Roger Pertwee

Professor

    • 26438 Citations
    1970 …2020

    Research output per year

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    Research Output

    1970

    Preliminary experiments on chemistry and pharmacology of cannabis

    Gill, E. W., Paton, W. D. M. & Pertwee, R. G., 1970, In : Nature. 228, 5267, p. 134

    Research output: Contribution to journalArticle

    150 Citations (Scopus)
    1972

    A metabolic interaction in vivo between cannabidiol and A1-tetrahydrocannabinol

    Pertwee, R. G. & Jones, G., 1972, In : British Journal of Pharmacology. 45, 2, p. 375

    Research output: Contribution to journalComment/debate

    66 Citations (Scopus)
    104 Citations (Scopus)

    The effect of cannabidiol on the level of delta-1-THC and its metabolites in mouse brain

    Pertwee, R. G., 1972, Cannabis and its derivatives: Pharmacology and Experimental Psychology. Paton, W. D. M. & Crown, J. (eds.). London, United Kingdom: Oxford University Press, p. 193-195 3 p.

    Research output: Chapter in Book/Report/Conference proceedingChapter

    The general pharmacology of cannabinoids

    Paton, W. D. M., Pertwee, R. G. & Temple, D., 1972, Cannabis and its derivatives: Pharmacology and Experimental Psychology. Paton, W. D. M. & Crown, J. (eds.). London, United Kingdom: Oxford University Press, p. 50-75

    Research output: Chapter in Book/Report/Conference proceedingChapter

    171 Citations (Scopus)
    1973
    12 Citations (Scopus)

    Clinical aspects of cannabis action

    Paton, W. D. M., Pertwee, R. G. & Tylden, E., 1973, Marijuana: Chemistry, Pharmacology, Metabolism and Clinical Effects. New York, USA: Academic Press, p. 335-365

    Research output: Chapter in Book/Report/Conference proceedingChapter

    The actions of cannabis in man

    Paton, W. D. M. & Pertwee, R. G., 1973, Marijuana: Chemistry, Pharmacology, Metabolism and Clinical Effects. Mechoulam, R. (ed.). New York,USA: Academic Press, p. 287-333

    Research output: Chapter in Book/Report/Conference proceedingChapter

    The pharmacology of cannabis in animals

    Paton, W. D. M. & Pertwee, R. G., 1973, Marijuana: Chemistry, Pharmacology, Metabolism and Clinical Effects. Mechoulam, R. (ed.). New York, USA: Academic Press, p. 191-285

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1974

    Brain levels and relative potency of 1,2-dimethylheptyl analog of delta1-tetrahydrocannabinol in mice

    Lawrence, D. K., Pertwee, R. G., Gill, E. W. & Piper, J. M., 1974, In : Biochemical Pharmacology. 23, 21, p. 3017-3027 11 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Relative pharmacological potency in mice of optical isomers of delta1-tetrahydrocannabinol

    Jones, G., Pertwee, R. G., Gill, E. W., Paton, W. D. M., Nilsson, I. M., Widman, M. & Agurell, S., 15 Jan 1974, In : Biochemical Pharmacology. 23, 2, p. 439-446 8 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)
    1977

    Effects of delta-9-tetrahydrocannabinol and cannabidiol on a MG2+-atpase of synaptic vesicles prepared from rat cerebral-cortex

    Gilbert, J., Pertwee, R. G. & Wyllie, M. G., 1977, In : British Journal of Pharmacology. 59, 4, p. 599-601 3 p.

    Research output: Contribution to journalArticle

    8 Citations (Scopus)

    Effects of delta-9-tetrahydrocannabinol on rates of oxygen-consumption of mice

    Pertwee, R. G. & Tavendale, R., 1977, In : British Journal of Pharmacology. 60, 4, p. 559-568 10 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)
    1979
    6 Citations (Scopus)
    1980

    Effects of delta-9-tetrahydrocannabinol on autonomic and behavioural thermoregulation in mice

    Pertwee, R. G. & Tavendale, R., 1980, Thermoregulatory Mechanisms and their Therapeutic Implications: 4th Symposium on the Pharmacology of Thermoregulation. Cox, B., Lomax, P., Milton, A. S. & Schönbaum, E. (eds.). Basel, Switzerland: Karger, p. 57-61

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Thermoregulatory effects of N6-2'-0-dibutyryl adenosine-3',5'-monophosphate in the restrained mouse

    Dascombe, M. J., Milton, AS., Nyemiteiaddo, I. & Pertwee, R. G., 1980, In : British Journal of Pharmacology. 70, 3, p. 453-459 7 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)

