Roger Pertwee

Professor

    • 26918 Citations
    1970 …2020

    Research output per year

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    Research Output

    2020

    Anticancer effects of n-3 EPA and DHA and their endocannabinoid derivatives on breast cancer cell growth and invasion

    Brown, I., Lee, J., Sneddon, A. A., Cascio, M. G., Pertwee, R. G., Wahle, K. W. J., Rotondo, D. & Heys, S. D., May 2020, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 156, 10 p., 102024.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)
    Open Access
    File
    3 Downloads (Pure)
    2019

    A synthetic analogue of cannabidiolic acid that acts like a positive allosteric modulator at 5-HT1A receptors

    Alcina, A. G., Stevenson, L. A., Haj, C., Smoum, R., Mechoulam, R., Hislop, J. N. & Pertwee, R. G., Aug 2019, In : British Journal of Pharmacology. 176, 16, p. 3011-3012 2 p., OC011.

    Research output: Contribution to journalAbstract

    Open Access
    Open Access
    File
    4 Citations (Scopus)
    4 Downloads (Pure)

    Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury

    Georgieva, M., Wei, Y., Dumitrascuta, M., Pertwee, R., Finnerup, N. B. & Huang, W., Dec 2019, In : Pain. 160, 12, p. 2724-2742 19 p.

    Research output: Contribution to journalArticle

    1 Citation (Scopus)

    Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

    Gado, F., Di Cesare Mannelli, L., Lucarini, E., Bertini, S., Cappelli, E., Digiacomo, M., Stevenson, L. A., Macchia, M., Tuccinardi, T., Ghelardini, C., Pertwee, R. G. & Manera, C., 10 Jan 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 276-287 12 p.

    Research output: Contribution to journalArticle

    9 Citations (Scopus)
    2018

    Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

    Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A. & Hohmann, A. G., 15 Nov 2018, In : Biological Psychiatry. 84, 10, p. 722-733 12 p.

    Research output: Contribution to journalArticle

    29 Citations (Scopus)
    2017

    Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

    Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E. & Zanda, M., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2086-2096 11 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    3 Citations (Scopus)
    8 Downloads (Pure)

    The pharmacology and therapeutic potential of plant cannabinoids

    Cascio, M. G., Pertwee, R. G. & Marini, P., 2017, Cannabis sativa L. - Botany and Biotechnology. Chandra, S., Lata, H. & ElSohly, M. A. (eds.). Springer, Biomedicine & Life Sciences, p. 207-225 19 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    6 Citations (Scopus)
    2016

    Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

    Colizzi, M., McGuire, P., Pertwee, R. G. & Bhattacharyya, S., May 2016, In : Neuroscience & Biobehavioral Reviews. 64, p. 359-381 23 p.

    Research output: Contribution to journalLiterature review

    62 Citations (Scopus)

    Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

    Laprairie, R. B., Kulkarni, A. R., Kulkarni, P. M., Hurst, D. P., Lynch, D., Reggio, P. H., Janero, D. R., Pertwee, R. G., Stevenson, L. A., Kelly, M. E. M., Denovan-Wright, E. M. & Thakur, G. A., 15 Jun 2016, In : ACS Chemical Neuroscience. 7, 6, p. 776-798 23 p.

    Research output: Contribution to journalArticle

    22 Citations (Scopus)

    Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

    Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G. & Thakur, G. A., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 44-60 17 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    34 Citations (Scopus)
    6 Downloads (Pure)

    The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

    Marini, P., Cascio, M. G. & Pertwee, R. G., 2016, Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). New York: Springer Science+Business Media, p. 85-93 9 p. (Methods in Molecular Biology; vol. 1412).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    3 Citations (Scopus)

    The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

    Cascio, M. G., Marini, P. & Pertwee, R. G., 1 Jun 2016, Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). Springer Science+Business Media, Vol. 1412. p. 57-63 7 p. (Methods in Molecular Biology; vol. 1412).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    2015

    Are cannabidiol and Delta(9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

    McPartland, J. M., Duncan, M., Di Marzo, V. & Pertwee, R. G., Feb 2015, In : British Journal of Pharmacology. 172, 3, p. 737-753 17 p.

