• 24800 Citations
1970 …2019
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Research Output 1970 2019

2019

A synthetic analogue of cannabidiolic acid that acts like a positive allosteric modulator at 5-HT1A receptors

Alcina, A. G., Stevenson, L. A., Haj, C., Smoum, R., Mechoulam, R., Hislop, J. N. & Pertwee, R. G., Aug 2019, In : British Journal of Pharmacology. 176, 16, p. 3011-3012 2 p., OC011.

Research output: Contribution to journalAbstract

Open Access

Fatty acid suppression of glial activation prevents central neuropathic pain after spinal cord injury

Georgieva, M., Wei, Y., Dumitrascuta, M., Pertwee, R., Finnerup, N. B. & Huang, W., 29 Jul 2019, In : Pain.

Research output: Contribution to journalArticle

Neuralgia
Spinal Cord Injuries
Neuroglia
Docosahexaenoic Acids
Fatty Acids
4 Citations (Scopus)

Identification of the First Synthetic Allosteric Modulator of the CB2 Receptors and Evidence of Its Efficacy for Neuropathic Pain Relief

Gado, F., Di Cesare Mannelli, L., Lucarini, E., Bertini, S., Cappelli, E., Digiacomo, M., Stevenson, L. A., Macchia, M., Tuccinardi, T., Ghelardini, C., Pertwee, R. G. & Manera, C., 10 Jan 2019, In : Journal of Medicinal Chemistry. 62, 1, p. 276-287 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Cannabinoid Receptors
Neuralgia
Allosteric Site
Ligands
2018
14 Citations (Scopus)

Positive Allosteric Modulation of Cannabinoid Receptor Type 1 Suppresses Pathological Pain Without Producing Tolerance or Dependence

Slivicki, R. A., Xu, Z., Kulkarni, P. M., Pertwee, R. G., Mackie, K., Thakur, G. A. & Hohmann, A. G., 15 Nov 2018, In : Biological Psychiatry. 84, 10, p. 722-733 12 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Cannabinoid Receptors
Monoacylglycerol Lipases
Paclitaxel
Cannabinoid Receptor Agonists
2017
2 Citations (Scopus)
7 Downloads (Pure)

Synthesis, radio-synthesis and in vitro evaluation of terminally fluorinated derivatives of HU-210 and HU-211 as novel candidate PET tracers

Zanato, C., Pelagalli, A., Marwick, K. F. M., Piras, M., Dall'Angelo, S., Spinaci, A., Pertwee, R. G., Wyllie, D. J. A., Hardingham, G. E. & Zanda, M., 2017, In : Organic & Biomolecular Chemistry. 15, 9, p. 2086-2096 11 p.

Research output: Contribution to journalArticle

Open Access
File
Radio
tracers
Derivatives
aspartates
evaluation
2 Citations (Scopus)

The pharmacology and therapeutic potential of plant cannabinoids

Cascio, M. G., Pertwee, R. G. & Marini, P., 2017, Cannabis sativa L. - Botany and Biotechnology. Chandra, S., Lata, H. & ElSohly, M. A. (eds.). Springer, Biomedicine & Life Sciences, p. 207-225 19 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cannabinoids
Pharmacology
Dronabinol
Therapeutics
Cannabinoid Receptors
2016
43 Citations (Scopus)

Effect of cannabis on glutamate signalling in the brain: A systematic review of human and animal evidence

Colizzi, M., McGuire, P., Pertwee, R. G. & Bhattacharyya, S., May 2016, In : Neuroscience & Biobehavioral Reviews. 64, p. 359-381 23 p.

Research output: Contribution to journalLiterature review

19 Citations (Scopus)

Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe

Laprairie, R. B., Kulkarni, A. R., Kulkarni, P. M., Hurst, D. P., Lynch, D., Reggio, P. H., Janero, D. R., Pertwee, R. G., Stevenson, L. A., Kelly, M. E. M., Denovan-Wright, E. M. & Thakur, G. A., 15 Jun 2016, In : ACS Chemical Neuroscience. 7, 6, p. 776-798 23 p.

Research output: Contribution to journalArticle

30 Citations (Scopus)
5 Downloads (Pure)

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s)

Kulkarni, P. M., Kulkarni, A. R., Korde, A., Tichkule, R. B., Laprairie, R. B., Denovan-Wright, E. M., Zhou, H., Janero, D. R., Zvonok, N., Makriyannis, A., Cascio, M. G., Pertwee, R. G. & Thakur, G. A., 14 Jan 2016, In : Journal of Medicinal Chemistry. 59, 1, p. 44-60 17 p.