    Therapeutic agents affecting body temperature

    Pertwee, R. G., 22 Nov 1982, Pyretics and Antipyretics: Handbook of experimental pharmacology ; vol 60 . Milton, A. S. & van Arman, C. G. (eds.). Berlin, Germany: Springer-Verlag, Vol. 60. p. 377-435 (Handbook of Experimental Pharmacology).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1983

    Cannabis

    Pertwee, R. G., 1983, Psychopharmacology 1: Part 1 Preclinical Psychopharmacology. Grahame-Smith, D. G. & Cowen, P. J. (eds.). Amsterdam: Excerpta Medica, Vol. 1. p. 377-397

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Cannabis

    Pertwee, R. G., 1983, Psychopharmacology 2: Part 1 Preclinical Psychopharmacology. Grahame-Smith, D. G. & Cowen, P. J. (eds.). Amsterdam: Elsevier, p. 364-391

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Prostaglandin hyperthermia in mice: effects of ambient temperature

    Milton, A. S., Pertwee, R. G. & Todd, D. A., 1983, Environment, Drugs and Thermoregulation: 5th International Symposium on the Pharmacology of Thermoregulation. Lomax, P. & Schönbaum, E. (eds.). Basel, Switzerland: Karger, p. 150-152

    Research output: Chapter in Book/Report/Conference proceedingChapter

    The effects of intrahypothalamic injections of delta-9-tetrahydrocannabinol, dopamine and prostaglandin E2 on behavioural thermoregulation in mice

    Pertwee, R. G., Moochhala, S., Nyemitei-Addo, I. & Todd, D. A., 1983, Environment, Drugs and Thermoregulation: 5th International Symposium on the Pharmacology of Thermoregulation. Lomax, P. & Schonbaum, E. (eds.). Basel, Switzerland: Karger, p. 82-85

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1985

    Effects of cannabinoids on thermoregulation: a brief review

    Pertwee, R. G., 1985, Marihuana '84: proceedings of the Oxford Symposium on Cannabis . Harvey, D. J., Paton, S. W. & Nahas, G. G. (eds.). Oxford, United Kingdom: IRL Press, p. 263-277

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1986

    An interaction between chlorpromazine and delta-9-tetrahydrocannabinol

    Hedley, D. & Pertwee, R. G., 1986, Homeostasis and Thermal Stress: experimental and therapeutic advances : 6th International symposium on the pharmacology of thermoregulation : Papers . Cooper, K., Lomax, P., Schönbaum, E. & Veale, W. L. (eds.). Basel, Switzerland: Karger, p. 163-165

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Effects of subanesthetic doses of inert-gases on behavioral thermoregulation in mice

    Pertwee, R. G., MacDonald, A. G. & Marshall, N. R., Nov 1986, In : Journal of Applied Physiology. 61, 5, p. 1623-1633 11 p.

    Research output: Contribution to journalArticle

    5 Citations (Scopus)

    The effect of subanaesthetic partial pressures of nitrous oxide and nitrogen on behavioural thermoregulation in mice

    Pertwee, R. G., Marshall, N. R. & MacDonald, A. G., 1986, Homeostasis and Thermal Stress: experimental and therapeutic advances: 6th International symposium on the pharmacology of thermoregulation : Papers . Cooper, K., Lomax, P., Schönbaum, E. & Veale, W. L. (eds.). Basel, Switzerland: Karger, p. 19-21

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1987

    Enhancement of the hypothermic response of mice to delta-9-tetrahydrocannabinol by subhypothermic doses of chloropromazine and phentolamine

    Gray, G. A., Hedley, D. & Pertwee, R. G., Feb 1987, In : Neuropharmacology. 26, 2-3, p. 229-235 7 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)
    1988

    Delta-9-tetrahydrocannabinol-induced catalepsy in mice is enhanced by pretreatment with flurazepam or chlorodiazepoxide

    Pertwee, R. G. & Greentree, S. G., May 1988, In : Neuropharmacology. 27, 5, p. 485-491 7 p.

    Research output: Contribution to journalArticle

    33 Citations (Scopus)
    58 Citations (Scopus)

    Synergistic interactions between delta-9-THC and flurazepam : further studies

    Pertwee, R. G. & Greentree, S. G., 1988, Marijuana: An International Research Report. Chesher, G., Consroe, P. & Musty, R. (eds.). Canberra, Australia: Australian Government Publishing Service, p. 365-370 (Monograph series (National Campaign Against Drug Abuse (Australia)); no. 7).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    6 Citations (Scopus)
    1989

    Behavioral thermoregulation in mice subjected to high-pressure

    MacDonald, A. G., Pertwee, R. G. & Marshall, N. R., Jan 1989, In : Journal of Applied Physiology. 66, 1, p. 238-244 7 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Does chlorpromazine enhance the hypothermic response to delta-9-tetrahydrocannabinol by blocking peripheral alpha-adrenoceptors?

