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Research Output

A Bright Future for Fluorescence Imaging of Fungi in Living Hosts

Chapuis, A. F., Ballou, E. R. & MacCallum, D. M., 1 Jun 2019, In : Journal of Fungi. 5, 2, 9 p., 29.

Research output: Contribution to journalArticle

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Activation of the heat shock transcription factor Hsf1 is essential for the full virulence of the fungal pathogen Candida albicans

Nicholls, S., MacCallum, D. M., Kaffarnik, F. A. R., Selway, L., Peck, S. C. & Brown, A. J. P., Mar 2011, In : Fungal Genetics and Biology. 48, 3, p. 297-305 9 p.

Research output: Contribution to journalArticle

Open Access
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46 Citations (Scopus)
5 Downloads (Pure)

Adaptation of Candida albicans to environmental pH induces cell wall remodelling and enhances innate immune recognition

Sherrington, S. L., Sorsby, E., Mahtey, N., Kumwenda, P., Lenardon, M., Brown, I., Ballou, E., MacCallum, D. M. & Hall, R. A., 2017, In : PLoS Pathogens. 13, 5, e1006403.

Research output: Contribution to journalArticle

Open Access
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38 Citations (Scopus)
8 Downloads (Pure)

Amplification of TLO Mediator Subunit Genes Facilitate Filamentous Growth in Candida Spp

Liu, Z., Moran, G. P., Sullivan, D. J., MacCallum, D. M. & Myers, L. C., 31 Oct 2016, In : PLoS Genetics. 12, 10, e1006373.

Research output: Contribution to journalArticle

Open Access
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7 Citations (Scopus)
5 Downloads (Pure)

a multicenter collaborative study for the standardization of Candida albicans genotyping using a polymorphic microsatellite marker

Garcia-Hermoso, D., MacCallum, D. M., Lott, T., Sampaio, P., Buitrago Serna, M-J., Grenouillet, F., Klaassen, C. & Bretagne, S., Jul 2010, In : Journal of Clinical Microbiology. 48, 7, p. 2578-2581 4 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

A new in vitro model of host-fungus interaction

Szabo, E. K. & MacCallum, D. M., Jun 2012, In : Mycoses. 55, s4, p. 299-299 1 p.

Research output: Contribution to journalAbstract

An ex-vivo human skin model to study superficial fungal infections

Corzo-Leon, D. E., Munro, C. A. & MacCallum, D. M., 5 Jun 2019, In : Frontiers in Microbiology. 10, 17 p., 1172.

Research output: Contribution to journalArticle

Open Access
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4 Citations (Scopus)

A novel renal epithelial cell in vitro assay to assess Candida albicans virulence

Szabo, E. K. & MacCallum, D. M., 28 Feb 2014, In : Virulence. 5, 2, p. 1-11 11 p.

Research output: Contribution to journalArticle

5 Citations (Scopus)

A three day mouse model of Candida albicans infection outcome

MacCallum, D. M. & Odds, F., 2011, In : Mycoses. 54, Suppl. 2, p. 112 1 p.

Research output: Contribution to journalAbstract

Blocking two-component signalling enhances Candida albicans virulence and reveals adaptive mechanisms that counteract sustained SAPK activation

Day, A. M., Smith, D. A., Ikeh, M. A. C., Haider, M., Herrero De Dios, C. M., Brown, A. J. P., Morgan, B. A., Erwig, L. P., MacCallum, D. M. & Quinn, J., 2017, In : PLoS Pathogens. 13, 1, p. 1-27 27 p., e1006131.

