasurer, J. W. & Van West, P., Mar 2019, In : Journal of Fish Diseases. 42, 3, p. 335-343 9 p.

Research output: Contribution to journalArticle

Open Access
File
Cyclopterus
Cylopterus lumpus
Exophiala
breeding stock
hatchery
4 Downloads (Pure)

Genomic and non-genomic pathways are both crucial for peak induction of neurite outgrowth by retinoids

Khatib, T., Marini, P., Nunna, S., Chisholm, D. R., Whiting, A., Redfern, C., Greig, I. R. & McCaffery, P., 2 May 2019, In : Cell Communication and Signaling. 17, 16 p., 40.

Research output: Contribution to journalArticle

Open Access
File
Phosphorylation
Retinoids
Tretinoin
Assays
Retinoic Acid Receptors
4 Downloads (Pure)

Geographic patterns of mtDNA and Z-linked sequence variation in the Common Chiffchaff and the ‘chiffchaff complex’

Raković, M., Neto, J. M., Lopes, R. J., Koblik, E. A., Fadeev, I. V., Lohman, Y. V., Aghayan, S. A., Boano, G., Pavia, M., Perlman, Y., Kiat, Y., Dov, A. B., Collinson, J. M., Voelker, G. & Drovetski, S. V., 4 Jan 2019, In : PloS ONE. 14, 1, 20 p., e0210268.

Research output: Contribution to journalArticle

Open Access
File
Mitochondrial DNA
Birds
mitochondrial DNA
Genes
Canary Islands
3 Downloads (Pure)

Glyoxylate cycle gene ICL1 is essential for the metabolic flexibility and virulence of Candida glabrata

Chew, S. Y., Ho, K. L., Cheah, Y. K., Ng, T. S., Sandai, D., Brown, A. J. P. & Lung, L. T. T., 26 Feb 2019, In : Scientific Reports. 9, 1, p. 2843 11 p., 2843.

Research output: Contribution to journalArticle

Open Access
File
Candida glabrata
Virulence
Genes
Carbon
Macrophages
7 Citations (Scopus)

Guidance of retinal axons in mammals

Herrera, E., Erskine, L. & Morenilla-Palao, C., 30 Jan 2019, In : Seminars in Cell and Developmental Biology. 85, p. 48-59 12 p.

Research output: Contribution to journalArticle

Axons
Retina
Mammals
Retinal Ganglion Cells
Brain

Human RIF1-Protein Phosphatase 1 prevents degradation and breakage of nascent DNA on replication stalling

Garzón, J., Ursich, S., Lopes, M., Hiraga, S. & Donaldson, A. D., 28 May 2019, In : Cell Reports. 27, 9, p. 2558-2566 9 p.

Research output: Contribution to journalArticle

Open Access
File
Protein Phosphatase 1
DNA Replication
Degradation
DNA
Genomic Instability

Identification and validation of DOCK4 as a potential biomarker for risk of bone metastasis development in patients with early breast cancer

Westbrook, J. A., Wood, S. L., Cairns, D., McMahon, K., Gahlaut, R., Thygesen, H., Shires, M., Roberts, S., Marshall, H., Oliva, M. R., Dunning, M. J., Hanby, A. M., Selby, P. J., Speirs, V., Mavria, G., Coleman, R. E. & Brown, J. E., Mar 2019, In : The Journal of pathology. 247, 3, p. 381-391 11 p.

Research output: Contribution to journalArticle

zoledronic acid
Cytokinesis
Bone Development
Biomarkers
Breast Neoplasms
5 Citations (Scopus)
3 Downloads (Pure)

Identification of Novel Loci Associated With Hip Shape: A Meta‐Analysis of Genomewide Association Studies

Baird, D. A., Evans, D. S., Kamanu, F. K., Gregory, J. S., Saunders, F. R., Giuraniuc, C. V., Barr, R. J., Aspden, R. M., Jenkins, D., Kiel, D. P., Orwoll, E. S., Cummings, S. R., Lane, N. E., Mullin, B. H., Williams, F. MK., Richards, J. B., Wilson, S. G., Spector, T. D., Faber, B. G., Lawlor, D. A. & 10 othersGrundberg, E., Ohlsson, C., Pettersson-Kymmer, U., Capellini, T. D., Richard, D., Beck, T. J., Evans, D. M., Paternoster, L., Karasik, D. & Tobias, J. H., Feb 2019, In : Journal of Bone and Mineral Research. 34, 2, p. 241-251 11 p.

Research output: Contribution to journalArticle

Open Access
File
Hip
Hip Osteoarthritis
Osteoporotic Fractures
Hip Fractures
X-Rays
4 Citations (Scopus)

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Gado, F., Di Cesare Mannelli, L., Lucarini, E., Bertini, S., Cappelli, E., Digiacomo, M., Stevenson, L. A., Macchia, M., Tuccinardi, T., Ghelardini, C., Pertwee, R. G. & Manera, C., 10 Jan 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 276-287 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Cannabinoid Receptors
Neuralgia
Allosteric Site
Ligands
4 Downloads (Pure)

Immediate visualization of recombination events and chromosome segregation defects in fission yeast meiosis

Li, D., Roca, M., Yuecel, R. & Lorenz, A., 9 Feb 2019, In : Chromosoma. 12 p.

