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Research Output

2020

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G. & Niewiadomska, G., 30 Mar 2020, In : Brain Communications.

Research output: Contribution to journalArticle

Open Access

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 19 May 2020, In : Journal of Alzheimer's Disease. 75, 2, p. 501-519 19 p.

Research output: Contribution to journalArticle

Open Access
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Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R. & Wischik, C. M., 31 Mar 2020, In : Current Alzheimer Research. 17, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 18 May 2020, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W-F., Wischik, C. M. & Serpell, L. C., Mar 2020, In : FEBS LETTERS. 594, 5, p. 944-950 7 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
1 Downloads (Pure)
2019

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

Research output: Contribution to journalArticle

Open Access
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5 Citations (Scopus)
5 Downloads (Pure)

Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

Research output: Contribution to journalArticle

Open Access
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1 Citation (Scopus)
2 Downloads (Pure)

Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J. & Luna-Muñoz, J., 17 Sep 2019, In : Journal of Alzheimer's Disease. 71, 2, p. 631-645 15 p.

Research output: Contribution to journalArticle

Open Access
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3 Downloads (Pure)
2018

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
25 Downloads (Pure)
Open Access
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7 Citations (Scopus)
12 Downloads (Pure)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
9 Downloads (Pure)
Open Access
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9 Citations (Scopus)
13 Downloads (Pure)
2017

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 24 Nov 2017, In : Journal of Molecular Biology. 429, 23, p. 3650-3665 16 p.

Research output: Contribution to journalArticle

Open Access
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16 Citations (Scopus)
15 Downloads (Pure)

LMTM DECREASES α-SYNUCLEIN PATHOLOGY AND REDUCES BEHAVIOURAL DEFECTS IN α-SYNUCLEIN TRANSGENIC MICE

Schwab, K., Frahm, S., Magbagbeolu, M., A. Goatman, E., R. Harrington, C., M. Wischik, C. & Theuring, F., 1 Jul 2017, In : Alzheimer's and Dementia. 13, 7 Suppl., p. P945-P945 1 p., P3-041.

Research output: Contribution to journalAbstract

Monoaminergic Neuropathology in Alzheimer's disease

Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., Silva, R. D., Giovanni, G. D., Wischik, C. M. & Hof, P. R., Apr 2017, In : Progress in Neurobiology. 151, p. 101-138 38 p.

Research output: Contribution to journalArticle

Open Access
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69 Citations (Scopus)
15 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
18 Downloads (Pure)
2016

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

Lai, R. Y. K., Harrington, C. R. & Wischik, C. M., 8 Apr 2016, In : Biomolecules. 6, 2, p. 1-19 19 p., 19.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
5 Downloads (Pure)

Assays for the Screening and Characterization of Tau Aggregation Inhibitors

Rickard, J. E., Horsley, D., Wischik, C. M. & Harrington, C. R., 15 Dec 2016, Tau Protein: Methods and Protocols. Smet-Nocca, C. (ed.). Springer , Vol. 1523. p. 129-140 12 p. (Methods in Molecular Biology; vol. 1523).

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Citations (Scopus)

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., Dec 2016, In : The Lancet. 388, 10062, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Open Access
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123 Citations (Scopus)
6 Downloads (Pure)

Inhibition of Tau Aggregation as a Basis for Treatment and Prevention of Alzheimer's Disease

Wischik, C. M., Storey, J. M. D., Wischik, D. J. & Harrington, C. R., 15 Jun 2016, Developing Therapeutics for Alzheimer's Disease: Progress and Challenges. Wolfe, M. S. (ed.). Elsevier Inc., p. 385-436 52 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Tau Protein Hyperphosphorylation and Aggregation in Alzheimer’s Disease and Other Tauopathies, and Possible Neuroprotective Strategies

Šimić, G., Babić Leko, M., Wray, S., Harrington, C., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., de Silva, R., Giovanni, G. D., Wischik, C. & Hof, P. R., Mar 2016, In : Biomolecules. 6, 1, 27 p., 6.

Research output: Contribution to journalReview article

Open Access
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175 Citations (Scopus)
12 Downloads (Pure)
2015
Open Access
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47 Citations (Scopus)
8 Downloads (Pure)
64 Citations (Scopus)

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G. & 1 others, Theuring, F., Jun 2015, In : Cellular and Molecular Life Sciences. 72, 11, p. 2199-2222 24 p.

Research output: Contribution to journalArticle

Open Access
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20 Citations (Scopus)
5 Downloads (Pure)

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F. & Riedel, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 353-368 16 p.

Research output: Contribution to journalArticle

Open Access
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42 Citations (Scopus)
10 Downloads (Pure)

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A. & Harrington, C. R., 22 Jan 2015, In : Journal of Alzheimer's Disease. 44, 2, p. 705-720 16 p.