Research output: Contribution to journalArticle

Open Access
File
3 Citations (Scopus)

The Cyclic AMP Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

Marini, P., Cascio, M. G. & Pertwee, R. G., 2016, Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). New York: Springer Science+Business Media, p. 85-93 9 p. (Methods in Molecular Biology; vol. 1412).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cannabinoid Receptor CB2
Cyclic AMP
G-Protein-Coupled Receptors
Cricetulus
Pharmacology

The Displacement Binding Assay Using Human Cannabinoid CB2 Receptor-Transfected Cells

Cascio, M. G., Marini, P. & Pertwee, R. G., 1 Jun 2016, Endocannabinoid Signaling: Methods and Protocols. Maccarrone, M. (ed.). Springer Science+Business Media, Vol. 1412. p. 57-63 7 p. (Methods in Molecular Biology; vol. 1412).

Research output: Chapter in Book/Report/Conference proceedingChapter

Cannabinoid Receptor CB2
Phytochemicals
Cricetulus
2015
153 Citations (Scopus)

Are cannabidiol and Delta(9)-tetrahydrocannabivarin negative modulators of the endocannabinoid system? A systematic review

McPartland, J. M., Duncan, M., Di Marzo, V. & Pertwee, R. G., Feb 2015, In : British Journal of Pharmacology. 172, 3, p. 737-753 17 p.

Research output: Contribution to journalLiterature review

21 Citations (Scopus)

CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potency

Smoum, R., Baraghithy, S., Chourasia, M., Breuer, A., Mussai, N., Attar-Namdar, M., Kogan, N. M., Raphael, B., Bolognini, D., Cascio, M. G., Marini, P., Pertwee, R. G., Shurki, A., Mechoulam, R. & Bab, I., 14 Jul 2015, In : PNAS. 112, 28, p. 8774-8779 6 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor Agonists
Cannabinoid Receptor CB2
Cannabinoid Receptor CB1
HU 308
Ligands

Endocannabinoids

Pertwee, R. G., 2015, 1 ed. Springer . 30 p. (Handbook of Experimental Pharmacology; vol. 231)

Research output: Book/ReportBook

19 Citations (Scopus)
4 Downloads (Pure)

Increasing levels of the endocannabinoid 2-AG is neuroprotective in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson's disease

Mounsey, R. B., Mustafa, S., Robinson, L., Ross, R. A., Riedel, G., Pertwee, R. G. & Teismann, P., Nov 2015, In : Experimental Neurology. 273, p. 36-44 9 p.

Research output: Contribution to journalArticle

Open Access
File
8 Citations (Scopus)

Modulation of food consumption and sleep-wake cycle in mice by the neutral CB1 antagonist ABD459

Goonawardena, A. V., Plano, A., Robinson, L., Ross, R., Greig, I., Pertwee, R. G., Hampson, R. E., Platt, B. & Riedel, G., Apr 2015, In : Behavioural Pharmacology. 26, 3, p. 289-303 15 p.

Research output: Contribution to journalArticle

Sleep
Food
Endocannabinoids
REM Sleep
Arousal
9 Citations (Scopus)
4 Downloads (Pure)

The phytocannabinoid, Δ(9) -tetrahydrocannabivarin, can act through 5-HT1 A receptors to produce antipsychotic effects

Cascio, M. G., Zamberletti, E., Marini, P., Parolaro, D. & Pertwee, R. G., Mar 2015, In : British Journal of Pharmacology. 172, 5, p. 1305-1318 14 p.

Research output: Contribution to journalArticle

Open Access
File
Serotonin 5-HT1 Receptors
Receptor, Serotonin, 5-HT1A
8-Hydroxy-2-(di-n-propylamino)tetralin
Antipsychotic Agents
Membranes
6 Citations (Scopus)
12 Downloads (Pure)

Tricyclic fused pyrazoles with a 'Click' 1,2,3-triazole substituent in position 3 are nanomolar CB1 receptor ligands

Zanato, C., Cascio, M. G., Lazzari, P., Pertwee, R., Testa, A. & Zanda, M., Mar 2015, In : Synthesis. 47, 6, p. 817-826 10 p.

Research output: Contribution to journalArticle

Open Access
File
Pyrazoles
Cannabinoid Receptor CB1
rimonabant
Triazoles
Chlorine
2014
105 Citations (Scopus)

Early phytocannabinoid chemistry to endocannabinoids and beyond

Mechoulam, R., Hanus, L. O., Pertwee, R. & Howlett, A. C., Nov 2014, In : Nature reviews neuroscience. 15, 11, p. 757-764 8 p.