Research output: Contribution to journalArticle

Open Access
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10 Citations (Scopus)
6 Downloads (Pure)

Candida Albicans: New Insights in Infection, Disease, and Treatment

MacCallum, D. M., 27 Sep 2007, New Insights in Medical Mycology. Kavanagh, K. (ed.). 1 ed. The Netherlands: Springer , p. 99-129 31 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Candida albicans Chitin Increases Arginase-1 Activity in Human Macrophages, with an Impact on Macrophage Antimicrobial Functions

Wagener, J., MacCallum, D. M., Brown, G. D., Gow, N. A. R. & Doering, T. L. (ed.), 24 Jan 2017, In : mBio. 8, 1, e01820-16.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
8 Downloads (Pure)

Candida albicans colonization and dissemination from the murine gastrointestinal tract: the influence of morphology and Th17 immunity

Vautier, S., Drummond, R. A., Chen, K., Murray, G. I., Kadosh, D., Brown, A. J. P., Gow, N. A. R., MacCallum, D. M., Kolls, J. K. & Brown, G. D., Apr 2015, In : Cellular Microbiology. 17, 4, p. 445-450 6 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
4 Downloads (Pure)

Candida albicans evades protective immunity by promoting the expansion of induced CD4(+) CD25(+) FoxP3(+) Helioslo regulatory T cells that enhance Th17 responses

Whibley, N. W., MacCallum, D. M., Vickers, M. A., Waldmann, H., Hori, S., Gow, N. A. R., Barker, R. N. & Hall, A. M., Sep 2012, In : Immunology. 137, s1, p. 206-206 1 p.

Research output: Contribution to journalAbstract

52 Citations (Scopus)

Candida albicans GRX2, encoding a putative glutaredoxi, is required for virulence in a murine model

Chaves, G., Bates, S., MacCallum, D. M. & Odds, F. C., 27 Nov 2007, In : Genetics and Molecular Research. 6, 4, p. 1051-1063 13 p.

Research output: Contribution to journalArticle

Candida albicans GRX2, encoding a putative glutaredoxin, is required for virulence in a murine model

Chaves, G. M., Bates, S., MacCallum, D. M. & Odds, F. C., 27 Dec 2007, In : Genetics and Molecular Research. 6, 4, p. 1051-1063 13 p.

Research output: Contribution to journalArticle

Open Access
35 Citations (Scopus)

Candida albicans induces the expansion of regulatory helper T cells in healthy humans

Whibley, N., Ormerod, A. D., MacCallum, D. M., Gow, N. A. R., Barker, R. N. & Hall, A. M., Dec 2011, In : Immunology. 135, Suppl. 1, p. 157 1 p., 397.

Research output: Contribution to journalAbstract

Candida albicans promotes the differentiation of induced CD4(+) CD25(+) Foxp3(+) regulatory T cells

Whibley, N., MacCallum, D. M., Vickers, M. A., Gow, N. A., Barker, R. N. & Hall, A. M., Dec 2011, In : Immunology. 135, Suppl. 1, p. 161 1 p.

Research output: Contribution to journalAbstract

Candida infections and modelling disease

MacCallum, D. M., 18 Nov 2009, Pathogenic Yeasts: The Yeast Handbook 2010. Ashbee, R. & Bignell, E. (eds.). 1 ed. Berlin: Springer-Verlag, p. 41-67 17 p. (The Yeast handbook).

Research output: Chapter in Book/Report/Conference proceedingChapter

Carnitine-dependent transport of acetyl coenzyme A in Candida albicans is essential for growth on nonfermentable carbon sources and contributes to biofilm formation

Strijbis, K., van Roermund, C. W. T., Visser, W. F., Mol, E. C., van den Burg, J., MacCallum, D. M., Odds, F. C., Paramonova, E., Krom, B. P. & Distel, B., Apr 2008, In : Eukaryotic Cell. 7, 4, p. 610-618 9 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)

CO2 acts as a signalling molecule in populations of the fungal pathogen Candida albicans

Hall, R., De Sordi, L., MacCallum, D. M., Topal, H., Eaton, R., Bloor, J. W., Robinson, G. K., Levin, L. R., Buck, J., Wang, Y., Gow, N. A. R., Steegborn, C. & Muehlschlegel, F. A., 18 Nov 2010, In : PLoS Pathogens. 6, 11, 11 p., e1001193.

