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2020

Cholinergic and inflammatory phenotypes in transgenic tau mouse models of Alzheimer’s Disease and Frontotemporal Lobar Degeneration

Cranston, A. L., Wysocka, A., Steczkowska, M., Zadrozny, M., Palasz, E., Harrington, C. R., Theuring, F., Wischik, C., Riedel, G. & Niewiadomska, G., 30 Mar 2020, In : Brain Communications.

Research output: Contribution to journalArticle

Open Access

Concentration-Dependent Activity of Hydromethylthionine on Clinical Decline and Brain Atrophy in a Randomized Controlled Trial in Behavioral Variant Frontotemporal Dementia

Shiells, H., Schelter, B. O., Bentham, P., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Wischik, D. J., Riedel, G., Gauthier, S., Jia, J., Moebius, H. J., Hardlund, J., Kipps, C. M., Kook, K., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 19 May 2020, In : Journal of Alzheimer's Disease. 75, 2, p. 501-519 19 p.

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Mechanisms of anticholinesterase interference with tau aggregation inhibitor activity in a tau-transgenic mouse model

Riedel, G., Klein, J., Niewiadomska, G., Kondak, C., Schwab, K., Lauer, D., Magbagbeolu, M., Steczkowska, M., Zadrozny, M., Wydrych, M., Cranston, A., Melis, V., Santos, R. X., Theuring, F., Harrington, C. R. & Wischik, C. M., 31 Mar 2020, In : Current Alzheimer Research. 17, 3, p. 285-296 12 p.

Research output: Contribution to journalArticle

Paired helical filament forming region of tau (297-391) influences endogenous tau protein and accumulates in acidic compartments in human neuronal cells

Pollack, S. J., Trigg, J., Khanom, T., Biasetti, L., Marshall, K. E., Al-Hilaly, Y. K., Rickard, J. E., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 18 May 2020, (Accepted/In press) In : Journal of Molecular Biology.

Research output: Contribution to journalArticle

Tau (297-391) forms filaments that structurally mimic the core of paired helical filaments in Alzheimer's disease brain

Al-Hilaly, Y. K., Foster, B. E., Biasetti, L., Lutter, L., Pollack, S. J., Rickard, J. E., Storey, J. M. D., Harrington, C. R., Xue, W-F., Wischik, C. M. & Serpell, L. C., Mar 2020, In : FEBS LETTERS. 594, 5, p. 944-950 7 p.

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Open Access
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1 Citation (Scopus)
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2019

Concentration-Dependent Activity of Hydromethylthionine on Cognitive Decline and Brain Atrophy in Mild to Moderate Alzheimer’s Disease

Schelter, B. O., Shiells, H. C., Baddeley, T. C., Rubino, C. M., Ganesan, H., Hammel, J., Vuksanovic, V., Staff, R. T., Murray, A. D., Bracoud, L., Riedel, G., Gauthier, S., Jia, J., Bentham, P., Kook, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., 26 Nov 2019, In : Journal of Alzheimer's Disease. 72, 3, p. 931-946 16 p.

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5 Citations (Scopus)
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Increased Cholinergic Response in α-Synuclein Transgenic Mice (h-α-synL62)

König, M., Berlin, B., Schwab, K., Frahm, S., Theuring, F., Wischik, C. M., Harrington, C. R., Riedel, G. & Klein, J., 2019, In : ACS Chemical Neuroscience. 10, 4, p. 1915-1922 8 p.

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Open Access
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1 Citation (Scopus)
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Phospho-Tau Protein Expression in the Cell Cycle of SH-SY5Y Neuroblastoma Cells: A Morphological Study

Flores-Rodríguez, P., Harrington, C. R., Wischik, C. M., Ibarra-Bracamontes, V., Zarco, N., Navarrete, A., Martínez-Maldonado, A., Guadarrama-Ortíz, P., Villanueva-Fierro, I., Ontiveros-Torres, M. A., Perry, G., Alonso, A. D., Florán-Garduño, B., Segovia, J. & Luna-Muñoz, J., 17 Sep 2019, In : Journal of Alzheimer's Disease. 71, 2, p. 631-645 15 p.