Research output: Contribution to journalArticle

41 Citations (Scopus)

Handbook of Cannabis

Pertwee, R. G. (ed.), 2014, 1 ed. Oxford: OXFORD UNIV PRESS.

Research output: Book/ReportBook

drug
medicine
self-medication
regulation
history
38 Citations (Scopus)

Inhibition of colon carcinogenesis by a standardized Cannabis sativa extract with high content of cannabidiol

Romano, B., Borrelli, F., Pagano, E., Cascio, M. G., Pertwee, R. G. & Izzo, A. A., 15 Apr 2014, In : Phytomedicine. 21, 5, p. 631-639 9 p.

Research output: Contribution to journalArticle

33 Citations (Scopus)

In-vivo pharmacological evaluation of the CB1-receptor allosteric modulator Org-27569

Gamage, T. F., Ignatowska-Jankowska, B. M., Wiley, J. L., Abdelrahman, M., Trembleau, L., Greig, I. R., Thakur, G. A., Tichkule, R., Poklis, J., Ross, R. A., Pertwee, R. G. & Lichtman, A. H., Apr 2014, In : Behavioural Pharmacology. 25, 2, p. 182-185 4 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Pharmacology
rimonabant
Dronabinol
Appetite Depressants
3 Citations (Scopus)

Pyrazoles with a "click" 4-[N-(4-fluorobutyl)-1,2,3-triazole] substituent in position 3 are nanomolar CB1 receptor ligands

Distinto, R., Zanato, C., Montanari, S., Cascio, M. G., Lazzari, P., Pertwee, R. & Zanda, M., Nov 2014, In : Journal of Fluorine Chemistry. 167, p. 184-191 8 p.

Research output: Contribution to journalArticle

rimonabant
Pyrazoles
Cannabinoid Receptor CB1
Triazoles
ligand
6 Citations (Scopus)
1 Downloads (Pure)

Structure-affinity relationships and pharmacological characterization of new alkyl-resorcinol cannabinoid receptor ligands: Identification of a dual cannabinoid receptor/TRPA1 channel agonist

Brizzi, A., Aiello, F., Marini, P., Cascio, M. G., Corelli, F., Brizzi, V., De Petrocellis, L., Ligresti, A., Luongo, L., Lamponi, S., Maione, S., Pertwee, R. G. & Di Marzo, V., 1 Sep 2014, In : Behavioral and Brain Sciences. 22, 17, p. 4770-4783 14 p.

Research output: Contribution to journalArticle

Monoacylglycerol Lipases
Ankyrins
Cannabinoid Receptors
Pharmacology
Cannabinoid Receptor CB2

The phytocannabinoid, Δ9-tetrahydrocannabivarin, can act trough 5HT1A receptors to produce anti-psychotic effects

Cascio, M. G., Zamberletti, E., Marini, P., Pertwee, R. G. & Parolaro, D., 29 Jun 2014.

Research output: Contribution to conferencePoster

2013
116 Citations (Scopus)

Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

Fernandez-Ruiz, J., Sagredo, O., Ruth Pazos, M., Garcia, C., Pertwee, R., Mechoulam, R. & Martinez-Orgado, J., Feb 2013, In : British Journal of Clinical Pharmacology. 75, 2, p. 323-333 11 p.

Research output: Contribution to journalArticle

60 Citations (Scopus)

Cannabidiolic acid prevents vomiting in Suncus murinus and nausea-induced behaviour in rats by enhancing 5-HT(1A) receptor activation

Bolognini, D., Rock, EM., Cluny, NL., Cascio, MG., Limebeer, CL., Duncan, M., Stott, CG., Javid, FA., Parker, LA. & Pertwee, RG., Mar 2013, In : British Journal of Pharmacology. 168, 6, p. 1456-1470 15 p.

Research output: Contribution to journalArticle

Receptor, Serotonin, 5-HT1A
Nausea
Vomiting
Lithium Chloride
Shrews
77 Citations (Scopus)

Cannabidivarin-rich cannabis extracts are anticonvulsant in mouse and rat via a CB1 receptor-independent mechanism

Hill, T. D. M., Cascio, M-G., Romano, B., Duncan, M., Pertwee, R. G., Williams, C. M., Whalley, B. J. & Hill, A. J., Oct 2013, In : British Journal of Pharmacology. 170, 3, p. 679-692 14 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB1
Cannabis
Anticonvulsants
Seizures
Pharmaceutical Preparations
54 Citations (Scopus)

Cannabinoids and omega-3/6 endocannabinoids as cell death and anticancer modulators

Brown, I., Cascio, M. G., Rotondo, D., Pertwee, R. G., Heys, S. D. & Wahle, K. W. J., Jan 2013, In : Progress in Lipid Research. 52, 1, p. 80-109 30 p.

