Roger Pertwee

Professor

    • 27140 Citations
    1970 …2020

    Research output per year

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    1970

    Preliminary experiments on chemistry and pharmacology of cannabis

    Gill, E. W., Paton, W. D. M. & Pertwee, R. G., 1970, In : Nature. 228, 5267, p. 134

    Research output: Contribution to journalArticle

    153 Citations (Scopus)
    1972
    104 Citations (Scopus)
    172 Citations (Scopus)
    1974

    Brain levels and relative potency of 1,2-dimethylheptyl analog of delta1-tetrahydrocannabinol in mice

    Lawrence, D. K., Pertwee, R. G., Gill, E. W. & Piper, J. M., 1974, In : Biochemical Pharmacology. 23, 21, p. 3017-3027 11 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)

    Relative pharmacological potency in mice of optical isomers of delta1-tetrahydrocannabinol

    Jones, G., Pertwee, R. G., Gill, E. W., Paton, W. D. M., Nilsson, I. M., Widman, M. & Agurell, S., 15 Jan 1974, In : Biochemical Pharmacology. 23, 2, p. 439-446 8 p.

    Research output: Contribution to journalArticle

    27 Citations (Scopus)
    1977

    Effects of delta-9-tetrahydrocannabinol and cannabidiol on a MG2+-atpase of synaptic vesicles prepared from rat cerebral-cortex

    Gilbert, J., Pertwee, R. G. & Wyllie, M. G., 1977, In : British Journal of Pharmacology. 59, 4, p. 599-601 3 p.

    Research output: Contribution to journalArticle

    9 Citations (Scopus)

    Effects of delta-9-tetrahydrocannabinol on rates of oxygen-consumption of mice

    Pertwee, R. G. & Tavendale, R., 1977, In : British Journal of Pharmacology. 60, 4, p. 559-568 10 p.

    Research output: Contribution to journalArticle

    21 Citations (Scopus)
    1979
    6 Citations (Scopus)
    1980

    Thermoregulatory effects of N6-2'-0-dibutyryl adenosine-3',5'-monophosphate in the restrained mouse

    Dascombe, M. J., Milton, AS., Nyemiteiaddo, I. & Pertwee, R. G., 1980, In : British Journal of Pharmacology. 70, 3, p. 453-459 7 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)
    1986

    Effects of subanesthetic doses of inert-gases on behavioral thermoregulation in mice

    Pertwee, R. G., MacDonald, A. G. & Marshall, N. R., Nov 1986, In : Journal of Applied Physiology. 61, 5, p. 1623-1633 11 p.

    Research output: Contribution to journalArticle

    5 Citations (Scopus)
    1987

    Enhancement of the hypothermic response of mice to delta-9-tetrahydrocannabinol by subhypothermic doses of chloropromazine and phentolamine

    Gray, G. A., Hedley, D. & Pertwee, R. G., Feb 1987, In : Neuropharmacology. 26, 2-3, p. 229-235 7 p.

    Research output: Contribution to journalArticle

    4 Citations (Scopus)
    1988

    Delta-9-tetrahydrocannabinol-induced catalepsy in mice is enhanced by pretreatment with flurazepam or chlorodiazepoxide

    Pertwee, R. G. & Greentree, S. G., May 1988, In : Neuropharmacology. 27, 5, p. 485-491 7 p.

    Research output: Contribution to journalArticle

    34 Citations (Scopus)
    59 Citations (Scopus)
    6 Citations (Scopus)
    1989

    Behavioral thermoregulation in mice subjected to high-pressure

    MacDonald, A. G., Pertwee, R. G. & Marshall, N. R., Jan 1989, In : Journal of Applied Physiology. 66, 1, p. 238-244 7 p.

    Research output: Contribution to journalArticle

    2 Citations (Scopus)
    1990

    Behavioural thermoregulation in mice: effects of low-doses of general-anesthetics of different potency

    Pertwee, R. G., Marshall, N. R. & MacDonald, A. G., Sep 1990, In : Experimental Physiology. 75, 5, p. 629-637 9 p.

    Research output: Contribution to journalArticle

    9 Citations (Scopus)
    1991

    An investigation of the involvement of GABA in certain pharmacological effects of delta-9-tetrahydrocannabinol

    Pertwee, R. G., Browne, S. E., Stretton, C. D. & Ross, T. M., Nov 1991, In : Pharmacology, Biochemistry & Behavior. 40, 3, p. 581-585 5 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)
    65 Citations (Scopus)
    1992

    Inhibitory effects of certain enantiomeric cannabinoids in the mouse vas-deferens and the myenteric plexus preparation of guinea-pig small-intestine

    Pertwee, R. G., Stevenson, L. A., Elrick, D. B., Mechoulam, R. & Corbett, A. D., Apr 1992, In : British Journal of Pharmacology. 105, 4, p. 980-984 5 p.

