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Thomas Baddeley

Dr

    • AB24 3UE

    • 121 Citations
    20012019
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    • 13 Similar Profiles
    Phenylhydrazines Chemical Compounds
    Alzheimer Disease Medicine & Life Sciences
    Hydrogen bonds Chemical Compounds
    Synucleins Medicine & Life Sciences
    Sharks Medicine & Life Sciences
    Hydrazones Chemical Compounds
    tau Proteins Chemical Compounds
    Trehalose Medicine & Life Sciences

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    Research Output 2001 2019

    • 121 Citations
    • 23 Article
    • 2 Patent
    Open Access
    File
    Computational chemistry
    computational chemistry
    hydrazides
    Surface analysis
    Benzene
    1 Citation (Scopus)

    Synthesis, potent anti-TB activity against M. tuberculosis ATTC 27294, crystal structures and complex formation of selected 2-arylidenehydrazinylbenzothiazole derivatives

    Pinheiro, A. C., de Souza, M. V. N., Lourenco, M. C. S., da Costa, C. F., Baddeley, T. C., Low, J. N., Wardell, S. M. S. V. & Wardell, J. L., 15 Feb 2019, In : Journal of Molecular Structure. 1178, p. 655-668 14 p.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)
    11 Downloads (Pure)
    Open Access
    File
    Synucleins
    Transgenic Mice
    Proteins
    Parkinson Disease
    Endopeptidase K
    Hydrogen Bonding
    Hydrates
    Hydrogen bonds
    Crystal structure
    Steroids
    1 Citation (Scopus)
    7 Downloads (Pure)

    Cysteine-independent inhibition of Alzheimer's disease-like paired helical filament assembly by leuco-methylthioninium (LMT)

    Al-Hilaly, Y. K., Pollack, S. J., Rickard, J. E., Simpson, M., Raulin, A-C., Baddeley, T., Schellenberger, P., Storey, J. M. D., Harrington, C. R., Wischik, C. M. & Serpell, L. C., 19 Oct 2018, In : Journal of Molecular Biology. 430, 21, p. 4119-4131 13 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    Cysteine
    Alzheimer Disease
    Tauopathies
    tau Proteins
    Neurofibrillary Tangles

    Impacts

    Discovery and commercialisation of an entirely new drug for the treatment of Alzheimer's disease

    Claude Michel Wischik (Participant), Charles Robert Harrington (Participant), John Mervyn David Storey (Participant), Janet Elizabeth Rickard (Participant), David Horsley (Participant), Thomas Baddeley (Participant), Steven John Kemp (Participant), James Peter Sinclair (Participant), Claudia Zabke (Participant), F. Theuring (Participant), F Stamer (Participant), C Marshall (Participant)

    Impact: Quality of life Impacts, Economic Impacts