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2018

Alpha-Synuclein transgenic mice, h-α-SynL62, display α-Syn aggregation and a dopaminergic phenotype reminiscent of Parkinson's disease

Frahm, S., Melis, V., Horsley, D., Rickard, J. E., Riedel, G., Fadda, P., Scherma, M., Harrington, C. R., Wischik, C. M., Theuring, F. & Schwab, K., 26 Feb 2018, In : Behavioural Brain Research. 339, p. 153-168 16 p.

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Open Access
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10 Citations (Scopus)
25 Downloads (Pure)
Open Access
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7 Citations (Scopus)
12 Downloads (Pure)

Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

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Open Access
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7 Citations (Scopus)
9 Downloads (Pure)
Open Access
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9 Citations (Scopus)
13 Downloads (Pure)
2017

Alzheimer's Disease-like Paired Helical Filament Assembly from Truncated Tau Protein Is Independent of Disulfide Crosslinking

Al-Hilaly, Y. K., Pollack, S. J., Vadukul, D., Citossi, F., Rickard, J. E., Simpson, M., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 24 Nov 2017, In : Journal of Molecular Biology. 429, 23, p. 3650-3665 16 p.

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Open Access
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16 Citations (Scopus)
15 Downloads (Pure)

Monoaminergic Neuropathology in Alzheimer's disease

Šimić, G., Leko, M. B., Wray, S., Harrington, C. R., Delalle, I., Jovanov-Milošević, N., Bažadona, D., Buée, L., Silva, R. D., Giovanni, G. D., Wischik, C. M. & Hof, P. R., Apr 2017, In : Progress in Neurobiology. 151, p. 101-138 38 p.

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Open Access
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69 Citations (Scopus)
16 Downloads (Pure)

Potential of Low Dose Leuco-Methylthioninium Bis(Hydromethanesulphonate) (LMTM) Monotherapy for Treatment of Mild Alzheimer’s Disease: Cohort Analysis as Modified Primary Outcome in a Phase III Clinical Trial

Wilcock, G. K., Gauthier, S., Frisoni, G. B., Jia, J., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Schelter, B. O., Wischik, D. J., Davis, C. S., Staff, R. T., Vuksanovic, V., Ahearn, T., Bracoud, L., Shamsi, K., Marek, K., Seibyl, J., Riedel, G., Storey, J. M. D. & 2 others, Harrington, C. R. & Wischik, C. M., 28 Nov 2017, In : Journal of Alzheimer's Disease. 61, 1, p. 435-457 24 p.

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32 Citations (Scopus)
18 Downloads (Pure)
2016

Absence of a Role for Phosphorylation in the Tau Pathology of Alzheimer's Disease

Lai, R. Y. K., Harrington, C. R. & Wischik, C. M., 8 Apr 2016, In : Biomolecules. 6, 2, p. 1-19 19 p., 19.

Research output: Contribution to journalArticle

Open Access
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11 Citations (Scopus)
5 Downloads (Pure)

Efficacy and safety of tau-aggregation inhibitor therapy in patients with mild or moderate Alzheimer's disease: a randomised, controlled, double-blind, parallel-arm, phase 3 trial

Gauthier, S., Feldman, H. H., Schneider, L. S., Wilcock, G. K., Frisoni, G. B., Hardlund, J. H., Moebius, H. J., Bentham, P., Kook, K. A., Wischik, D. J., Schelter, B. O., Davis, C. S., Staff, R. T., Bracoud, L., Shamsi, K., Storey, J. M. D., Harrington, C. R. & Wischik, C. M., Dec 2016, In : The Lancet. 388, 10062, p. 2873-2884 12 p.