    Research output: Contribution to journalArticle

    135 Citations (Scopus)

    Isolation and structure of a brain constituent that binds to the cannabinoid receptor

    Devane, W. A., Hanus, L., Breuer, A., Pertwee, R. G., Stevenson, L. A., Griffin, G., Gibson, D., Mandelbaum, A., Etinger, A. & Mechoulam, R., 18 Dec 1992, In : Science. 258, 5090, p. 1946-1949 4 p.

    Research output: Contribution to journalArticle

    4201 Citations (Scopus)
    1994

    Effects of two endogenous fatty acid ethanolamides on mouse vasa deferentia

    Pertwee, R. G., Griffin, G., Hanus, L. & Mechoulam, R., 1 Jul 1994, In : European Journal of Pharmacology. 259, 2, p. 115-120 6 p.

    Research output: Contribution to journalArticle

    49 Citations (Scopus)
    1995

    AM630, a competitive cannabinoid receptor antagonist

    Pertwee, R. G., Griffin, G., Fernando, S., Li, X., Hill, A. & Makriyannis, A., 5 May 1995, In : Life Sciences. 56, 23-24, p. 1949-1955 7 p.

    Research output: Contribution to journalArticle

    120 Citations (Scopus)

    A preliminary investigation of the mechanisms underlying cannabinoid tolerance in the mouse vas deferens

    Pertwee, R. G. & Griffin, G., 5 Jan 1995, In : European Journal of Pharmacology. 272, 1, p. 67-72 6 p.

    Research output: Contribution to journalArticle

    19 Citations (Scopus)

    Effect of phenylmethylsulfonyl fluoride on the potency of anandamide as an inhibitor of electrically-evoked contractions in 2 isolated tissue preparations

    Pertwee, R. G., Fernando, S. R., Griffin, G., Abadji, V. & Makriyannis, A., 5 Jan 1995, In : European Journal of Pharmacology. 272, 1, p. 73-78 6 p.

    Research output: Contribution to journalArticle

    78 Citations (Scopus)

    IDENTIFICATION OF AN ENDOGENOUS 2-MONOGLYCERIDE, PRESENT IN CANINE GUT, THAT BINDS TO CANNABINOID RECEPTORS

    MECHOULAM, R., BENSHABAT, S., HANUS, L., LIGUMSKY, M., KAMINSKI, N. E., SCHATZ, A. R., GOPHER, A., ALMOG, S., COMPTON, D. R., Pertwee, R. G., GRIFFIN, G., BAYEWITCH, M., BARG, J., VOGEL, Z. & Martin, B. R., 29 Jun 1995, In : Biochemical Pharmacology. 50, 1, p. 83-90 8 p.

    Research output: Contribution to journalArticle

    2086 Citations (Scopus)

    Pharmacological characterization of three novel cannabinoid receptor agonists in the mouse isolated vas deferens

    Pertwee, R. G., GRIFFIN, G., LAINTON, J. A. H. & HUFFMAN, J. W., 25 Sep 1995, In : European Journal of Pharmacology. 284, 3, p. 241-247 7 p.

    Research output: Contribution to journalArticle

    59 Citations (Scopus)

    The design, synthesis and testing of deoxy-CBD : further evidence for a region of steric interference at the cannabinoid receptor

    Reggio, P. H., Bramblett, R. D., Yuknavich, H., Seltzman, H. H., Fleming, D. N., Fernando, S. R., Stevenson, L. A. & Pertwee, R. G., 5 May 1995, In : Life Sciences. 56, 23-24, p. 2025-2032 8 p.

    Research output: Contribution to journalArticle

    13 Citations (Scopus)
    1996

    Agonist-antagonist characterization of 6'-cyanohex-2'-yne-Delta(8)-tetrahydrocannabinol in two isolated tissue preparations

    Pertwee, R. G., Fernando, S. R., Griffin, G., Ryan, W., Razdan, R. K., Compton, D. R. & Billy R., M., 14 Nov 1996, In : European Journal of Pharmacology. 315, 2, p. 195-201 7 p.

    Research output: Contribution to journalArticle

    40 Citations (Scopus)

    Evidence for the presence of cannabinoid CB1 receptors in mouse urinary bladder

    Pertwee, R. G. & Fernando, S. R., Aug 1996, In : British Journal of Pharmacology. 118, 8, p. 2053-2058 6 p.

    Research output: Contribution to journalArticle

    117 Citations (Scopus)

    Further evidence for the presence of cannabinoid CB1, receptors in mouse vas deferens

    Pertwee, R. G., JoeAdigwe, G. & Hawksworth, G. M., 25 Jan 1996, In : European Journal of Pharmacology. 296, 2, p. 169-172 4 p.

    Research output: Contribution to journalArticle

    32 Citations (Scopus)

    Further evidence for the presence of cannabinoid CB1 receptors in guinea-pig small intestine

    Pertwee, R. G., Fernando, S. R., Nash, J. E. & Coutts, A. A., Aug 1996, In : British Journal of Pharmacology. 118, 8, p. 2199-2205 7 p.