    Research output: Contribution to journalLiterature review

    199 Citations (Scopus)

    CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

    Smoum, R., Baraghithy, S., Chourasia, M., Breuer, A., Mussai, N., Attar-Namdar, M., Kogan, N. M., Raphael, B., Bolognini, D., Cascio, M. G., Marini, P., Pertwee, R. G., Shurki, A., Mechoulam, R. & Bab, I., 14 Jul 2015, In : PNAS. 112, 28, p. 8774-8779 6 p.

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Endocannabinoids

    Pertwee, R. G., 2015, 1 ed. Springer . 30 p. (Handbook of Experimental Pharmacology; vol. 231)

    Research output: Book/ReportBook

    Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

    Mounsey, R. B., Mustafa, S., Robinson, L., Ross, R. A., Riedel, G., Pertwee, R. G. & Teismann, P., Nov 2015, In : Experimental Neurology. 273, p. 36-44 9 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    28 Citations (Scopus)
    5 Downloads (Pure)

    Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

    Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In : Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

    Research output: Contribution to journalArticle

    10 Citations (Scopus)

    The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

    Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D. & Pertwee, R. G., Mar 2015, In : British Journal of Pharmacology. 172, 5, p. 1305-1318 14 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    14 Citations (Scopus)
    5 Downloads (Pure)

    Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands

    Zanato, C., Cascio, M. G., Lazzari, P., Pertwee, R., Testa, A. & Zanda, M., Mar 2015, In : Synthesis. 47, 6, p. 817-826 10 p.

    Research output: Contribution to journalArticle

    Open Access
    File
    6 Citations (Scopus)
    16 Downloads (Pure)
    2014

    Early phytocannabinoid chemistry to endocannabinoids and beyond

    Mechoulam, R., Hanus, L. O., Pertwee, R. & Howlett, A. C., Nov 2014, In : Nature reviews neuroscience. 15, 11, p. 757-764 8 p.

    Research output: Contribution to journalArticle

    124 Citations (Scopus)
    48 Citations (Scopus)

    Handbook of Cannabis

    Pertwee, R. G. (ed.), 2014, 1 ed. Oxford: OXFORD UNIV PRESS.

    Research output: Book/ReportBook

    Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

    Romano, B., Borrelli, F., Pagano, E., Cascio, M. G., Pertwee, R. G. & Izzo, A. A., 15 Apr 2014, In : Phytomedicine. 21, 5, p. 631-639 9 p.

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

    Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

    Research output: Contribution to journalArticle

    42 Citations (Scopus)

    Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

    Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R. & Zanda, M., Nov 2014, In : Journal of Fluorine Chemistry. 167, p. 184-191 8 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

    Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G. & Di Marzo, V., 1 Sep 2014, In : Behavioral and Brain Sciences. 22, 17, p. 4770-4783 14 p.

    Research output: Contribution to journalArticle

    6 Citations (Scopus)
    1 Downloads (Pure)

    The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act trough 5HT1A receptors to produce anti-psychotic effects

    Cascio, M. G., Zamberletti, E., Marini, P., Pertwee, R. G. & Parolaro, D., 29 Jun 2014.

    Research output: Contribution to conferencePoster

    2013

    Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

    Fernandez-Ruiz, J., Sagredo, O., Ruth Pazos, M., Garcia, C., Pertwee, R., Mechoulam, R. & Martinez-Orgado, J., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 323-333 11 p.

    Research output: Contribution to journalArticle

    143 Citations (Scopus)

    Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation

    Bolognini, D., Rock, EM., Cluny, NL., Cascio, MG., Limebeer, CL., Duncan, M., Stott, CG., Javid, FA., Parker, LA. & Pertwee, RG., Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1456-1470 15 p.

    Research output: Contribution to journalArticle

    69 Citations (Scopus)

    Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

    Hill, T. D. M., Cascio, M-G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., Whalley, B. J. & Hill, A. J., Oct 2013, In : British Journal of Pharmacology. 170, 3, p. 679-692 14 p.

    Research output: Contribution to journalArticle

    96 Citations (Scopus)

    Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

    Brown, I., Cascio, M. G., Rotondo, D., Pertwee, R. G., Heys, S. D. & Wahle, K. W. J., Jan 2013, In : Progress in Lipid Research. 52, 1, p. 80-109 30 p.

    Research output: Contribution to journalArticle

    62 Citations (Scopus)

    CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

    Baillie, G. L., Horswill, J. G., Anavi-Goffer, S., Reggio, P. H., Bolognini, D., Abood, M. E., McAllister, S., Strange, P. G., Stephens, G. J., Pertwee, R. G. & Ross, R. A., Feb 2013, In : Molecular Pharmacology. 83, 2, p. 322-338 17 p.