Research output: Contribution to journalArticle

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75 Citations (Scopus)
4 Downloads (Pure)

Comparative transcript profiling of Candida albicans and Candida dubliniensis identifies SFL2, a C. albicans gene required for virulence in a reconstituted epithelial infection model

Spiering, M. J., Moran, G. P., Chauvel, M., MacCallum, D. M., Higgins, J., Hokamp, K., Yeomans, T., d'Enfert, C., Coleman, D. C. & Sullivan, J., Feb 2010, In : Eukaryotic Cell. 9, 2, p. 251-265 15 p.

Research output: Contribution to journalArticle

56 Citations (Scopus)

Contribution of Fdh3 and Glr1 to Glutathione Redox State, Stress Adaptation and Virulence in Candida albicans

Tillmann, A. T., Strijbis, K., Cameron, G., Radmaneshfar, E., Thiel, M., Munro, C. A., MacCallum, D. M., Distel, B., Gow, N. A. R. & Brown, A. J. P., 3 Jun 2015, In : PloS ONE. 10, 6, 24 p., e0126940.

Research output: Contribution to journalArticle

Open Access
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17 Citations (Scopus)
5 Downloads (Pure)

C-type lectin receptors and cytokines in fungal immunity

Vautier, S., Maccallum, D. M. & Brown, G. D., Apr 2012, In : Cytokine. 58, 1, p. 89-99 10 p.

Research output: Contribution to journalArticle

64 Citations (Scopus)

Cytokine Measurement Using Cytometric Bead Arrays

Castillo-Barahona, L. C. & MacCallum, D. M., 2012, Host-Fungus Interactions: Methods and Protocols. Brand, A. C. & MacCallum, D. M. (eds.). Humana Press, Vol. 845. p. 425-434 10 p. (Methods in Molecular Biology; vol. 845, no. 6).

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)

Dectin-1 is not required for controlling Candida albicans colonisation of the gastrointestinal tract

Vautier, S., Drummond, R. A., Redelinghuys, P., Murray, G. I., Maccallum, D. M. & Brown, G. D., Dec 2012, In : Infection and Immunity. 80, 12, p. 4216-4222 7 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Different consequences of ACE2 and SWI5 gene disruptions for virulence of pathogenic and nonpathogenic yeasts

MacCallum, D. M., Findon, H., Kenny, C. C., Butler, G., Haynes, K. & Odds, F. C., 1 Sep 2006, In : Infection and Immunity. 74, 9, p. 5244-5248 5 p.

Research output: Contribution to journalArticle

29 Citations (Scopus)

Differential adaptation of Candida albicans in vivo modulates immune recognition by dectin-1

Marakalala, M. J., Vautier, S., Potrykus, J., Walker, L. A., Shepardson, K. M., Hopke, A., Mora-Montes, H. M., Lee, K., Kerrigan, A., Netea, M. G., Murray, G. I., Maccallum, D. M., Wheeler, R., Munro, C. A., Gow, N. A. R., Cramer, R. A., Brown, A. J. P. & Brown, G. D., 2013, In : PLoS Pathogens. 9, 4, 12 p., e1003315.

Research output: Contribution to journalArticle

Open Access
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109 Citations (Scopus)
4 Downloads (Pure)
11 Citations (Scopus)

Differential regulation of kidney and spleen cytokine responses in mice infected with a Candida albicans mannosylation mutant

Castillo, L. C., Maccallum, D. M., Brown, A. J. P., Gow, N. A. R. & Odds, F. C., Oct 2011, In : Mycoses. 54, Suppl. 2, p. 114 1 p.

Research output: Contribution to journalAbstract

Differential regulation of the transcriptional repressor NRG1 accounts for altered host-cell interactions in Candida albicans and Candida dubliniensis

Moran, G. P., MacCallum, D. M., Spiering, M. J., Coleman, D. C. & Sullivan, D. J., Nov 2007, In : Molecular Microbiology. 66, 4, p. 915-929 15 p.