    Research output: Contribution to journalArticle

    156 Citations (Scopus)

    Effects of cannabinoid receptor ligands on electrophysiological properties of myenteric neurones of the guinea-pig ileum

    LopezRedondo, F., Lees, G. M. & Pertwee, R. G., Sep 1997, In : British Journal of Pharmacology. 122, 2, p. 330-334 5 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals

    Griffin, G., Fernando, S. R., Ross, R. A., McKay, G., Ashford, M. L. J., Shire, D., Huffman, J. W., Yu, S., Lainton, J. A. H. & Pertwee, R. G., 19 Nov 1997, In : European Journal of Pharmacology. 339, 1, p. 53-61 9 p.

    Research output: Contribution to journalArticle

    152 Citations (Scopus)

    Evidence that methyl arachidonyl fluorophosphonate is an irreversible cannabinoid receptor antagonist

    Fernando, S. R. & Pertwee, R. G., Aug 1997, In : British Journal of Pharmacology. 121, 8, p. 1716-1720 5 p.

    Research output: Contribution to journalArticle

    47 Citations (Scopus)

    Importance of the C-1 substituent in classical cannabinoids to CB2 receptor selectivity: Synthesis and characterization of a series of O,2-propano-Delta(8)-tetrahydrocannabinol analogs

    Reggio, P. H., Wang, T., Brown, A. E., Fleming, D. N., Seltzman, H. H., Griffin, G., Pertwee, R. G., Compton, D. R., Abood, M. E. & Martin, R., 26 Sep 1997, In : Journal of Medicinal Chemistry. 40, 20, p. 3312-3318 7 p.

    Research output: Contribution to journalArticle

    20 Citations (Scopus)

    Inhibition by cannabinoid receptor agonists of acetylcholine release from the guinea-pig myenteric plexus

    Coutts, A. A. & Pertwee, R. G., Aug 1997, In : British Journal of Pharmacology. 121, 8, p. 1557-1566 10 p.

    Research output: Contribution to journalArticle

    132 Citations (Scopus)

    Synthesis and pharmacological comparison of dimethylheptyl and pentyl analogs of anandamide

    Seltzman, H. H., Fleming, D. N., Thomas, B. F., Gilliam, A. F., McCallion, D. S., Pertwee, R. G., Compton, D. R. & Martin, B. R., 24 Oct 1997, In : Journal of Medicinal Chemistry. 40, 22, p. 3626-3634 9 p.

    Research output: Contribution to journalArticle

    58 Citations (Scopus)

    The perceived effects of smoked cannabis on patients with multiple sclerosis

    Consroe, P., Musty, R., Rein, J., Tillery, W. & Pertwee, R. G., 1997, In : European Journal of Neurology. 38, 1, p. 44-48 5 p.

    Research output: Contribution to journalArticle

    252 Citations (Scopus)
    1998

    Comparison of cannabinoid binding sites in guinea-pig forebrain and small intestine

    Ross, R. A., Brockie, H. C., Fernando, S. R., Saha, B., Razdan, R. K. & Pertwee, R. G., Nov 1998, In : British Journal of Pharmacology. 125, 6, p. 1345-1351 7 p.

    Research output: Contribution to journalArticle

    41 Citations (Scopus)
    50 Citations (Scopus)

    Interactions between synthetic vanilloids and the endogenous cannabinoid system

    Di Marzo, V., Bisogno, T., Melck, D., Ross, R. A., Brockie, H., Stevenson, L. A., Pertwee, R. G. & De Petrocellis, L., 9 Oct 1998, In : FEBS Letters. 436, 3, p. 449-454 6 p.

    Research output: Contribution to journalArticle

    133 Citations (Scopus)

    The bioactive conformation of aminoalkylindoles at the cannabinoid CB1 and CB2 receptors: Insights gained from (E)- and (Z)-naphthylidene indenes

    Reggio, P. H., Basu-Dutt, S., Barnett-Norris, J., Castro, M. T., Hurst, D. P., Seltzman, H. H., Roche, M. J., Gilliam, A. F., Thomas, B. F., Stevenson, L. A., Pertwee, R. G. & Abood, M. E., 1998, In : Journal of Medicinal Chemistry. 41, p. 5177-5187 11 p.

    Research output: Contribution to journalArticle

    60 Citations (Scopus)
    1999

    Agonist inverse agonist characterization at CB1 and CB2 cannabinoid receptors of L759633, L759656 and AM630

    Ross, R. A., Brockie, H. C., Stevenson, L. A., Murphy, V. L., Templeton, F., Makriyannis, A. & Pertwee, R. G., Feb 1999, In : British Journal of Pharmacology. 126, 3, p. 665-672 8 p.

    Research output: Contribution to journalArticle

    325 Citations (Scopus)