Abstract
Background: Three daily portions of whole-grain foods could lower cardiovascular disease risk, but a comprehensive intervention trial was needed to confirm this recommendation.
Objectives: We aimed to assess the effects of consumption of 3 daily portions of whole-grain foods (provided as only wheat or a mixture of wheat and oats) on markers of cardiovascular disease risk in relatively high-risk individuals.
Design: This was a randomized controlled dietary trial in middle-aged healthy individuals. After a 4-wk run-in period with a refined diet, we randomly allocated volunteers to a control (refined diet), wheat, or wheat + oats group for 12 wk. The primary outcome was a reduction of cardiovascular disease risk factors by dietary intervention with whole grains, which included lipid and inflammatory marker concentrations, insulin sensitivity, and blood pressure.
Results: We recruited a total of 233 volunteers; 24 volunteers withdrew, and 3 volunteers were excluded. Systolic blood pressure and pulse pressure were significantly reduced by 6 and 3 mm Hg, respectively, in the whole-grain foods groups compared with the control group. Systemic markers of cardiovascular disease risk remained unchanged apart from cholesterol concentrations, which decreased slightly but significantly in the refined group.
Conclusions: Daily consumption of 3 portions of whole-grain foods can significantly reduce cardiovascular disease risk in middle-aged people mainly through blood pressure lowering mechanisms. The observed decrease in systolic blood pressure could decrease the incidence of coronary artery disease and stroke by >= 15% and 25%, respectively. This trial was registered at clinicaltrials.gov as ISRCTN27657880. Am J Clin Nutr 2010;92:733-40.
Original language | English |
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Pages (from-to) | 733-740 |
Number of pages | 8 |
Journal | The American Journal of Clinical Nutrition |
Volume | 92 |
Issue number | 4 |
Early online date | 4 Aug 2010 |
DOIs | |
Publication status | Published - Oct 2010 |
Keywords
- ischemic-heart-disease
- dietary fiber intake
- c-reactive protein
- oat beta-glucan
- hypercholesterolemic adults
- insulin-resistance
- women
- metaanalysis
- cholesterol
- lipids
- intervention study
- blood pressure
- CVD risk
- whole grain