Research output: Contribution to journalArticle

Open Access
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123 Citations (Scopus)
6 Downloads (Pure)
2015
Open Access
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47 Citations (Scopus)
8 Downloads (Pure)
64 Citations (Scopus)

Different pathways of molecular pathophysiology underlie cognitive and motor tauopathy phenotypes in transgenic models for Alzheimer’s disease and frontotemporal lobar degeneration

Melis, V., Zabke, C., Stamer, K., Magbagbeolu, M., Schwab, K., Marshall, P., Weh, R. W., Bachmann, S., Deiana, S., Moreau, P. H., Davidson, K., Harrington, K. A., Rickard, J. E., Horsley, D., Garman, R., Mazurkiewicz, M., Niewiadomska, G., Wischik, C. M., Harrington, C. R., Riedel, G. & 1 others, Theuring, F., Jun 2015, In : Cellular and Molecular Life Sciences. 72, 11, p. 2199-2222 24 p.

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Open Access
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20 Citations (Scopus)
5 Downloads (Pure)

Effects of oxidized and reduced forms of methylthioninium in two transgenic mouse tauopathy models

Melis, V., Magbagbeolu, M., Rickard, J. E., Horsley, D., Davidson, K., Harrington, K. A., Goatman, K., Goatman, E. A., Deiana, S., Close, S. P., Zabke, C., Stamer, K., Dietze, S., Schwab, K., Storey, J. M. D., Harrington, C. R., Wischik, C. M., Theuring, F. & Riedel, G., Jun 2015, In : Behavioural Pharmacology. 26, 4, p. 353-368 16 p.

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Open Access
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42 Citations (Scopus)
10 Downloads (Pure)

Tau Aggregation Inhibitor Therapy: An Exploratory Phase 2 Study in Mild or Moderate Alzheimer's Disease

Wischik, C. M., Staff, R. T., Wischik, D. J., Bentham, P., Murray, A. D., Storey, J. M. D., Kook, K. A. & Harrington, C. R., 22 Jan 2015, In : Journal of Alzheimer's Disease. 44, 2, p. 705-720 16 p.

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Open Access
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134 Citations (Scopus)
5 Downloads (Pure)

The relationship between truncation and phosphorylation at the C-terminus of tau protein in the paired helical filaments of Alzheimer's disease

Flores-Rodríguez, P., Ontiveros-Torres, M. A., Cárdenas-Aguayo, M. C., Luna-Arias, J. P., Meraz-Ríos, M. A., Viramontes-Pintos, A., Harrington, C. R., Wischik, C. M., Mena, R., Florán-Garduño, B. & Luna-Muñoz, J., 11 Feb 2015, In : Frontiers in Neuroscience. 9, 10 p., 33.

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Open Access
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22 Citations (Scopus)
7 Downloads (Pure)
2014

Tau-aggregation inhibitor therapy for Alzheimer's disease

Wischik, C. M., Harrington, C. R. & Storey, J. M. D., 15 Apr 2014, In : Biochemical Pharmacology. 88, 4, p. 529-539 11 p.

Research output: Contribution to journalArticle

Open Access
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152 Citations (Scopus)
6 Downloads (Pure)
2013

Calcyclin binding protein and Siah-1 interacting protein in Alzheimer's disease pathology: neuronal localization and possible function

Wasik, U., Schneider, G., Mietelska-Porowska, A., Mazurkiewicz, M., Fabczak, H., Weis, S., Zabke, C., Harrington, C. R., Filipek, A. & Niewiadomska, G., May 2013, In : Neurobiology of Aging. 34, 5, p. 1380-1388 9 p.

Research output: Contribution to journalArticle

17 Citations (Scopus)
2011
2 Citations (Scopus)
2009

Lewy body variant of Alzheimer's disease: selective neocortical loss of t-SNARE proteins and loss of MAP2 and alpha-synuclein in medial temporal lobe

Mukaetova-Ladinska, E. B., Xuereb, J. H., Garcia-Sierra, F., Hurt, J., Gertz, H. J., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M. A., Jakes, R., Honer, W. G., Harrington, C. R., Wischik, C. M. & CC75C Collaboration Grp, 16 Dec 2009, In : The Scientific World Journal. 9, p. 1463-1475 13 p.