Research output: Contribution to journalArticle

Endocannabinoids
Cannabinoids
Cell death
Modulators
Cell Death
69 Citations (Scopus)

CB1 Receptor Allosteric Modulators Display Both Agonist and Signaling Pathway Specificity

Baillie, G. L., Horswill, J. G., Anavi-Goffer, S., Reggio, P. H., Bolognini, D., Abood, M. E., McAllister, S., Strange, P. G., Stephens, G. J., Pertwee, R. G. & Ross, R. A., Feb 2013, In : Molecular Pharmacology. 83, 2, p. 322-338 17 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Characterization of cannabinoid receptor ligands in tissues natively expressing cannabinoid CB2 receptors

Marini, P., Cascio, M. G., King, A., Pertwee, R. G. & Ross, R. A., Jun 2013, In : British Journal of Pharmacology. 169, 4, p. 887-899 13 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Cannabinoid Receptors
CHO Cells
Ligands
Spleen
23 Citations (Scopus)

Motor effects of the non-psychotropic phytocannabinoid cannabidiol that are mediated by 5-HT1A receptors

Espejo-Porras, F., Fernandez-Ruiz, J., Pertwee, R. G., Mechoulam, R. & Garcia, C., Dec 2013, In : Neuropharmacology. 75, p. 155-163 9 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

The cannabinoid TRPA1 agonist cannabichromene inhibits nitric oxide production in macrophages and ameliorates murine colitis

Romano, B., Borrelli, F., Fasolino, I., Capasso, R., Piscitelli, F., Cascio, M. G., Pertwee, R. G., Coppola, D., Vassallo, L., Orlando, P., Di Marzo, V. & Izzo, A. A., May 2013, In : British Journal of Pharmacology. 169, 1, p. 213-229 16 p.

Research output: Contribution to journalArticle

Ankyrins
Cannabinoid Receptors
Colitis
Cannabinoid Receptor CB1
Nitric Oxide
2012
30 Citations (Scopus)

AM630 behaves as a protean ligand at the human cannabinoid CB2 receptor

Bolognini, D., Cascio, M. G., Parolaro, D. & Pertwee, R. G., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2561-2574 14 p.

Research output: Contribution to journalArticle

Cannabinoid Receptor CB2
Ligands
Cannabinoids
CHO Cells
Cell Membrane
94 Citations (Scopus)

Cannabidiol, a non-psychotropic component of cannabis, attenuates vomiting and nausea-like behaviour via indirect agonism of 5-HT1A somatodendritic autoreceptors in the dorsal raphe nucleus

Rock, E. M., Bolognini, D., Limebeer, C. L., Cascio, M. G., Anavi-Goffer, S., Fletcher, P. J., Mechoulam, R., Pertwee, R. G. & Parker, L. A., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2620-2634 15 p.

Research output: Contribution to journalArticle

Cannabidiol
Autoreceptors
Cannabis
Nausea
Vomiting
21 Citations (Scopus)

Delta(8)-Tetrahydrocannabivarin prevents hepatic ischaemia/reperfusion injury by decreasing oxidative stress and inflammatory responses through cannabinoid CB2 receptors

Batkai, S., Mukhopadhyay, P., Horvath, B., Rajesh, M., Gao, R. Y., Mahadevan, A., Amere, M., Battista, N., Lichtman, A. H., Gauson, L. A., Maccarrone, M., Pertwee, R. G. & Pacher, P., Apr 2012, In : British Journal of Pharmacology. 165, 8, p. 2450-2461 12 p.

Research output: Contribution to journalArticle

13 Citations (Scopus)

Investigations on the 4-quinolone-3-carboxylic acid motif. 6. Synthesis and pharmacological evaluation of 7-substituted quinolone-3-carboxamide derivatives as high affinity ligands for cannabinoid receptors

Pasquini, S., De Rosa, M., Ligresti, A., Mugnaini, C., Brizzi, A., Caradonna, N. P., Cascio, M. G., Bolognini, D., Pertwee, R. G., Di Marzo, V. & Corelli, F., Dec 2012, In : European Journal of Medicinal Chemistry. 58, p. 30-43 14 p.