Research output: Contribution to journalArticle

Open Access
File
Chromosome Segregation
Schizosaccharomyces
Meiosis
Genetic Recombination
Phenotype

Immune response modulation upon sequential heterogeneous co-infection with Tetracapsuloides bryosalmonae and VHSV in brown trout (Salmo trutta)

Gorgoglione, B., Taylor, N. G. H., Holland, J. W., Feist, S. W. & Secombes, C. J., May 2019, In : Fish and Shellfish Immunology. 88, p. 375-390 16 p.

Research output: Contribution to journalArticle

Salmo trutta
immune response
mixed infection
Fish
Modulation

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

Research output: Contribution to journalArticle

Synucleins
Cholinergic Agents
Transgenic Mice
Acetylcholine
Choline O-Acetyltransferase
4 Downloads (Pure)

Inhibition of classical and alternative modes of respiration in Candida albicans leads to cell wall remodelling and increased macrophage recognition

Duvenage, L., Walker, L. A., Bojarczuk, A., Johnston, S. A., MacCallum, D. M., Munro, C. A. & Gourlay, C. W., 29 Jan 2019, In : mBio. 10, 1, e02535-18.

Research output: Contribution to journalArticle

Open Access
File
Candida albicans
Cell Wall
Respiration
Macrophages
Virulence

Interaction of the mechanosensitive channel, MscS, with the membrane bilayer through lipid intercalation into grooves and pockets

Rasmussen, T., Rasmussen, A., Yang, L., Kaul, C., Black, S., Galbiati, H., Conway, S. J., Miller, S., Blount, P. & Booth, I. R., 27 May 2019, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

5 Downloads (Pure)

Long-term exposure to chemicals in sewage sludge fertilizer alters liver lipid content in females and cancer marker expression in males

Filis, P., Walker, N., Robertson, L., Eaton-Turner, E., Ramona, L., Bellingham, M., Amezaga, M. R., Zhang, Z., Mandon-Pepin, B., Evans, N. P., Sharpe, R. M., Cotinot, C., Rees, W. D., O'Shaughnessy, P. & Fowler, P. A., Mar 2019, In : Environment International. 124, p. 98-108 10 p.

Research output: Contribution to journalArticle

Open Access
File
cancer
lipid
fertilizer
protein
culling
4 Downloads (Pure)

Low Citrate Synthase Activity Is Associated with Glucose Intolerance and Lipotoxicity

Alhindi, Y., Vaanholt, L. M., Al-Tarrah, M., Gray, S. R., Speakman, J. R., Hambly, C., Alanazi, B. S., Gabriel, B. M., Lionikas, A. & Ratkevicius, A., 1 Jan 2019, In : Journal of Nutrition and Metabolism. 2019, 14 p., 8594825.

Research output: Contribution to journalArticle

Open Access
File
Citrate (si)-Synthase
citrate (si)-synthase
Glucose Intolerance
glucose
mice

Mammalian innate immunity to fungal infection

Brown, G. D. & Wilson, D., May 2019, In : Seminars in Cell & Developmental Biology. 89, p. 1-2 2 p.

Research output: Contribution to journalEditorial

Immune Evasion
Infection
Psychological Adaptation
Life Style
Immunity

Methods and Models in Alzheimer's Disease

Platt, B., 1 May 2019, In : Journal of Neuroscience Methods. 319, p. 1 1 p.

Research output: Contribution to journalEditorial

Alzheimer Disease
Research
Dementia
Early Diagnosis
Clinical Trials
3 Citations (Scopus)
3 Downloads (Pure)

Microbiota Sensing by Mincle-Syk Axis in Dendritic Cells Regulates Interleukin-17 and -22 Production and Promotes Intestinal Barrier Integrity

Martínez-López, M., Iborra, S., Conde-Garrosa, R., Mastrangelo, A., Danne, C., Mann, E. R., Reid, D. M., Gaboriau-Routhiau, V., Chaparro, M., Lorenzo, M. P., Minnerup, L., Saz-Leal, P., Slack, E., Kemp, B., Gisbert, J. P., Dzionek, A., Robinson, M. J., Rupérez, F. J., Cerf-Bensussan, N., Brown, G. D. & 3 othersBernardo, D., LeibundGut-Landmann, S. & Sancho, D., 19 Feb 2019, In : Immunity. 50, 2, p. 446-461 15 p.

Research output: Contribution to journalArticle

Open Access
File
Interleukin-17
Microbiota
Dendritic Cells
Interleukin-23 Subunit p19
Inflammation