Research output: Contribution to journalArticle

26 Citations (Scopus)
36 Downloads (Pure)

Methylthioninium chloride reverses cognitive deficits induced by scopolamine: comparison with rivastigmine

Deiana, S., Harrington, C. R., Wischik, C. M. & Riedel, G., Jan 2009, In : Psychopharmacology. 202, 1-3, p. 53-65 13 p.

Research output: Contribution to journalArticle

72 Citations (Scopus)
104 Downloads (Pure)
2008

Thiazin red as a neuropathological tool for the rapid diagnosis of Alzheimer's disease in tissue imprints

Luna-Munoz, J., Peralta-Ramirez, J., Chavez-Macias, L., Harrington, C. R., Wischik, C. M. & Mena, R., Nov 2008, In : Acta Neuropathologica. 116, 5, p. 507-515 9 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)
2005
4 Citations (Scopus)
2002

Loss of synaptic but not cytoskeletal proteins in the cerebellum of chronic schizophrenics

Mukaetova-Ladinska, E. B., Hurt, J., Honer, W. G., Harrington, C. R. & Wischik, C. M., 14 Jan 2002, In : Neuroscience Letters. 317, 3, p. 161-165 5 p.

Research output: Contribution to journalArticle

70 Citations (Scopus)
2001
38 Citations (Scopus)
2000

Lack of an association of estrogen receptor alpha gene polymorphisms and transcriptional activity with Alzheimer disease

Maruyama, H., Toji, H., Harrington, C. R., Sasaki, K., Izumi, Y., Ohnuma, T., Arai, H., Yasuda, M., Tanaka, C., Emson, P. C., Nakamura, S. & Kawakami, H., 2000, In : Archives of Neurology. 57, p. 236-240 5 p.

Research output: Contribution to journalArticle

Lack of an association of estrogen receptor α gene polymorphisms and transcriptional activity with Alzheimer disease

Maruyama, H., Toji, H., Harrington, C. R., Sasaki, K., Izumi, Y., Ohnuma, T., Arai, H., Yasuda, M., Tanaka, C., Emson, P. C., Nakamura, S. & Kawakami, H., 1 Jan 2000, In : Archives of Neurology. 57, 2, p. 236-240 5 p.

Research output: Contribution to journalArticle

130 Citations (Scopus)

Neuropathological findings in the very old - Results from the first 101 brains of a population-based longitudinal study of dementing disorders

Xuereb, J. H., Brayne, C., Dufouil, C., Gertz, H., Wischik, C., Harrington, C., Mukaetova-Ladinska, E., McGee, M. A., O'Sullivan, A., O'Connor, D., Paykel, E. S. & Huppert, F. A., 2000, In : Annals of the New York Academy of Sciences. 903, p. 490-496 7 p.

Research output: Contribution to journalArticle

99 Citations (Scopus)

Staging of cytoskeletal and beta-amyloid changes in human isocortex reveals biphasic synaptic protein response during progression of Alzheimer's disease

Mukaetova-Ladinska, E. B., Garcia-Siera, F., Hurt, J., Gertz, H. J., Xuereb, J. H., Hills, R., Brayne, C., Huppert, F. A., Paykel, E. S., McGee, M., Jakes, R., Honer, W. G., Harrington, C. R. & Wischik, C. M., Aug 2000, In : American Journal of Pathology. 157, 2, p. 623-636 14 p.

Research output: Contribution to journalArticle

153 Citations (Scopus)

The CCTTT polymorphism in the NOS2A gene is associated with dementia with Lewy bodies

Xu, W. M., Liu, L. Z., Emson, P., Harrington, C. R., McKeith, I. G., Perry, R. H., Morris, C. M. & Charles, I. G., 2000, In : Neuroreport. 11, p. 297-299 3 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)
1999

Association between Alzheimer's disease and the NOS3 gene

Dahiyat, M., Cumming, A., Harrington, C., Wischik, C., Xuereb, J., Corrigan, F., Breen, G., Shaw, D. & St Clair, D., 1999, In : Annals of Neurology. 46, p. 664-667 4 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)