Research output: Contribution to journalArticle

Open Access
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134 Citations (Scopus)
5 Downloads (Pure)

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B. & Luna-Muñoz, J., 11 Feb 2015, In : Frontiers in Neuroscience. 9, 10 p., 33.

Research output: Contribution to journalArticle

Open Access
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22 Citations (Scopus)
7 Downloads (Pure)
2014

Tau-aggregation inhibitor therapy for Alzheimer's disease

Wischik, C. M., Harrington, C. R. & Storey, J. M. D., 15 Apr 2014, In : Biochemical Pharmacology. 88, 4, p. 529-539 11 p.

Research output: Contribution to journalArticle

Open Access
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152 Citations (Scopus)
6 Downloads (Pure)
2013

Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function

Wasik, U., Schneider, G., Mietelska-Porowska, A., Mazurkiewicz, M., Fabczak, H., Weis, S., Zabke, C., Harrington, C. R., Filipek, A. & Niewiadomska, G., May 2013, In : Neurobiology of Aging. 34, 5, p. 1380-1388 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2012

The molecular pathology of Alzheimer's disease

Harrington, C. R., Feb 2012, In : Neuroimaging Clinics of North America. 22, 1, p. 11-22 12 p.

Research output: Contribution to journalLiterature review

29 Citations (Scopus)
2011
File
9 Downloads (Pure)
2 Citations (Scopus)
2010

3,6-Disubstituted xanthylium salts

Clunas, S., Storey, J. M. D., Horsley, D., Rickard, J. E., Harrington, C. R. & Wischik, C. M., 17 Jun 2010, IPC No. WO2010/067078

Research output: Patent

Ligands for aggregated tau molecules: WO2010034982

Kemp, S. J., Storey, J. M. D., Rickard, J. E., Harrington, C. R., Horsley, D., Wischik, C. M., Clunas, S. & Heinrich, T., 1 Apr 2010, Patent No. WO2010/034982

Research output: Patent

File
12 Downloads (Pure)

Rationale for tau aggregation inhibitor therapy in Alzheimer's disease and other tauopathies

Wischik, C. M., Wischik, D. J., Storey, J. M. D. & Harrington, C. R., 2010, Emerging drugs and targets for Alzheimer's disease: Volume 1: Beta-Amyloid, Tau Protein and Glucose Metabolism. Martinez, A. (ed.). Cambridge, Vol. 1. p. 210-232 23 p. (RSC Drug Discovery Series).

Research output: Chapter in Book/Report/Conference proceedingChapter

File
133 Downloads (Pure)
2009

Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M. & CC75C Collaboration Grp, 16 Dec 2009, In : The Scientific World Journal. 9, p. 1463-1475 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
36 Downloads (Pure)

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Deiana, S., Harrington, C. R., Wischik, C. M. & Riedel, G., Jan 2009, In : Psychopharmacology. 202, 1-3, p. 53-65 13 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
104 Downloads (Pure)

Therapeutic Use of Diaminophenothiazines: WO2009044127

Wischik, C. M., Damon J., W., Storey, J. M. D. & Harrington, C. R., 9 Apr 2009, IPC No. WO2009/044127

Research output: Patent

File
4 Downloads (Pure)
File
2 Downloads (Pure)
2008

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M. & Mena, R., Nov 2008, In : Acta Neuropathologica. 116, 5, p. 507-515 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2007

Inhibitors of protein aggregation: WO2007110629

Wischik, C. M., Rickard, J. E., Horsley, D. & Harrington, C. R., 4 Oct 2007, Patent No. WO2007110629

Research output: Patent

File
3 Downloads (Pure)
2005
4 Citations (Scopus)

Inhibition of tau-tau-association

Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M. & Klug, A., 2005, Patent No. US Patent 6,953,794B2; Granted 11/10/05

Research output: Patent

2004

Alzheimer's disease

Wischik, C. M., Harrington, C. R. & Roth, M., 2004, The Oxford Companion to The Mind. Gregory, R. L. (ed.). 2 ed. Oxford: Oxford University Press, p. 24-27 4 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2003

Naphthoquinone-type inhibitors of protein aggregation

Wischik, C. M., Horsley, D., Rickard, J. E. & Harrington, C. R., 2003, Patent No. WO 03/007933; published 30.01.03

Research output: Patent

2002

Inhibition of tau-tau-association

Wischik, C. M., Edwards, P. C., Harrington, C. R., Roth, M. & Klug, A., 2002, Patent No. EP0817969; Application Granted 20/06/02

Research output: Patent

Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics

Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R. & Wischik, C. M., 14 Jan 2002, In : Neuroscience Letters. 317, 3, p. 161-165 5 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)