    Research output: Contribution to journalArticle

    77 Citations (Scopus)

    Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

    Marini, P., Cascio, M. G., King, A., Pertwee, R. G. & Ross, R. A., Jun 2013, In : British Journal of Pharmacology. 169, 4, p. 887-899 13 p.

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

    Espejo-Porras, F., Fernandez-Ruiz, J., Pertwee, R. G., Mechoulam, R. & Garcia, C., Dec 2013, In : Neuropharmacology. 75, p. 155-163 9 p.

    Research output: Contribution to journalArticle

    25 Citations (Scopus)

    The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

    Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M. G., Pertwee, R. G., Coppola, D., Vassallo, L., Orlando, P., Di Marzo, V. & Izzo, A. A., May 2013, In : British Journal of Pharmacology. 169, 1, p. 213-229 16 p.

    Research output: Contribution to journalArticle

    76 Citations (Scopus)
    2012

    AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor

    Bolognini, D., Cascio, M. G., Parolaro, D. & Pertwee, R. G., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2561-2574 14 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)

    Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

    Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi-Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G. & Parker, L. A., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2620-2634 15 p.

    Research output: Contribution to journalArticle

    103 Citations (Scopus)

    Delta(8)-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

    Batkai, S., Mukhopadhyay, P., Horvath, B., Rajesh, M., Gao, R. Y., Mahadevan, A., Amere, M., Battista, N., Lichtman, A. H., Gauson, L. A., Maccarrone, M., Pertwee, R. G. & Pacher, P., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2450-2461 12 p.

    Research output: Contribution to journalArticle

    28 Citations (Scopus)

    Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

    Pasquini, S., De Rosa, M., Ligresti, A., Mugnaini, C., Brizzi, A., Caradonna, N. P., Cascio, M. G., Bolognini, D., Pertwee, R. G., Di Marzo, V. & Corelli, F., Dec 2012, In : European Journal of Medicinal Chemistry. 58, p. 30-43 14 p.

    Research output: Contribution to journalArticle

    14 Citations (Scopus)

    Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach

    Mugnaini, C., Nocerino, S., Pedani, V., Pasquini, S., Tafi, A., De Chiaro, M., Bellucci, L., Valoti, M., Guida, F., Luongo, L., Dragoni, S., Ligresti, A., Rosenberg, A., Bolognini, D., Cascio, M. G., Pertwee, R. G., Moaddel, R., Maione, S., Di Marzo, V. & Corelli, F., May 2012, In : ChemMedChem. 7, 5, p. 920-934 15 p.

    Research output: Contribution to journalArticle

    23 Citations (Scopus)

    Manipulation of the endocannabinoid system to provide a protective benefit in the MPTP-mouse model

    Mounsey, R. B., Mustafa, S., Strachan, L., Riedel, G., Ross, R., Pertwee, R. G. & Teismann, P., Aug 2012.

    Research output: Contribution to conferencePoster

    Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

    Anavi-Goffer, S., Baillie, G., Irving, A., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A., 2 Jan 2012, In : The Journal of Biological Chemistry. 287, 1, p. 91-104 15 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors

    Valdeolivas, S., Satta, V., Pertwee, R. G., Fernandez-Ruiz, J. & Sagredo, O., 9 Feb 2012, In : ACS Chemical Neuroscience. 3, 5, p. 400-406 7 p.

    Research output: Contribution to journalArticle

    64 Citations (Scopus)

    The endocannabinoid 2-AG provides neuroprotection in the MPTP model of Parkinson's disease

    Mounsey, R. B., Mustafa, S., Ross, R., Pertwee, R. G. & Teismann, P., 2012.

    Research output: Contribution to conferenceOther

    2011

    N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

    Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G. & Abdelrahman, M. H., 28 Feb 2011, IPC No. WO2012117216, Patent No. WO2012117216

    Research output: Patent

    Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

    Brown, I., Wahle, K. W., Cascio, M. G., Smoum, R., Mechoulam, R., Pertwee, R. G. & Heys, S. D., Dec 2011, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, 6, p. 305-310 6 p.

    Research output: Contribution to journalArticle

    28 Citations (Scopus)