Research output: Contribution to journalArticle

37 Citations (Scopus)

Echinocandin resistance due to simultaneous FKS mutation and increased cell wall chitin in a Candida albicans bloodstream isolate following brief exposure to caspofungin

Imtiaz, T., Lee, K. K., Munro, C. A., Maccallum, D. M., Shankland, G. S., Johnson, E. M., Macgregor, M. S. & Bal, A. M., Sep 2012, In : Journal of Medical Microbiology. 61, 9, p. 1330-1334 5 p.

Research output: Contribution to journalArticle

15 Citations (Scopus)
211 Citations (Scopus)

Efficacy of caspofungin and voriconazole combinations in experimental aspergillosis

MacCallum, D. M., Whyte, J. A. & Odds, F. C., 2005, In : Antimicrobial Agents and Chemotherapy. 49, p. 3697-3701 5 p.

Research output: Contribution to journalArticle

59 Citations (Scopus)
4 Citations (Scopus)

Elevated catalase expression in a fungal pathogen is a double-edged sword of iron

Pradhan, A., Herrero De Dios, C., Belmonte, R., Budge, S., Lopez Garcia, A., Kolmogorova, A., LEE, K. K., Martin, B. D., Ribeiro, A., Bebes, A., Yuecel, R., Gow, N. A. R., Munro, C. A., MacCallum, D. M., Quinn, J. & Brown, A. J. P., 22 May 2017, In : PLoS Pathogens. 13, 5, p. 1-25 25 p., 1006405.

Research output: Contribution to journalArticle

Open Access
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12 Citations (Scopus)
5 Downloads (Pure)

Elevated Cell Wall Chitin in Candida albicans Confers Echinocandin Resistance In Vivo

Lee, K. K., Maccallum, D. M., Jacobsen, M. D., Walker, L. A., Odds, F. C., Gow, N. A. R. & Munro, C. A., Jan 2012, In : Antimicrobial Agents and Chemotherapy. 56, 1, p. 208-217 10 p.

Research output: Contribution to journalArticle

108 Citations (Scopus)
6 Citations (Scopus)

Erratum to: Single human B cell-derived monoclonal anti-Candida antibodies enhance phagocytosis and protect against disseminated candidiasis (Nature Communications, (2018), 9, 1, (5288), 10.1038/s41467-018-07738-1)

Rudkin, F. M., Raziunaite, I., Workman, H., Essono, S., Belmonte, R., MacCallum, D. M., Johnson, E. M., Silva, L., Palma, A. S., Feizi, T., Jensen, A., Erwig, L. P. & Gow, N. A. R., 18 Jan 2019, In : Nature Communications. 10, 394.

Research output: Contribution to journalComment/debate

Open Access

Expansion of Foxp3+ T-cell populations by Candida albicans enhances both Th17-cell responses and fungal dissemination after intravenous challenge

Whibley, N., Maccallum, D. M., Vickers, M. A., Zafreen, S., Waldmann, H., Hori, S., Gaffen, S. L., Gow, N. A. R., Barker, R. N. & Hall, A. M., Apr 2014, In : European Journal of Immunology. 44, 4, p. 1069-1083 15 p.

Research output: Contribution to journalArticle

Open Access
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26 Citations (Scopus)
6 Downloads (Pure)

Functional analysis of the phospholipase C gene CaPLC1 and two unusual phospholipase C genes, CaPLC2 and CaPLC3, of Candida albicans

Kunze, D., Melzer, I., Bennett, D., Sanglard, D., MacCallum, D. M., Nörskau, J., Coleman, D. C., Odds, F. C., Schäfer, W. & Hube, B., 1 Oct 2005, In : Microbiology . 151, 10, p. 3381-94 14 p.

Research output: Contribution to journalArticle

21 Citations (Scopus)

Functional specialization and differential regulation of short-chain carboxylic acid transporters in the pathogen Candida albicans

Vieira, N., Casal, M., Johansson, B., MacCallum, D. M., Brown, A. J. P. & Paiva, S., Mar 2010, In : Molecular Microbiology. 75, 6, p. 1337-1354 18 p.