Research output: Contribution to journalArticle

23 Citations (Scopus)

Investigations on the 4-Quinolone-3-Carboxylic Acid Motif Part 5: Modulation of the Physicochemical Profile of a Set of Potent and Selective Cannabinoid-2 Receptor Ligands through a Bioisosteric Approach

Mugnaini, C., Nocerino, S., Pedani, V., Pasquini, S., Tafi, A., De Chiaro, M., Bellucci, L., Valoti, M., Guida, F., Luongo, L., Dragoni, S., Ligresti, A., Rosenberg, A., Bolognini, D., Cascio, M. G., Pertwee, R. G., Moaddel, R., Maione, S., Di Marzo, V. & Corelli, F., May 2012, In : ChemMedChem. 7, 5, p. 920-934 15 p.

Research output: Contribution to journalArticle

Cannabinoid Receptors
Triazoles
Cannabinoids
Amides
4-Quinolones

Manipulation of the endocannabinoid system to provide a protective benefit in the MPTP-mouse model

Mounsey, R. B., Mustafa, S., Strachan, L., Riedel, G., Ross, R., Pertwee, R. G. & Teismann, P., Aug 2012.

Research output: Contribution to conferencePoster

65 Citations (Scopus)

Modulation of L-α-lysophosphatidylinositol/GPR55 mitogen-activated protein kinase (MAPK) signaling by cannabinoids

Anavi-Goffer, S., Baillie, G., Irving, A., Gertsch, J., Greig, I. R., Pertwee, R. G. & Ross, R. A., 2 Jan 2012, In : The Journal of Biological Chemistry. 287, 1, p. 91-104 15 p.

Research output: Contribution to journalArticle

61 Citations (Scopus)

Sativex-like Combination of Phytocannabinoids is Neuroprotective in Malonate-Lesioned Rats, an Inflammatory Model of Huntington's Disease: Role of CB1 and CB2 Receptors

Valdeolivas, S., Satta, V., Pertwee, R. G., Fernandez-Ruiz, J. & Sagredo, O., 9 Feb 2012, In : ACS Chemical Neuroscience. 3, 5, p. 400-406 7 p.

Research output: Contribution to journalArticle

The endocannabinoid 2-AG provides neuroprotection in the MPTP model of Parkinson's disease

Mounsey, R. B., Mustafa, S., Ross, R., Pertwee, R. G. & Teismann, P., 2012.

Research output: Contribution to conferenceOther

2011

N-(ARYLALKYL)-1H-INDOLE-2-SULFONIC ACID AMIDE COMPOUNDS AND THEIR THERAPEUTIC USE AS CANNABINOID ALLOSTERIC MODULATORS

Greig, I. R., Ross, R. A., Trembleau, L. A. C., Pertwee, R. G. & Abdelrahman, M. H., 28 Feb 2011, IPC No. WO2012117216, Patent No. WO2012117216

Research output: Patent

Cannabinoid Receptors
Sulfonic Acids
Cannabinoids
Therapeutic Uses
Amides
24 Citations (Scopus)

Omega-3 N-acylethanolamines are endogenously synthesised from omega-3 fatty acids in different human prostate and breast cancer cell lines

Brown, I., Wahle, K. W., Cascio, M. G., Smoum, R., Mechoulam, R., Pertwee, R. G. & Heys, S. D., Dec 2011, In : Prostaglandins, Leukotrienes and Essential Fatty Acids. 85, 6, p. 305-310 6 p.

Research output: Contribution to journalArticle

Omega-3 Fatty Acids
Endocannabinoids
Prostatic Neoplasms
Cells
Breast Neoplasms
24 Citations (Scopus)

Structural and pharmacological analysis of O-2050, a putative neutral cannabinoid CB(1) receptor antagonist

Wiley, J. L., Breivogel, C. S., Mahadevan, A., Pertwee, R. G., Cascio, M. G., Bolognini, D., Huffman, J. W., Walentiny, D. M., Vann, R. E., Razdan, R. K. & Martin, B. R., 25 Jan 2011, In : European Journal of Pharmacology. 651, 1-3, p. 96-105 10 p.

Research output: Contribution to journalArticle

Cannabinoids
rimonabant
Pharmacology
Cannabinoid Receptor Agonists
Sulfonamides

The endocannabinoid 2-AG provides neuroprotection in the MPTP model of Parkinson's disease

Mounsey, R. B., Mustafa, S., Ross, R., Pertwee, R. G. & Teismann, P., 2011.

Research output: Contribution to conferencePoster

2010
24 Citations (Scopus)

Biochanin A, a naturally occurring inhibitor of fatty acid amide hydrolase

Thors, L., Burston, J. J., Alter, B. J., McKinney, M. K., Cravatt, B. F., Ross, R. A., Pertwee, R. G., Gereau, R. W., Wiley, J. L. & Fowler, C. J., Jun 2010, In : British Journal of Pharmacology. 160, 3, p. 549-560 12 p.

Research output: Contribution to journalArticle