    Pertwee, R. G. & Gentleman, S. M., 1989, Thermoregulation: Research and Clinical Applications. Lomax, P. & Schönbaum, E. (eds.). Basel, Switzerland: Karger, p. 197-199

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1990

    Behavioural thermoregulation in mice: effects of low-doses of general-anesthetics of different potency

    Pertwee, R. G., Marshall, N. R. & MacDonald, A. G., Sep 1990, In : Experimental Physiology. 75, 5, p. 629-637 9 p.

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Hydrostatic pressure modifies behavioural thermoregulation in mice

    MacDonald, A. G., Pertwee, R. G. & Marshall, N. R., 1990, High Pressure Neurological Syndrome - 20 years Later: 1st Meeting of the International Group on High Pressure Biology. Rostain, J-C., Martinez, E. & Lemair, C. (eds.). Marseille, France: ARAS-SNHP, p. 261-273

    Research output: Chapter in Book/Report/Conference proceedingChapter

    The central neuropharmacology of psychotropic cannabinoids

    Pertwee, R. G., 1 Apr 1990, International Encyclopedia of Pharmacology and Therapeutics, Section 130: Psychotropic Drugs of Abuse. Balfour, D. J. K. (ed.). New York, USA: Pergamon Press, p. 355-429

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1991

    An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol

    Pertwee, R. G., Browne, S. E., Stretton, C. D. & Ross, T. M., Nov 1991, In : Pharmacology, Biochemistry & Behavior. 40, 3, p. 581-585 5 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)
    65 Citations (Scopus)
    1992

    Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas-deferens and the myenteric plexus preparation of guinea-pig small-intestine

    Pertwee, R. G., Stevenson, L. A., Elrick, D. B., Mechoulam, R. & Corbett, A. D., Apr 1992, In : British Journal of Pharmacology. 105, 4, p. 980-984 5 p.

    Research output: Contribution to journalArticle

    134 Citations (Scopus)

    In vivo interactions between psychotropic cannabinoids and other drugs involving central and peripheral neurochemical mediators

    Pertwee, R. G., 14 Aug 1992, Marijuana/Cannabinoids: Neurobiology and Neurophysiology. Murphy, L. L. & Bartke, A. (eds.). Boca Raton, FL, USA: CRC Press, p. 165-218 (Physiology of Substance Abuse).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    Isolation and structure of a brain constituent that binds to the cannabinoid receptor

    Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. & Mechoulam, R., 18 Dec 1992, In : Science. 258, 5090, p. 1946-1949 4 p.

    Research output: Contribution to journalArticle

    4141 Citations (Scopus)

    Tolerance to and dependence on psychotropic cannabinoids

    Pertwee, R. G., Jan 1992, The Biological Bases of Drug Tolerance and Dependence. Pratt, J. A. (ed.). London, United Kingdom: Academic Press, p. 231-263 (Neuroscience perspectives).

    Research output: Chapter in Book/Report/Conference proceedingChapter

    1993

    ¿9-tetrahydrocannabinol and anandamide enhance the ability of muscimol to induce catalepsy in the globus pallidus of rats

    Wickens, A. P. & Pertwee, R. G., 30 Nov 1993, In : European Journal of Pharmacology. 250, 1, p. 205-208 4 p.

    Research output: Contribution to journalComment/debate

    49 Citations (Scopus)
    1994

    (R)-Methanandamide : a chiral novel anandamide possessing higher potency and metabolic stability

    Abadji, V., Lin, S. Y., Taha, G., Griffin, G., Stevenson, L. A., Pertwee, R. G. & Makriyannis, A., 10 Jun 1994, In : Journal of Medicinal Chemistry. 37, 12, p. 1889-1893 5 p.

    Research output: Contribution to journalComment/debate

    297 Citations (Scopus)

    Cannabinoid receptors: pharmacology, second messenger systems and endogenous ligands

    Martin, B. R., Childers, S., Howlett, A., Mechoulam, R. & Pertwee, R. G., 1994, Problems of Drug Dependence, 1993: Proceeding of the 55th Annual Scientific Meeting of the College on Problems of Drug Dependence, Inc.. Harris, L. (ed.). Bethesda, MD, USA: National Institutes of Health (NIH), Vol. 1. p. 55-60 (National Institute on Drug Abuse Research Monograph Series; no. 140).

    Research output: Chapter in Book/Report/Conference proceedingChapter