Research output: Contribution to journalArticle

Open Access
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31 Citations (Scopus)
3 Downloads (Pure)

Fungal chitin dampens inflammation through IL-10 induction mediated by NOD2 and TLR9 activation

Wagener, J., Malireddi, R. K. S., Lenardon, M. D., Köberle, M., Vautier, S., Maccallum, D. M., Biedermann, T., Schaller, M., Netea, M. G., Kanneganti, T-D., Brown, G. D., Brown, A. J. P. & Gow, N. A. R., 10 Apr 2014, In : PLoS Pathogens. 10, 4, 15 p., e1004050.

Research output: Contribution to journalArticle

Open Access
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123 Citations (Scopus)
3 Downloads (Pure)

Fungal iron availability during deep seated candidiasis is defined by a complex interplay involving systemic and local events

Potrykus, J., Stead, D., Maccallum, D. M., Urgast, D. S., Raab, A., van Rooijen, N., Feldmann, J. & Brown, A. J. P., 17 Oct 2013, In : PLoS Pathogens. 9, 10, 12 p., e1003676.

Research output: Contribution to journalArticle

Open Access
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32 Citations (Scopus)
5 Downloads (Pure)

Genetic dissection of azole resistance mechanisms in Candida albicansand their validation in a mouse model of disseminated infection

MacCallum, D. M., Coste, A., Ischer, F., Jacobsen, M. D., Odds, F. C. & Sanglard, D., Apr 2010, In : Antimicrobial Agents and Chemotherapy. 54, 4, p. 1476-1483 8 p.

Research output: Contribution to journalArticle

82 Citations (Scopus)

Genome-wide analysis of Candida albicans gene expression patterns during infection of the mammalian kidney

Walker, L. A., MacCallum, D. M., Bertram, G., Gow, N. A. R., Odds, F. C. & Brown, A. J. P., Feb 2009, In : Fungal Genetics and Biology. 46, 2, p. 210-219 10 p.

Research output: Contribution to journalArticle

Open Access
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59 Citations (Scopus)
52 Downloads (Pure)

Genome-wide gene expression profiling and a forward genetic screen show that differential expression of the sodium ion transporter Ena21 contributes to the differential tolerance of Candida albicans and Candida dubliniensis to osmotic stress

Enjalbert, B., Moran, G. P., Vaughan, C., Yeomans, T., MacCallum, D. M., Quinn, J., Coleman, D. C., Brown, A. J. P. & Sullivan, D. J., Apr 2009, In : Molecular Microbiology. 72, 1, p. 216-228 13 p.

Research output: Contribution to journalArticle

28 Citations (Scopus)

GFP as a quantitative reporter of gene regulation in Candida albicans

Barelle, C., Manson, C. L., MacCallum, D. M., Odds, F. C., Gow, N. A. R. & Brown, A. J. P., Mar 2004, In : Yeast. 21, 4, p. 333-340 8 p.

Research output: Contribution to journalArticle

90 Citations (Scopus)

Glycosylphosphatidylinositol-anchored proteases of Candida albicans target proteins necessary for both cellular processes and host-pathogen interactions

Albrecht, A., Felk, A., Pichova, I., Naglik, J. R., Schaller, M., de Groot, P., MacCallum, D. M., Odds, F. C., Schäfer, W., Klis, F., Monod, M. & Hube, B., 13 Jan 2006, In : The Journal of Biological Chemistry. 281, 2, p. 688-94 7 p.

Research output: Contribution to journalArticle

180 Citations (Scopus)

Granulocytes govern the transcriptional response, morphology and proliferation of Candida albicans in human blood

Fradin, C., De Groot, P., MacCallum, D. M., Schaller, M., Klis, F., Odds, F. C. & Hube, B., 1 Apr 2005, In : Molecular Microbiology. 56, 2, p. 397-415 19 p.

Research output: Contribution to journalArticle

302 Citations (Scopus)